Expression of POU2AF1 in cancer - Summary - The Human Protein Atlas

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POU2AF1

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	POU2AF1
Gene description	POU class 2 associating factor 1
Protein class	Cancer-related genes Disease related genes Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Mixed
HPA (cell line):	Cell line enhanced (Daudi, Karpas-707, U-266/70, U-698)
HPA (normal tissue):	Tissue enhanced (lymph node, tonsil)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Nuclear and cytoplasmic expression in subsets of lymphoid cells in several tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Presumed off target binding observed and disregarded. Antibody staining in cells/structures not annotated, view images.
Reliability score	Approved based on 1 antibody. CAB011193
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PROGNOSTIC SUMMARY
Prognostic marker in cervical cancer (favourable), breast cancer (favourable) and head and neck cancer (favourable).
Cervical cancer p<0.001 Breast cancer p<0.001 Head and neck cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Mixed

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

CAB011193

GENE INFORMATION
Gene name	POU2AF1 (HGNC Symbol)
Synonyms	OBF1
Description	POU class 2 associating factor 1 (HGNC Symbol)
Entrez gene summary
Chromosome	11
Cytoband	q23.1
Chromosome location (bp)	111352252 - 111455630
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000110777 (version 83.38)
Entrez gene	5450
UniProt	Q16633 (UniProt - Evidence at protein level)
neXtProt	NX_Q16633
Antibodypedia	POU2AF1 antibodies

PROTEIN BROWSER

POU2AF1-001	POU2AF1-007

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
POU2AF1-001 ENSP00000376786 ENST00000393067	Q16633 [Direct mapping] POU domain class 2-associating factor 1 Show all	Predicted intracellular proteins Plasma proteins Cancer-related genes Mutated cancer genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Show all	GO:0003677 [DNA binding] GO:0003712 [transcription cofactor activity] GO:0003713 [transcription coactivator activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0006355 [regulation of transcription, DNA-templated] GO:0006366 [transcription from RNA polymerase II promoter] GO:0006959 [humoral immune response] Show all	256 aa 27.4 kDa	No	0
POU2AF1-007 ENSP00000433527 ENST00000531398	E9PKH4 [Direct mapping] POU domain class 2-associating factor 1 Show all	Predicted intracellular proteins Cancer-related genes Mutated cancer genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Show all		127 aa 13.7 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.