Expression of PPFIBP1 in cancer - Summary - The Human Protein Atlas

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PPFIBP1

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	PPFIBP1
Gene description	PTPRF interacting protein, binding protein 1 (liprin beta 1)
Protein class	Cancer-related genes Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	13
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Mixed
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

General cytoplasmic expression.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Uncertain based on 1 antibody. HPA001924
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable), pancreatic cancer (unfavourable), lung cancer (unfavourable) and endometrial cancer (unfavourable).
Renal cancer p<0.001 Pancreatic cancer p<0.001 Lung cancer p<0.001 Endometrial cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA001924

GENE INFORMATION
Gene name	PPFIBP1 (HGNC Symbol)
Synonyms	hSGT2, hSgt2p, L2, SGT2
Description	PTPRF interacting protein, binding protein 1 (liprin beta 1) (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a member of the LAR protein-tyrosine phosphatase-interacting protein (liprin) family. Liprins interact with members of LAR family of transmembrane protein tyrosine phosphatases, which are known to be important for axon guidance and mammary gland development. It has been proposed that liprins are multivalent proteins that form complex structures and act as scaffolds for the recruitment and anchoring of LAR family of tyrosine phosphatases. This protein was found to interact with S100A4, a calcium-binding protein related to tumor invasiveness and metastasis. In vitro experiment demonstrated that the interaction inhibited the phosphorylation of this protein by protein kinase C and protein kinase CK2. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
Chromosome	12
Cytoband
Chromosome location (bp)	27523431 - 27695564
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000110841 (version 83.38)
Entrez gene	8496
UniProt	Q86W92 (UniProt - Evidence at protein level)
neXtProt	NX_Q86W92
Antibodypedia	PPFIBP1 antibodies

PROTEIN BROWSER

PPFIBP1-001	PPFIBP1-002	PPFIBP1-003	PPFIBP1-005	PPFIBP1-006	PPFIBP1-007	PPFIBP1-008	PPFIBP1-009	PPFIBP1-010	PPFIBP1-012	PPFIBP1-015	PPFIBP1-016	PPFIBP1-018

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PPFIBP1-001 ENSP00000228425 ENST00000228425	Q86W92 [Direct mapping] Liprin-beta-1 Show all	Predicted intracellular proteins Plasma proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005925 [focal adhesion] GO:0007155 [cell adhesion] Show all	1005 aa 113.2 kDa	No	0
PPFIBP1-002 ENSP00000444304 ENST00000540114	F5GZP6 [Direct mapping] Liprin-beta-1 Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	744 aa 84.1 kDa	No	0
PPFIBP1-003 ENSP00000445425 ENST00000537927	Q86W92 [Direct mapping] Liprin-beta-1 A0A024RB02 [Target identity:100%; Query identity:100%] PTPRF interacting protein, binding protein 1 (Liprin beta 1), isoform CRA_a Show all	Predicted intracellular proteins Plasma proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005925 [focal adhesion] GO:0007155 [cell adhesion] Show all	858 aa 97 kDa	No	0
PPFIBP1-005 ENSP00000438036 ENST00000545334	F5H0E0 [Direct mapping] Liprin-beta-1 Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all		109 aa 12 kDa	No	0
PPFIBP1-006 ENSP00000444046 ENST00000535047	Q86W92 [Direct mapping] Liprin-beta-1 Show all	Predicted intracellular proteins Plasma proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0005886 [plasma membrane] GO:0005925 [focal adhesion] GO:0007155 [cell adhesion] Show all	170 aa 19 kDa	No	0
PPFIBP1-007 ENSP00000314724 ENST00000318304	Q86W92 [Direct mapping] Liprin-beta-1 Show all	Predicted intracellular proteins Plasma proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005925 [focal adhesion] GO:0007155 [cell adhesion] Show all	1011 aa 114 kDa	No	0
PPFIBP1-008 ENSP00000443442 ENST00000542629	Q86W92 [Direct mapping] Liprin-beta-1 Show all	Predicted intracellular proteins Plasma proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005925 [focal adhesion] GO:0007155 [cell adhesion] Show all	980 aa 110.3 kDa	No	0
PPFIBP1-009 ENSP00000442462 ENST00000538433	F5H7K5 [Direct mapping] Liprin-beta-1 Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all		18 aa 2.1 kDa	No	0
PPFIBP1-010 ENSP00000437438 ENST00000535575	F5H6Q7 [Direct mapping] Liprin-beta-1 Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all		86 aa 9.4 kDa	No	0
PPFIBP1-012 ENSP00000438174 ENST00000539326	H0YFE4 [Direct mapping] Liprin-beta-1 Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	242 aa 27.2 kDa	No	0
PPFIBP1-015 ENSP00000445132 ENST00000542187	F5H495 [Direct mapping] Liprin-beta-1 Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all		152 aa 16.9 kDa	No	0
PPFIBP1-016 ENSP00000443324 ENST00000537261	H0YGH8 [Direct mapping] Liprin-beta-1 Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all		205 aa 22.4 kDa	No	0
PPFIBP1-018 ENSP00000479763 ENST00000619325	A0A087WVX8 [Direct mapping] Liprin-beta-1 Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all		86 aa 9.5 kDa	No	0

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