Expression of ACCS in cancer - Summary - The Human Protein Atlas

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ACCS

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	ACCS
Gene description	1-aminocyclopropane-1-carboxylate synthase homolog (Arabidopsis)(non-functional)
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Mixed
HPA (normal tissue):	Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Ubiquitous cytoplasmic expression, most abundant in lymphoid tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 2 antibodies. HPA018873 , HPA021654
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PROGNOSTIC SUMMARY
Prognostic marker in pancreatic cancer (favourable).
Pancreatic cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA018873	HPA021654

GENE INFORMATION
Gene name	ACCS (HGNC Symbol)
Synonyms	ACS, PHACS
Description	1-aminocyclopropane-1-carboxylate synthase homolog (Arabidopsis)(non-functional) (HGNC Symbol)
Entrez gene summary
Chromosome	11
Cytoband	p11.2
Chromosome location (bp)	44065925 - 44084222
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000110455 (version 83.38)
Entrez gene	84680
UniProt	Q96QU6 (UniProt - Evidence at protein level)
neXtProt	NX_Q96QU6
Antibodypedia	ACCS antibodies

PROTEIN BROWSER

ACCS-001	ACCS-005	ACCS-006

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ACCS-001 ENSP00000263776 ENST00000263776	Q96QU6 [Direct mapping] 1-aminocyclopropane-1-carboxylate synthase-like protein 1 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Show all	GO:0005515 [protein binding] GO:0009058 [biosynthetic process] GO:0030170 [pyridoxal phosphate binding] GO:0042803 [protein homodimerization activity] Show all	501 aa 57.3 kDa	No	0
ACCS-005 ENSP00000434156 ENST00000524990	E9PRT9 [Direct mapping] 1-aminocyclopropane-1-carboxylate synthase-like protein 1 Show all	Predicted intracellular proteins Show all		139 aa 16 kDa	No	0
ACCS-006 ENSP00000435919 ENST00000533404	E9PS61 [Direct mapping] 1-aminocyclopropane-1-carboxylate synthase-like protein 1 Show all	Predicted intracellular proteins Show all		77 aa 8.6 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.