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SELPLG

GENERAL INFORMATION

Gene name

 SELPLG

Gene description

 Selectin P ligand

Protein class

 Candidate cardiovascular disease genes
CD markers
Plasma proteins
Predicted membrane proteins

Predicted localization

 Membrane

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Cell line enhanced (HDLM-2, HMC-1, Karpas-707, RPMI-8226, U-266/70, U-266/84)
HPA (normal tissue):Mixed

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in a subset of lymphoid cells.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Antibody staining in cells/structures not annotated, view images.

Reliability score

 Supported based on 1 antibody.
CAB002431
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PROGNOSTIC SUMMARY
Prognostic marker in cervical cancer (favourable), thyroid cancer (favourable), melanoma (favourable), renal cancer (unfavourable) and head and neck cancer (favourable).
Cervical cancer p<0.001
Thyroid cancer p<0.001
Melanoma p<0.001
Renal cancer p<0.001
Head and neck cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Lymphoma

STAINING SUMMARY
CAB002431

GENE INFORMATION

Gene name

 SELPLG (HGNC Symbol)

Synonyms

 CD162, PSGL-1

Description

 Selectin P ligand (HGNC Symbol)

Entrez gene summary

 This gene encodes a glycoprotein that functions as a high affinity counter-receptor for the cell adhesion molecules P-, E- and L- selectin expressed on myeloid cells and stimulated T lymphocytes. As such, this protein plays a critical role in leukocyte trafficking during inflammation by tethering of leukocytes to activated platelets or endothelia expressing selectins. This protein requires two post-translational modifications, tyrosine sulfation and the addition of the sialyl Lewis x tetrasaccharide (sLex) to its O-linked glycans, for its high-affinity binding activity. Aberrant expression of this gene and polymorphisms in this gene are associated with defects in the innate and adaptive immune response. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Apr 2011]

Chromosome

 12

Cytoband

 q24.11

Chromosome location (bp)

 108622277 - 108633959

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000110876 (version 83.38)

Entrez gene

 6404

UniProt

 Q14242 (UniProt - Evidence at protein level)

neXtProt

 NX_Q14242

Antibodypedia

 SELPLG antibodies

PROTEIN BROWSER
SELPLG-001
SELPLG-002
SELPLG-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SELPLG-001
ENSP00000447752
ENST00000550948
Q14242 [Direct mapping]
P-selectin glycoprotein ligand 1
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CD markers
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Candidate cardiovascular disease genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001618 [virus receptor activity]
GO:0001931 [uropod]
GO:0005102 [receptor binding]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0007155 [cell adhesion]
GO:0007596 [blood coagulation]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0046718 [viral entry into host cell]
GO:0050900 [leukocyte migration]
GO:0050902 [leukocyte adhesive activation]
GO:0071354 [cellular response to interleukin-6]
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 412 aa
43.2 kDa 		Yes 1
SELPLG-002
ENSP00000228463
ENST00000228463
Q14242 [Direct mapping]
P-selectin glycoprotein ligand 1
Show all
CD markers
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Candidate cardiovascular disease genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001618 [virus receptor activity]
GO:0001931 [uropod]
GO:0005102 [receptor binding]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0007155 [cell adhesion]
GO:0007596 [blood coagulation]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0046718 [viral entry into host cell]
GO:0050900 [leukocyte migration]
GO:0050901 [leukocyte tethering or rolling]
GO:0050902 [leukocyte adhesive activation]
GO:0071354 [cellular response to interleukin-6]
Show all
 428 aa
44.6 kDa 		Yes 1
SELPLG-201
ENSP00000373614
ENST00000388962
A0A0C4DFY0 [Direct mapping]
P-selectin glycoprotein ligand 1
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0016021 [integral component of membrane]
Show all
 402 aa
42.1 kDa 		Yes 1

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.