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CD69

GENERAL INFORMATION

Gene name

 CD69

Gene description

 CD69 molecule

Protein class

 CD markers
Predicted membrane proteins

Predicted localization

 Membrane

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (bone marrow, lymph node)
GTEx:Tissue enhanced (spleen)
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in subsets of immune cells.

DATA RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data.

Reliability score

 Supported based on 2 antibodies.
HPA050525 , CAB002503
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Appendix

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (bone marrow, lymph node)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (spleen)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 CD69 (HGNC Symbol)

Synonyms

 CLEC2C

Description

 CD69 molecule (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the calcium dependent lectin superfamily of type II transmembrane receptors. Expression of the encoded protein is induced upon activation of T lymphocytes, and may play a role in proliferation. Furthermore, the protein may act to transmit signals in natural killer cells and platelets. [provided by RefSeq, Aug 2011]

Chromosome

 12

Cytoband

 p13.31

Chromosome location (bp)

 9752486 - 9760901

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000110848 (version 83.38)

Entrez gene

 969

UniProt

 Q07108 (UniProt - Evidence at protein level)

neXtProt

 NX_Q07108

Antibodypedia

 CD69 antibodies

PROTEIN BROWSER
CD69-001
CD69-003

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CD69-001
ENSP00000228434
ENST00000228434
Q07108 [Direct mapping]
Early activation antigen CD69
Q53ZX0 [Target identity:100%; Query identity:100%]
CD69 antigen; CD69 antigen (P60, early T-cell activation antigen), isoform CRA_a; cDNA FLJ75888, highly similar to Homo sapiens CD69 antigen (p60, early T-cell activation antigen) (CD69), mRNA
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CD markers
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0004888 [transmembrane signaling receptor activity]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005887 [integral component of plasma membrane]
GO:0007165 [signal transduction]
GO:0009897 [external side of plasma membrane]
GO:0030246 [carbohydrate binding]
GO:0035690 [cellular response to drug]
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 199 aa
22.6 kDa 		No 1
CD69-003
ENSP00000442597
ENST00000536709
B4E009 [Direct mapping]
Early activation antigen CD69; cDNA FLJ55409, highly similar to Early activation antigen CD69
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Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0016021 [integral component of membrane]
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 164 aa
18.5 kDa 		No 1

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.