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ASIC1

GENERAL INFORMATION

Gene name

 ASIC1

Gene description

 Acid sensing (proton gated) ion channel 1

Protein class

 FDA approved drug targets
Predicted membrane proteins

Predicted localization

 Membrane

Number of transcripts

 5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Tissue enhanced (glioma)
HPA (cell line):Cell line enhanced (SH-SY5Y)
HPA (normal tissue):Tissue enriched (cerebral cortex)

Protein evidence

 Evidence at protein level

ANTIBODY IHC RELIABILITY

Reliability score

 Pending cancer tissue analysis.

PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Tissue enhanced (glioma)

PROTEIN EXPRESSION

Pending cancer tissue analysis

STAINING SUMMARY

 

GENE INFORMATION

Gene name

 ASIC1 (HGNC Symbol)

Synonyms

 ACCN2, BNaC2, hBNaC2

Description

 Acid sensing (proton gated) ion channel 1 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the acid-sensing ion channel (ASIC) family of proteins, which are part of the degenerin/epithelial sodium channel (DEG/ENaC) superfamily. Members of the ASIC family are sensitive to amiloride and function in neurotransmission. The encoded proteins function in learning, pain transduction, touch sensation, and development of memory and fear. Alternatively spliced transcript variants have been described. [provided by RefSeq, Feb 2012]

Chromosome

 12

Cytoband

 q13.12

Chromosome location (bp)

 50057548 - 50083611

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000110881 (version 83.38)

Entrez gene

 41

UniProt

 P78348 (UniProt - Evidence at protein level)

neXtProt

 NX_P78348

Antibodypedia

 ASIC1 antibodies

PROTEIN BROWSER
ASIC1-001
ASIC1-002
ASIC1-007
ASIC1-008
ASIC1-009

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ASIC1-001
ENSP00000228468
ENST00000228468
P78348 [Direct mapping]
Acid-sensing ion channel 1
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   # TM segments-based
   2TM proteins predicted by MDM
FDA approved drug targets
   Small molecule drugs
Show all
GO:0005216 [ion channel activity]
GO:0005261 [cation channel activity]
GO:0005272 [sodium channel activity]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006810 [transport]
GO:0006812 [cation transport]
GO:0006814 [sodium ion transport]
GO:0007165 [signal transduction]
GO:0007613 [memory]
GO:0008306 [associative learning]
GO:0009268 [response to pH]
GO:0009986 [cell surface]
GO:0010447 [response to acidic pH]
GO:0015280 [ligand-gated sodium channel activity]
GO:0016020 [membrane]
GO:0022839 [ion gated channel activity]
GO:0034220 [ion transmembrane transport]
GO:0035725 [sodium ion transmembrane transport]
GO:0042391 [regulation of membrane potential]
GO:0044736 [acid-sensing ion channel activity]
GO:0046929 [negative regulation of neurotransmitter secretion]
GO:0050915 [sensory perception of sour taste]
GO:0055085 [transmembrane transport]
GO:0070207 [protein homotrimerization]
GO:0070588 [calcium ion transmembrane transport]
GO:0071467 [cellular response to pH]
Show all
 574 aa
64.8 kDa 		No 2
ASIC1-002
ENSP00000400228
ENST00000447966
P78348 [Direct mapping]
Acid-sensing ion channel 1
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   # TM segments-based
   2TM proteins predicted by MDM
FDA approved drug targets
   Small molecule drugs
Show all
GO:0005272 [sodium channel activity]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006810 [transport]
GO:0006814 [sodium ion transport]
GO:0007165 [signal transduction]
GO:0009268 [response to pH]
GO:0015280 [ligand-gated sodium channel activity]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0034220 [ion transmembrane transport]
GO:0035725 [sodium ion transmembrane transport]
GO:0044736 [acid-sensing ion channel activity]
GO:0050915 [sensory perception of sour taste]
GO:0055085 [transmembrane transport]
GO:0070207 [protein homotrimerization]
GO:0071467 [cellular response to pH]
Show all
 528 aa
59.9 kDa 		No 2
ASIC1-007
ENSP00000402896
ENST00000453327
H7C1W9 [Direct mapping]
Acid-sensing ion channel 1
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Show all
GO:0005272 [sodium channel activity]
GO:0006814 [sodium ion transport]
GO:0015280 [ligand-gated sodium channel activity]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0035725 [sodium ion transmembrane transport]
Show all
 396 aa
44.6 kDa 		No 1
ASIC1-008
ENSP00000446863
ENST00000552633
H0YHD6 [Direct mapping]
Acid-sensing ion channel 1
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Show all
GO:0005272 [sodium channel activity]
GO:0006814 [sodium ion transport]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0035725 [sodium ion transmembrane transport]
Show all
 127 aa
14 kDa 		No 1
ASIC1-009
ENSP00000450247
ENST00000552438
P78348 [Direct mapping]
Acid-sensing ion channel 1
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   # TM segments-based
   2TM proteins predicted by MDM
FDA approved drug targets
   Small molecule drugs
Show all
GO:0005272 [sodium channel activity]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006810 [transport]
GO:0006814 [sodium ion transport]
GO:0007165 [signal transduction]
GO:0009268 [response to pH]
GO:0015280 [ligand-gated sodium channel activity]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0034220 [ion transmembrane transport]
GO:0035725 [sodium ion transmembrane transport]
GO:0044736 [acid-sensing ion channel activity]
GO:0050915 [sensory perception of sour taste]
GO:0055085 [transmembrane transport]
GO:0070207 [protein homotrimerization]
GO:0071467 [cellular response to pH]
Show all
 562 aa
62.7 kDa 		No 2

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.