Expression of SCGB2A2 in cancer - Summary

GENERAL INFORMATION
Gene name	SCGB2A2
Gene description	Secretoglobin, family 2A, member 2
Protein class	Cancer-related genes Predicted secreted proteins
Predicted localization	Secreted
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enriched (breast cancer)
HPA (cell line):	Cell line enriched (SK-BR-3)
HPA (normal tissue):	Tissue enriched (breast)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in ductal cells with additional plasma positivity in lactating breast.

ANTIBODY IHC RELIABILITY
Data reliability description	No internal RNA expression data available for correlation. Secreted protein, tissue location of RNA and protein might differ and correlation is complex.
Reliability score	Supported based on 1 antibody. CAB026270
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PROGNOSTIC SUMMARY
Prognostic marker in endometrial cancer (favourable).
Endometrial cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enriched (breast cancer)

PROTEIN EXPRESSION

STAINING SUMMARY

CAB026270

GENE INFORMATION
Gene name	SCGB2A2 (HGNC Symbol)
Synonyms	MGB1, MGC71974, UGB2
Description	Secretoglobin, family 2A, member 2 (HGNC Symbol)
Entrez gene summary
Chromosome	11
Cytoband	q12.3
Chromosome location (bp)	62270155 - 62273156
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000110484 (version 83.38)
Entrez gene	4250
UniProt	Q13296 (UniProt - Evidence at protein level)
neXtProt	NX_Q13296
Antibodypedia	SCGB2A2 antibodies

PROTEIN BROWSER

SCGB2A2-001	SCGB2A2-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SCGB2A2-001 ENSP00000227918 ENST00000227918	Q13296 [Direct mapping] Mammaglobin-A Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Cancer-related genes Candidate cancer biomarkers Show all	GO:0003674 [molecular_function] GO:0005515 [protein binding] GO:0005575 [cellular_component] GO:0008150 [biological_process] Show all	93 aa 10.5 kDa	Yes	0
SCGB2A2-002 ENSP00000431997 ENST00000525380	Q6NX70 [Direct mapping] Mammaglobin-A; SCGB2A2 protein Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all		120 aa 13.3 kDa	Yes	0