Expression of NDUFS8 in cancer - Summary - The Human Protein Atlas

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NDUFS8

TISSUE

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CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	NDUFS8
Gene description	NADH dehydrogenase (ubiquinone) Fe-S protein 8, 23kDa (NADH-coenzyme Q reductase)
Protein class	Disease related genes Enzymes Potential drug targets Predicted intracellular proteins Predicted secreted proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	6
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in several tissues, including skeletal and heart muscle.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Approved based on 1 antibody. HPA018524
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable).
Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA018524

GENE INFORMATION
Gene name	NDUFS8 (HGNC Symbol)
Synonyms	CI-23k, TYKY
Description	NADH dehydrogenase (ubiquinone) Fe-S protein 8, 23kDa (NADH-coenzyme Q reductase) (HGNC Symbol)
Entrez gene summary	This gene encodes a subunit of mitochondrial NADH:ubiquinone oxidoreductase, or Complex I, a multimeric enzyme of the respiratory chain responsible for NADH oxidation, ubiquinone reduction, and the ejection of protons from mitochondria. The encoded protein is involved in the binding of two of the six to eight iron-sulfur clusters of Complex I and, as such, is required in the electron transfer process. Mutations in this gene have been associated with Leigh syndrome. [provided by RefSeq, Mar 2010]
Chromosome	11
Cytoband	q13.2
Chromosome location (bp)	68030617 - 68036644
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000110717 (version 83.38)
Entrez gene	4728
UniProt	O00217 (UniProt - Evidence at protein level)
neXtProt	NX_O00217
Antibodypedia	NDUFS8 antibodies

PROTEIN BROWSER

NDUFS8-001	NDUFS8-004	NDUFS8-011	NDUFS8-013	NDUFS8-014	NDUFS8-015

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
NDUFS8-001 ENSP00000315774 ENST00000313468	O00217 [Direct mapping] NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial Show all	Enzymes ENZYME proteins Oxidoreductases Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003954 [NADH dehydrogenase activity] GO:0005739 [mitochondrion] GO:0005747 [mitochondrial respiratory chain complex I] GO:0005759 [mitochondrial matrix] GO:0006120 [mitochondrial electron transport, NADH to ubiquinone] GO:0006979 [response to oxidative stress] GO:0008137 [NADH dehydrogenase (ubiquinone) activity] GO:0016020 [membrane] GO:0016651 [oxidoreductase activity, acting on NAD(P)H] GO:0022904 [respiratory electron transport chain] GO:0032981 [mitochondrial respiratory chain complex I assembly] GO:0044237 [cellular metabolic process] GO:0044281 [small molecule metabolic process] GO:0046872 [metal ion binding] GO:0051539 [4 iron, 4 sulfur cluster binding] GO:0055114 [oxidation-reduction process] Show all	210 aa 23.7 kDa	Yes	0
NDUFS8-004 ENSP00000432848 ENST00000528492	Q08E91 [Direct mapping] NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial; NDUFS8 protein Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0046872 [metal ion binding] GO:0051539 [4 iron, 4 sulfur cluster binding] Show all	64 aa 7.4 kDa	No	0
NDUFS8-011 ENSP00000403972 ENST00000453471	F8W9K7 [Direct mapping] NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		124 aa 13.9 kDa	Yes	0
NDUFS8-013 ENSP00000433521 ENST00000525419	E9PKH6 [Direct mapping] NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0016020 [membrane] GO:0016651 [oxidoreductase activity, acting on NAD(P)H] GO:0051539 [4 iron, 4 sulfur cluster binding] GO:0055114 [oxidation-reduction process] Show all	138 aa 15.9 kDa	No	0
NDUFS8-014 ENSP00000432968 ENST00000525628	E9PN51 [Direct mapping] NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial Show all	MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		110 aa 12.4 kDa	Yes	0
NDUFS8-015 ENSP00000436287 ENST00000526339	E9PPW7 [Direct mapping] NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0016020 [membrane] GO:0016651 [oxidoreductase activity, acting on NAD(P)H] GO:0051539 [4 iron, 4 sulfur cluster binding] GO:0055114 [oxidation-reduction process] Show all	184 aa 20.7 kDa	Yes	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.