Expression of CD81 in cancer - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	CD81
Gene description	CD81 molecule
Protein class	CD markers Disease related genes Plasma proteins Potential drug targets Predicted membrane proteins Transporters
Predicted localization	Membrane
Number of transcripts	12
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Mixed
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic and membranous expression in mainly in tissue stroma with additional high levels in seminiferous ducts and lymphoid germinal center cells.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Antibody staining in cells/structures not annotated, view images.
Reliability score	Supported based on 2 antibodies. HPA007234 , CAB002507
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PROGNOSTIC SUMMARY
Prognostic marker in glioma (unfavourable), pancreatic cancer (favourable) and colorectal cancer (unfavourable).
Glioma p<0.001 Pancreatic cancer p<0.001 Colorectal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

STAINING SUMMARY

HPA007234	CAB002507

GENE INFORMATION
Gene name	CD81 (HGNC Symbol)
Synonyms	TAPA-1, TAPA1, TSPAN28
Description	CD81 molecule (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that is known to complex with integrins. This protein appears to promote muscle cell fusion and support myotube maintenance. Also it may be involved in signal transduction. This gene is localized in the tumor-suppressor gene region and thus it is a candidate gene for malignancies. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]
Chromosome	11
Cytoband	p15.5
Chromosome location (bp)	2376177 - 2397419
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000110651 (version 83.38)
Entrez gene	975
UniProt	P60033 (UniProt - Evidence at protein level)
neXtProt	NX_P60033
Antibodypedia	CD81 antibodies

PROTEIN BROWSER

CD81-001	CD81-002	CD81-003	CD81-004	CD81-005	CD81-006	CD81-007	CD81-012	CD81-013	CD81-014	CD81-015	CD81-017

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CD81-001 ENSP00000263645 ENST00000263645	P60033 [Direct mapping] CD81 antigen A0A024RCB7 [Target identity:100%; Query identity:100%] Tetraspanin Show all	CD markers Transporters Accessory Factors Involved in Transport Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Plasma proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000187 [activation of MAPK activity] GO:0001772 [immunological synapse] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0005925 [focal adhesion] GO:0007166 [cell surface receptor signaling pathway] GO:0008104 [protein localization] GO:0008283 [cell proliferation] GO:0008284 [positive regulation of cell proliferation] GO:0009611 [response to wounding] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016324 [apical plasma membrane] GO:0023026 [MHC class II protein complex binding] GO:0030890 [positive regulation of B cell proliferation] GO:0031647 [regulation of protein stability] GO:0031982 [vesicle] GO:0040008 [regulation of growth] GO:0042127 [regulation of cell proliferation] GO:0043128 [positive regulation of 1-phosphatidylinositol 4-kinase activity] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0046718 [viral entry into host cell] GO:0046813 [receptor-mediated virion attachment to host cell] GO:0050731 [positive regulation of peptidyl-tyrosine phosphorylation] GO:0050776 [regulation of immune response] GO:0061462 [protein localization to lysosome] GO:0070062 [extracellular exosome] GO:1904352 [positive regulation of protein catabolic process in the vacuole] GO:1990459 [transferrin receptor binding] GO:2000145 [regulation of cell motility] Show all	236 aa 25.8 kDa	No	4
CD81-002 ENSP00000433178 ENST00000475945	E9PM31 [Direct mapping] CD81 antigen Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	93 aa 10.1 kDa	No	1
CD81-003 ENSP00000437242 ENST00000492627	E9PJK1 [Direct mapping] Tetraspanin Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	165 aa 18 kDa	No	2
CD81-004 ENSP00000432497 ENST00000493525	E9PQV4 [Direct mapping] CD81 antigen Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	99 aa 10.7 kDa	No	3
CD81-005 ENSP00000370424 ENST00000381036	A6NMH8 [Direct mapping] Tetraspanin Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	274 aa 29.8 kDa	Yes	4
CD81-006 ENSP00000432249 ENST00000492252	E9PRJ8 [Direct mapping] Tetraspanin Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	209 aa 22.5 kDa	No	4
CD81-007 ENSP00000432033 ENST00000481687	E9PIF1 [Direct mapping] Tetraspanin Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	242 aa 25.9 kDa	No	3
CD81-012 ENSP00000432723 ENST00000530648	E9PPF5 [Direct mapping] CD81 antigen Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	52 aa 5.7 kDa	No	1
CD81-013 ENSP00000435633 ENST00000533417	H0YEE2 [Direct mapping] Tetraspanin Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	148 aa 16 kDa	No	3
CD81-014 ENSP00000433767 ENST00000527343	H0YDJ9 [Direct mapping] Tetraspanin Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	225 aa 24.4 kDa	No	4
CD81-015 ENSP00000433904 ENST00000464784	H0YDL9 [Direct mapping] Tetraspanin Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	221 aa 23.7 kDa	No	4
CD81-017 ENSP00000431780 ENST00000526072	E9PJK1 [Direct mapping] Tetraspanin Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	165 aa 18 kDa	No	2