Tissue expression of COQ5 - Summary - The Human Protein Atlas

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COQ5

TISSUE

CELL

PATHOLOGY

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	COQ5
Gene description	Coenzyme Q5, methyltransferase
Protein class	Enzymes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	6
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Expressed in all
GTEx:	Expressed in all
FANTOM5:	Expressed in all

Protein evidence

Evidence at protein level

Protein expression

Cytoplasmic expression in several different tissue types.

DATA RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 1 antibody. HPA049487
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

Skin

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
GTEx dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Expressed in all

GENE INFORMATION
Gene name	COQ5 (HGNC Symbol)
Synonyms	MGC4767
Description	Coenzyme Q5, methyltransferase (HGNC Symbol)
Entrez gene summary
Chromosome	12
Cytoband	q24.31
Chromosome location (bp)	120503274 - 120534434
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000110871 (version 83.38)
Entrez gene	84274
UniProt	Q5HYK3 (UniProt - Evidence at protein level)
neXtProt	NX_Q5HYK3
Antibodypedia	COQ5 antibodies

PROTEIN BROWSER

COQ5-001	COQ5-002	COQ5-004	COQ5-005	COQ5-006	COQ5-009

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
COQ5-001 ENSP00000288532 ENST00000288532	Q5HYK3 [Direct mapping] 2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial Show all	Enzymes ENZYME proteins Transferases SCAMPI predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005739 [mitochondrion] GO:0005743 [mitochondrial inner membrane] GO:0006744 [ubiquinone biosynthetic process] GO:0008168 [methyltransferase activity] GO:0008757 [S-adenosylmethionine-dependent methyltransferase activity] GO:0032259 [methylation] GO:0044281 [small molecule metabolic process] Show all	327 aa 37.1 kDa	No	0
COQ5-002 ENSP00000401798 ENST00000445328	B4DP72 [Direct mapping] 2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial; cDNA FLJ55122, highly similar to Ubiquinone biosynthesis methyltransferaseCOQ5, mitochondrial (EC 2.1.1.-) Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005739 [mitochondrion] GO:0008168 [methyltransferase activity] GO:0008757 [S-adenosylmethionine-dependent methyltransferase activity] GO:0032259 [methylation] Show all	253 aa 28.5 kDa	No	0
COQ5-004 ENSP00000449874 ENST00000547943	F8VVW7 [Direct mapping] 2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005739 [mitochondrion] GO:0008168 [methyltransferase activity] GO:0008757 [S-adenosylmethionine-dependent methyltransferase activity] GO:0032259 [methylation] Show all	176 aa 19.9 kDa	No	0
COQ5-005 ENSP00000450001 ENST00000551769	F8VP53 [Direct mapping] 2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial Show all	SCAMPI predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005739 [mitochondrion] GO:0008168 [methyltransferase activity] GO:0008757 [S-adenosylmethionine-dependent methyltransferase activity] GO:0032259 [methylation] Show all	130 aa 14.9 kDa	No	0
COQ5-006 ENSP00000449933 ENST00000547736	F8VVD5 [Direct mapping] 2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005739 [mitochondrion] GO:0008168 [methyltransferase activity] GO:0008757 [S-adenosylmethionine-dependent methyltransferase activity] GO:0032259 [methylation] Show all	91 aa 9.9 kDa	No	0
COQ5-009 ENSP00000449863 ENST00000552443	F8VVX6 [Direct mapping] 2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial Show all	SCAMPI predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005739 [mitochondrion] GO:0008168 [methyltransferase activity] GO:0008757 [S-adenosylmethionine-dependent methyltransferase activity] GO:0032259 [methylation] Show all	213 aa 24.5 kDa	No	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.