Expression of CARS in cancer - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	CARS
Gene description	Cysteinyl-tRNA synthetase
Protein class	Cancer-related genes Disease related genes Enzymes Potential drug targets Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Mixed
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in most tissues. Most abundant in exocrine pancreas and neuronal cells.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Supported based on 6 antibodies. HPA002383 , HPA002384 , CAB075734 , CAB075735 , CAB075736 , CAB075737
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable) and liver cancer (unfavourable).
Renal cancer p<0.001 Liver cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

STAINING SUMMARY

HPA002383	HPA002384	CAB075734	CAB075735	CAB075736	CAB075737

GENE INFORMATION
Gene name	CARS (HGNC Symbol)
Synonyms	CARS1
Description	Cysteinyl-tRNA synthetase (HGNC Symbol)
Entrez gene summary	This gene encodes a class 1 aminoacyl-tRNA synthetase, cysteinyl-tRNA synthetase. Each of the twenty aminoacyl-tRNA synthetases catalyzes the aminoacylation of a specific tRNA or tRNA isoaccepting family with the cognate amino acid. This gene is one of several located near the imprinted gene domain on chromosome 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian and breast cancers. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Aug 2010]
Chromosome	11
Cytoband	p15.4
Chromosome location (bp)	3000922 - 3057613
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000110619 (version 83.38)
Entrez gene	833
UniProt	P49589 (UniProt - Evidence at protein level)
neXtProt	NX_P49589
Antibodypedia	CARS antibodies

PROTEIN BROWSER

CARS-001	CARS-002	CARS-004	CARS-016

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CARS-001 ENSP00000380300 ENST00000397111	P49589 [Direct mapping] Cysteine--tRNA ligase, cytoplasmic A0A024RCG3 [Target identity:100%; Query identity:100%] Cysteinyl-tRNA synthetase, isoform CRA_a Show all	Enzymes ENZYME proteins Ligase Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000049 [tRNA binding] GO:0000166 [nucleotide binding] GO:0004812 [aminoacyl-tRNA ligase activity] GO:0004817 [cysteine-tRNA ligase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006418 [tRNA aminoacylation for protein translation] GO:0006423 [cysteinyl-tRNA aminoacylation] GO:0010467 [gene expression] GO:0042803 [protein homodimerization activity] GO:0046872 [metal ion binding] Show all	748 aa 85.5 kDa	No	0
CARS-002 ENSP00000278224 ENST00000278224	P49589 [Direct mapping] Cysteine--tRNA ligase, cytoplasmic Show all	Enzymes ENZYME proteins Ligase Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000049 [tRNA binding] GO:0000166 [nucleotide binding] GO:0004812 [aminoacyl-tRNA ligase activity] GO:0004817 [cysteine-tRNA ligase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006418 [tRNA aminoacylation for protein translation] GO:0006423 [cysteinyl-tRNA aminoacylation] GO:0010467 [gene expression] GO:0042803 [protein homodimerization activity] GO:0046872 [metal ion binding] Show all	726 aa 82.8 kDa	No	0
CARS-004 ENSP00000369897 ENST00000380525	P49589 [Direct mapping] Cysteine--tRNA ligase, cytoplasmic Show all	Enzymes ENZYME proteins Ligase Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000049 [tRNA binding] GO:0000166 [nucleotide binding] GO:0004812 [aminoacyl-tRNA ligase activity] GO:0004817 [cysteine-tRNA ligase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006418 [tRNA aminoacylation for protein translation] GO:0006423 [cysteinyl-tRNA aminoacylation] GO:0010467 [gene expression] GO:0042803 [protein homodimerization activity] GO:0046872 [metal ion binding] Show all	831 aa 94.6 kDa	No	0
CARS-016 ENSP00000432619 ENST00000529772	B4DKY1 [Direct mapping] Cysteine--tRNA ligase, cytoplasmic; cDNA FLJ59563, highly similar to Cysteinyl-tRNA synthetase (EC 6.1.1.16) Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0000166 [nucleotide binding] GO:0004812 [aminoacyl-tRNA ligase activity] GO:0004817 [cysteine-tRNA ligase activity] GO:0005524 [ATP binding] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006418 [tRNA aminoacylation for protein translation] GO:0006423 [cysteinyl-tRNA aminoacylation] Show all	739 aa 84.3 kDa	No	0