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GTF2H1

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GENERAL INFORMATION

Gene name

 GTF2H1

Gene description

 General transcription factor IIH, polypeptide 1, 62kDa

Protein class

 Cancer-related genes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 7
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Localized to the nucleoplasm.

RNA cell category

 Expressed in all

Protein evidence

 Evidence at protein level

Main location

 Localized to the Nucleoplasm (validated)

Mouse

 Localized to the Nucleoplasm in mouse cells.

DATA RELIABILITY

Reliability score

 Validated based on 2 antibodies.
CAB004637 , HPA046660
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ASSAYS
RNA expression
Human cells
Mouse cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Localized to the nucleoplasm.

Main location

 Nucleoplasm (validated)

 

 

 
Toggle channels
Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
CAB004637 A-431 Nucleoplasm
CAB004637 U-2 OS Nucleoplasm
CAB004637 U-251 MG Nucleoplasm
HPA046660 A-431 Nucleoplasm
HPA046660 PC-3 Nucleoplasm
HPA046660 U-2 OS Nucleoplasm

MOUSE CELLS

Main location

 Nucleoplasm

Mouse gene

 ENSMUSG00000006599 (version 83)

 

 

 
Toggle channels
Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location
HPA046660 NIH 3T3 Nucleoplasm

GENE INFORMATION

Gene name

 GTF2H1 (HGNC Symbol)

Synonyms

 BTF2, P62, TFIIH

Description

 General transcription factor IIH, polypeptide 1, 62kDa (HGNC Symbol)

Entrez gene summary

Chromosome

 11

Cytoband

 p15.1

Chromosome location (bp)

 18322295 - 18367044

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000110768 (version 83.38)

Entrez gene

 2965

UniProt

 P32780 (UniProt - Evidence at protein level)

neXtProt

 NX_P32780

Antibodypedia

 GTF2H1 antibodies

PROTEIN BROWSER
GTF2H1-001
GTF2H1-002
GTF2H1-003
GTF2H1-006
GTF2H1-010
GTF2H1-011
GTF2H1-014

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
GTF2H1-001
ENSP00000265963
ENST00000265963
P32780 [Direct mapping]
General transcription factor IIH subunit 1
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000079 [regulation of cyclin-dependent protein serine/threonine kinase activity]
GO:0000439 [core TFIIH complex]
GO:0003682 [chromatin binding]
GO:0004672 [protein kinase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005675 [holo TFIIH complex]
GO:0006281 [DNA repair]
GO:0006283 [transcription-coupled nucleotide-excision repair]
GO:0006289 [nucleotide-excision repair]
GO:0006360 [transcription from RNA polymerase I promoter]
GO:0006361 [transcription initiation from RNA polymerase I promoter]
GO:0006362 [transcription elongation from RNA polymerase I promoter]
GO:0006363 [termination of RNA polymerase I transcription]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0006368 [transcription elongation from RNA polymerase II promoter]
GO:0006370 [7-methylguanosine mRNA capping]
GO:0006468 [protein phosphorylation]
GO:0008094 [DNA-dependent ATPase activity]
GO:0008353 [RNA polymerase II carboxy-terminal domain kinase activity]
GO:0010467 [gene expression]
GO:0016032 [viral process]
GO:0033683 [nucleotide-excision repair, DNA incision]
GO:0040029 [regulation of gene expression, epigenetic]
GO:0045814 [negative regulation of gene expression, epigenetic]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0050434 [positive regulation of viral transcription]
GO:0070911 [global genome nucleotide-excision repair]
Show all
 548 aa
62 kDa 		No 0
GTF2H1-002
ENSP00000393638
ENST00000453096
P32780 [Direct mapping]
General transcription factor IIH subunit 1
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000079 [regulation of cyclin-dependent protein serine/threonine kinase activity]
GO:0000439 [core TFIIH complex]
GO:0004672 [protein kinase activity]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005675 [holo TFIIH complex]
GO:0006281 [DNA repair]
GO:0006283 [transcription-coupled nucleotide-excision repair]
GO:0006289 [nucleotide-excision repair]
GO:0006360 [transcription from RNA polymerase I promoter]
GO:0006361 [transcription initiation from RNA polymerase I promoter]
GO:0006362 [transcription elongation from RNA polymerase I promoter]
GO:0006363 [termination of RNA polymerase I transcription]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0006368 [transcription elongation from RNA polymerase II promoter]
GO:0006370 [7-methylguanosine mRNA capping]
GO:0006468 [protein phosphorylation]
GO:0008094 [DNA-dependent ATPase activity]
GO:0008353 [RNA polymerase II carboxy-terminal domain kinase activity]
GO:0010467 [gene expression]
GO:0016032 [viral process]
GO:0033683 [nucleotide-excision repair, DNA incision]
GO:0040029 [regulation of gene expression, epigenetic]
GO:0045814 [negative regulation of gene expression, epigenetic]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0050434 [positive regulation of viral transcription]
GO:0070911 [global genome nucleotide-excision repair]
Show all
 548 aa
62 kDa 		No 0
GTF2H1-003
ENSP00000435375
ENST00000534641
P32780 [Direct mapping]
General transcription factor IIH subunit 1
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000079 [regulation of cyclin-dependent protein serine/threonine kinase activity]
GO:0000439 [core TFIIH complex]
GO:0004672 [protein kinase activity]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005675 [holo TFIIH complex]
GO:0006281 [DNA repair]
GO:0006283 [transcription-coupled nucleotide-excision repair]
GO:0006289 [nucleotide-excision repair]
GO:0006360 [transcription from RNA polymerase I promoter]
GO:0006361 [transcription initiation from RNA polymerase I promoter]
GO:0006362 [transcription elongation from RNA polymerase I promoter]
GO:0006363 [termination of RNA polymerase I transcription]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0006368 [transcription elongation from RNA polymerase II promoter]
GO:0006370 [7-methylguanosine mRNA capping]
GO:0006468 [protein phosphorylation]
GO:0008094 [DNA-dependent ATPase activity]
GO:0008353 [RNA polymerase II carboxy-terminal domain kinase activity]
GO:0010467 [gene expression]
GO:0016032 [viral process]
GO:0033683 [nucleotide-excision repair, DNA incision]
GO:0040029 [regulation of gene expression, epigenetic]
GO:0045814 [negative regulation of gene expression, epigenetic]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0050434 [positive regulation of viral transcription]
GO:0070911 [global genome nucleotide-excision repair]
Show all
 432 aa
48.7 kDa 		No 0
GTF2H1-006
ENSP00000431481
ENST00000525831
E9PL58 [Direct mapping]
General transcription factor IIH subunit 1
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000439 [core TFIIH complex]
GO:0006289 [nucleotide-excision repair]
GO:0006351 [transcription, DNA-templated]
Show all
 95 aa
10.7 kDa 		No 0
GTF2H1-010
ENSP00000433133
ENST00000530496
E9PM51 [Direct mapping]
General transcription factor IIH subunit 1
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000439 [core TFIIH complex]
GO:0006289 [nucleotide-excision repair]
GO:0006351 [transcription, DNA-templated]
Show all
 236 aa
26.7 kDa 		No 0
GTF2H1-011
ENSP00000439774
ENST00000526630
F5H0Y9 [Direct mapping]
General transcription factor IIH subunit 1
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000439 [core TFIIH complex]
GO:0006289 [nucleotide-excision repair]
GO:0006351 [transcription, DNA-templated]
Show all
 138 aa
15.8 kDa 		No 0
GTF2H1-014
ENSP00000436575
ENST00000524753
E9PI26 [Direct mapping]
General transcription factor IIH subunit 1
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000439 [core TFIIH complex]
GO:0006289 [nucleotide-excision repair]
GO:0006351 [transcription, DNA-templated]
Show all
 181 aa
20.4 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.