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SLC11A2

GENERAL INFORMATION

Gene name

 SLC11A2

Gene description

 Solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2

Protein class

 Disease related genes
Potential drug targets
Predicted intracellular proteins
Predicted membrane proteins
Transporters

Predicted localization

 Intracellular,Membrane

Number of transcripts

 15
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic and membranous expression at variable levels in several different cell types.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data.

Reliability score

 Uncertain based on 2 antibodies.
HPA032139 , HPA032140
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PROGNOSTIC SUMMARY
Prognostic marker in lung cancer (favourable).
Lung cancer p<0.001
Show all

RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer

STAINING SUMMARY
HPA032139
HPA032140

GENE INFORMATION

Gene name

 SLC11A2 (HGNC Symbol)

Synonyms

 DCT1, DMT1, NRAMP2

Description

 Solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the solute carrier family 11 protein family. The product of this gene transports divalent metals and is involved in iron absorption. Mutations in this gene are associated with hypochromic microcytic anemia with iron overload. A related solute carrier family 11 protein gene is located on chromosome 2. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Apr 2010]

Chromosome

 12

Cytoband

 q13.12

Chromosome location (bp)

 50979401 - 51028566

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000110911 (version 83.38)

Entrez gene

 4891

UniProt

 P49281 (UniProt - Evidence at protein level)

neXtProt

 NX_P49281

Antibodypedia

 SLC11A2 antibodies

PROTEIN BROWSER
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SLC11A2-001
SLC11A2-002
SLC11A2-003
SLC11A2-005
SLC11A2-006
SLC11A2-007
SLC11A2-008
SLC11A2-010
SLC11A2-011
SLC11A2-012
SLC11A2-014
SLC11A2-017
SLC11A2-020
SLC11A2-025
SLC11A2-201
»

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SLC11A2-001
ENSP00000449200
ENST00000547688
P49281 [Direct mapping]
Natural resistance-associated macrophage protein 2
Show all
Transporters
   Electrochemical Potential-driven transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001666 [response to hypoxia]
GO:0003032 [detection of oxygen]
GO:0005215 [transporter activity]
GO:0005375 [copper ion transmembrane transporter activity]
GO:0005384 [manganese ion transmembrane transporter activity]
GO:0005385 [zinc ion transmembrane transporter activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005741 [mitochondrial outer membrane]
GO:0005764 [lysosome]
GO:0005765 [lysosomal membrane]
GO:0005769 [early endosome]
GO:0005770 [late endosome]
GO:0005773 [vacuole]
GO:0005802 [trans-Golgi network]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006810 [transport]
GO:0006824 [cobalt ion transport]
GO:0006825 [copper ion transport]
GO:0006828 [manganese ion transport]
GO:0006879 [cellular iron ion homeostasis]
GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0009986 [cell surface]
GO:0010039 [response to iron ion]
GO:0015086 [cadmium ion transmembrane transporter activity]
GO:0015087 [cobalt ion transmembrane transporter activity]
GO:0015093 [ferrous iron transmembrane transporter activity]
GO:0015094 [lead ion transmembrane transporter activity]
GO:0015099 [nickel cation transmembrane transporter activity]
GO:0015100 [vanadium ion transmembrane transporter activity]
GO:0015295 [solute:proton symporter activity]
GO:0015639 [ferrous iron uptake transmembrane transporter activity]
GO:0015675 [nickel cation transport]
GO:0015676 [vanadium ion transport]
GO:0015684 [ferrous iron transport]
GO:0015692 [lead ion transport]
GO:0016020 [membrane]
GO:0016324 [apical plasma membrane]
GO:0022890 [inorganic cation transmembrane transporter activity]
GO:0030904 [retromer complex]
GO:0031410 [cytoplasmic vesicle]
GO:0031902 [late endosome membrane]
GO:0033570 [transferrin transmembrane transporter activity]
GO:0033572 [transferrin transport]
GO:0034599 [cellular response to oxidative stress]
GO:0035434 [copper ion transmembrane transport]
GO:0035444 [nickel cation transmembrane transport]
GO:0045177 [apical part of cell]
GO:0045178 [basal part of cell]
GO:0046870 [cadmium ion binding]
GO:0046915 [transition metal ion transmembrane transporter activity]
GO:0048471 [perinuclear region of cytoplasm]
GO:0055037 [recycling endosome]
GO:0055085 [transmembrane transport]
GO:0060586 [multicellular organismal iron ion homeostasis]
GO:0070574 [cadmium ion transmembrane transport]
GO:0070627 [ferrous iron import]
GO:0070826 [paraferritin complex]
GO:0071421 [manganese ion transmembrane transport]
GO:0071577 [zinc II ion transmembrane transport]
GO:0098655 [cation transmembrane transport]
GO:1903874 [ferrous iron transmembrane transport]
Show all
 590 aa
64.7 kDa 		No >9
SLC11A2-002
ENSP00000262052
ENST00000262052
P49281 [Direct mapping]
Natural resistance-associated macrophage protein 2
Show all
Transporters
   Electrochemical Potential-driven transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001666 [response to hypoxia]
GO:0003032 [detection of oxygen]
GO:0005215 [transporter activity]
GO:0005375 [copper ion transmembrane transporter activity]
GO:0005384 [manganese ion transmembrane transporter activity]
GO:0005385 [zinc ion transmembrane transporter activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005741 [mitochondrial outer membrane]
GO:0005764 [lysosome]
GO:0005765 [lysosomal membrane]
GO:0005769 [early endosome]
GO:0005770 [late endosome]
GO:0005773 [vacuole]
GO:0005802 [trans-Golgi network]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006810 [transport]
GO:0006824 [cobalt ion transport]
GO:0006825 [copper ion transport]
GO:0006828 [manganese ion transport]
GO:0006879 [cellular iron ion homeostasis]
GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0009986 [cell surface]
GO:0010039 [response to iron ion]
GO:0015086 [cadmium ion transmembrane transporter activity]
GO:0015087 [cobalt ion transmembrane transporter activity]
GO:0015093 [ferrous iron transmembrane transporter activity]
GO:0015094 [lead ion transmembrane transporter activity]
GO:0015099 [nickel cation transmembrane transporter activity]
GO:0015100 [vanadium ion transmembrane transporter activity]
GO:0015295 [solute:proton symporter activity]
GO:0015639 [ferrous iron uptake transmembrane transporter activity]
GO:0015675 [nickel cation transport]
GO:0015676 [vanadium ion transport]
GO:0015684 [ferrous iron transport]
GO:0015692 [lead ion transport]
GO:0016020 [membrane]
GO:0016324 [apical plasma membrane]
GO:0022890 [inorganic cation transmembrane transporter activity]
GO:0030904 [retromer complex]
GO:0031410 [cytoplasmic vesicle]
GO:0031902 [late endosome membrane]
GO:0033570 [transferrin transmembrane transporter activity]
GO:0033572 [transferrin transport]
GO:0034599 [cellular response to oxidative stress]
GO:0035434 [copper ion transmembrane transport]
GO:0035444 [nickel cation transmembrane transport]
GO:0045177 [apical part of cell]
GO:0045178 [basal part of cell]
GO:0046870 [cadmium ion binding]
GO:0046915 [transition metal ion transmembrane transporter activity]
GO:0048471 [perinuclear region of cytoplasm]
GO:0055037 [recycling endosome]
GO:0055085 [transmembrane transport]
GO:0060586 [multicellular organismal iron ion homeostasis]
GO:0070574 [cadmium ion transmembrane transport]
GO:0070627 [ferrous iron import]
GO:0070826 [paraferritin complex]
GO:0071421 [manganese ion transmembrane transport]
GO:0071577 [zinc II ion transmembrane transport]
GO:0098655 [cation transmembrane transport]
GO:1903874 [ferrous iron transmembrane transport]
Show all
 561 aa
61.5 kDa 		No >9
SLC11A2-003
ENSP00000446914
ENST00000546743
F8W1P7 [Direct mapping]
Natural resistance-associated macrophage protein 2
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005215 [transporter activity]
GO:0006810 [transport]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
Show all
 482 aa
52.8 kDa 		No >9
SLC11A2-005
ENSP00000444542
ENST00000541174
P49281 [Direct mapping]
Natural resistance-associated macrophage protein 2
Show all
Transporters
   Electrochemical Potential-driven transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001666 [response to hypoxia]
GO:0003032 [detection of oxygen]
GO:0005215 [transporter activity]
GO:0005375 [copper ion transmembrane transporter activity]
GO:0005384 [manganese ion transmembrane transporter activity]
GO:0005385 [zinc ion transmembrane transporter activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005741 [mitochondrial outer membrane]
GO:0005764 [lysosome]
GO:0005765 [lysosomal membrane]
GO:0005769 [early endosome]
GO:0005770 [late endosome]
GO:0005773 [vacuole]
GO:0005802 [trans-Golgi network]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006810 [transport]
GO:0006824 [cobalt ion transport]
GO:0006825 [copper ion transport]
GO:0006828 [manganese ion transport]
GO:0006879 [cellular iron ion homeostasis]
GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0009986 [cell surface]
GO:0010039 [response to iron ion]
GO:0015086 [cadmium ion transmembrane transporter activity]
GO:0015087 [cobalt ion transmembrane transporter activity]
GO:0015093 [ferrous iron transmembrane transporter activity]
GO:0015094 [lead ion transmembrane transporter activity]
GO:0015099 [nickel cation transmembrane transporter activity]
GO:0015100 [vanadium ion transmembrane transporter activity]
GO:0015295 [solute:proton symporter activity]
GO:0015639 [ferrous iron uptake transmembrane transporter activity]
GO:0015675 [nickel cation transport]
GO:0015676 [vanadium ion transport]
GO:0015684 [ferrous iron transport]
GO:0015692 [lead ion transport]
GO:0016020 [membrane]
GO:0016324 [apical plasma membrane]
GO:0022890 [inorganic cation transmembrane transporter activity]
GO:0030904 [retromer complex]
GO:0031410 [cytoplasmic vesicle]
GO:0031902 [late endosome membrane]
GO:0033570 [transferrin transmembrane transporter activity]
GO:0033572 [transferrin transport]
GO:0034599 [cellular response to oxidative stress]
GO:0035434 [copper ion transmembrane transport]
GO:0035444 [nickel cation transmembrane transport]
GO:0045177 [apical part of cell]
GO:0045178 [basal part of cell]
GO:0046870 [cadmium ion binding]
GO:0046915 [transition metal ion transmembrane transporter activity]
GO:0048471 [perinuclear region of cytoplasm]
GO:0055037 [recycling endosome]
GO:0055085 [transmembrane transport]
GO:0060586 [multicellular organismal iron ion homeostasis]
GO:0070574 [cadmium ion transmembrane transport]
GO:0070627 [ferrous iron import]
GO:0070826 [paraferritin complex]
GO:0071421 [manganese ion transmembrane transport]
GO:0071577 [zinc II ion transmembrane transport]
GO:0098655 [cation transmembrane transport]
GO:1903874 [ferrous iron transmembrane transport]
Show all
 561 aa
61.5 kDa 		No >9
SLC11A2-006
ENSP00000262051
ENST00000262051
P49281 [Direct mapping]
Natural resistance-associated macrophage protein 2
Show all
Transporters
   Electrochemical Potential-driven transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001666 [response to hypoxia]
GO:0003032 [detection of oxygen]
GO:0005215 [transporter activity]
GO:0005375 [copper ion transmembrane transporter activity]
GO:0005384 [manganese ion transmembrane transporter activity]
GO:0005385 [zinc ion transmembrane transporter activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005741 [mitochondrial outer membrane]
GO:0005764 [lysosome]
GO:0005765 [lysosomal membrane]
GO:0005769 [early endosome]
GO:0005770 [late endosome]
GO:0005773 [vacuole]
GO:0005802 [trans-Golgi network]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006810 [transport]
GO:0006824 [cobalt ion transport]
GO:0006825 [copper ion transport]
GO:0006828 [manganese ion transport]
GO:0006879 [cellular iron ion homeostasis]
GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0009986 [cell surface]
GO:0010039 [response to iron ion]
GO:0015086 [cadmium ion transmembrane transporter activity]
GO:0015087 [cobalt ion transmembrane transporter activity]
GO:0015093 [ferrous iron transmembrane transporter activity]
GO:0015094 [lead ion transmembrane transporter activity]
GO:0015099 [nickel cation transmembrane transporter activity]
GO:0015100 [vanadium ion transmembrane transporter activity]
GO:0015295 [solute:proton symporter activity]
GO:0015639 [ferrous iron uptake transmembrane transporter activity]
GO:0015675 [nickel cation transport]
GO:0015676 [vanadium ion transport]
GO:0015684 [ferrous iron transport]
GO:0015692 [lead ion transport]
GO:0016020 [membrane]
GO:0016324 [apical plasma membrane]
GO:0022890 [inorganic cation transmembrane transporter activity]
GO:0030904 [retromer complex]
GO:0031410 [cytoplasmic vesicle]
GO:0031902 [late endosome membrane]
GO:0033570 [transferrin transmembrane transporter activity]
GO:0033572 [transferrin transport]
GO:0034599 [cellular response to oxidative stress]
GO:0035434 [copper ion transmembrane transport]
GO:0035444 [nickel cation transmembrane transport]
GO:0045177 [apical part of cell]
GO:0045178 [basal part of cell]
GO:0046870 [cadmium ion binding]
GO:0046915 [transition metal ion transmembrane transporter activity]
GO:0048471 [perinuclear region of cytoplasm]
GO:0055037 [recycling endosome]
GO:0055085 [transmembrane transport]
GO:0060586 [multicellular organismal iron ion homeostasis]
GO:0070574 [cadmium ion transmembrane transport]
GO:0070627 [ferrous iron import]
GO:0070826 [paraferritin complex]
GO:0071421 [manganese ion transmembrane transport]
GO:0071577 [zinc II ion transmembrane transport]
GO:0098655 [cation transmembrane transport]
GO:1903874 [ferrous iron transmembrane transport]
Show all
 568 aa
62.3 kDa 		No >9
SLC11A2-007
ENSP00000446769
ENST00000547198
P49281 [Direct mapping]
Natural resistance-associated macrophage protein 2
Show all
Transporters
   Electrochemical Potential-driven transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001666 [response to hypoxia]
GO:0003032 [detection of oxygen]
GO:0005215 [transporter activity]
GO:0005375 [copper ion transmembrane transporter activity]
GO:0005384 [manganese ion transmembrane transporter activity]
GO:0005385 [zinc ion transmembrane transporter activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005741 [mitochondrial outer membrane]
GO:0005764 [lysosome]
GO:0005765 [lysosomal membrane]
GO:0005769 [early endosome]
GO:0005770 [late endosome]
GO:0005773 [vacuole]
GO:0005802 [trans-Golgi network]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006810 [transport]
GO:0006824 [cobalt ion transport]
GO:0006825 [copper ion transport]
GO:0006828 [manganese ion transport]
GO:0006879 [cellular iron ion homeostasis]
GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0009986 [cell surface]
GO:0010039 [response to iron ion]
GO:0015086 [cadmium ion transmembrane transporter activity]
GO:0015087 [cobalt ion transmembrane transporter activity]
GO:0015093 [ferrous iron transmembrane transporter activity]
GO:0015094 [lead ion transmembrane transporter activity]
GO:0015099 [nickel cation transmembrane transporter activity]
GO:0015100 [vanadium ion transmembrane transporter activity]
GO:0015295 [solute:proton symporter activity]
GO:0015639 [ferrous iron uptake transmembrane transporter activity]
GO:0015675 [nickel cation transport]
GO:0015676 [vanadium ion transport]
GO:0015684 [ferrous iron transport]
GO:0015692 [lead ion transport]
GO:0016020 [membrane]
GO:0016324 [apical plasma membrane]
GO:0022890 [inorganic cation transmembrane transporter activity]
GO:0030904 [retromer complex]
GO:0031410 [cytoplasmic vesicle]
GO:0031902 [late endosome membrane]
GO:0033570 [transferrin transmembrane transporter activity]
GO:0033572 [transferrin transport]
GO:0034599 [cellular response to oxidative stress]
GO:0035434 [copper ion transmembrane transport]
GO:0035444 [nickel cation transmembrane transport]
GO:0045177 [apical part of cell]
GO:0045178 [basal part of cell]
GO:0046870 [cadmium ion binding]
GO:0046915 [transition metal ion transmembrane transporter activity]
GO:0048471 [perinuclear region of cytoplasm]
GO:0055037 [recycling endosome]
GO:0055085 [transmembrane transport]
GO:0060586 [multicellular organismal iron ion homeostasis]
GO:0070574 [cadmium ion transmembrane transport]
GO:0070627 [ferrous iron import]
GO:0070826 [paraferritin complex]
GO:0071421 [manganese ion transmembrane transport]
GO:0071577 [zinc II ion transmembrane transport]
GO:0098655 [cation transmembrane transport]
GO:1903874 [ferrous iron transmembrane transport]
Show all
 568 aa
62.3 kDa 		No >9
SLC11A2-008
ENSP00000442810
ENST00000545993
P49281 [Direct mapping]
Natural resistance-associated macrophage protein 2
Show all
Transporters
   Electrochemical Potential-driven transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001666 [response to hypoxia]
GO:0003032 [detection of oxygen]
GO:0005215 [transporter activity]
GO:0005375 [copper ion transmembrane transporter activity]
GO:0005384 [manganese ion transmembrane transporter activity]
GO:0005385 [zinc ion transmembrane transporter activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005741 [mitochondrial outer membrane]
GO:0005764 [lysosome]
GO:0005765 [lysosomal membrane]
GO:0005769 [early endosome]
GO:0005770 [late endosome]
GO:0005773 [vacuole]
GO:0005802 [trans-Golgi network]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006810 [transport]
GO:0006824 [cobalt ion transport]
GO:0006825 [copper ion transport]
GO:0006828 [manganese ion transport]
GO:0006879 [cellular iron ion homeostasis]
GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0009986 [cell surface]
GO:0010039 [response to iron ion]
GO:0015086 [cadmium ion transmembrane transporter activity]
GO:0015087 [cobalt ion transmembrane transporter activity]
GO:0015093 [ferrous iron transmembrane transporter activity]
GO:0015094 [lead ion transmembrane transporter activity]
GO:0015099 [nickel cation transmembrane transporter activity]
GO:0015100 [vanadium ion transmembrane transporter activity]
GO:0015295 [solute:proton symporter activity]
GO:0015639 [ferrous iron uptake transmembrane transporter activity]
GO:0015675 [nickel cation transport]
GO:0015676 [vanadium ion transport]
GO:0015684 [ferrous iron transport]
GO:0015692 [lead ion transport]
GO:0016020 [membrane]
GO:0016324 [apical plasma membrane]
GO:0022890 [inorganic cation transmembrane transporter activity]
GO:0030904 [retromer complex]
GO:0031410 [cytoplasmic vesicle]
GO:0031902 [late endosome membrane]
GO:0033570 [transferrin transmembrane transporter activity]
GO:0033572 [transferrin transport]
GO:0034599 [cellular response to oxidative stress]
GO:0035434 [copper ion transmembrane transport]
GO:0035444 [nickel cation transmembrane transport]
GO:0045177 [apical part of cell]
GO:0045178 [basal part of cell]
GO:0046870 [cadmium ion binding]
GO:0046915 [transition metal ion transmembrane transporter activity]
GO:0048471 [perinuclear region of cytoplasm]
GO:0055037 [recycling endosome]
GO:0055085 [transmembrane transport]
GO:0060586 [multicellular organismal iron ion homeostasis]
GO:0070574 [cadmium ion transmembrane transport]
GO:0070627 [ferrous iron import]
GO:0070826 [paraferritin complex]
GO:0071421 [manganese ion transmembrane transport]
GO:0071577 [zinc II ion transmembrane transport]
GO:0098655 [cation transmembrane transport]
GO:1903874 [ferrous iron transmembrane transport]
Show all
 557 aa
61 kDa 		No >9
SLC11A2-010
ENSP00000447482
ENST00000547579
F8W1F2 [Direct mapping]
Natural resistance-associated macrophage protein 2
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   4TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005215 [transporter activity]
GO:0006810 [transport]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
Show all
 150 aa
16.5 kDa 		No 4
SLC11A2-011
ENSP00000446984
ENST00000550714
F8W1C0 [Direct mapping]
Natural resistance-associated macrophage protein 2
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   4TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005215 [transporter activity]
GO:0006810 [transport]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
Show all
 148 aa
16.1 kDa 		No 4
SLC11A2-012
ENSP00000450389
ENST00000546488
F8VR36 [Direct mapping]
Natural resistance-associated macrophage protein 2
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Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   3TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
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GO:0005215 [transporter activity]
GO:0006810 [transport]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
Show all
 154 aa
16.9 kDa 		No 3
SLC11A2-014
ENSP00000447102
ENST00000547732
F8W154 [Direct mapping]
Natural resistance-associated macrophage protein 2
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Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   2TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005215 [transporter activity]
GO:0006810 [transport]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
Show all
 98 aa
10.6 kDa 		No 2
SLC11A2-017
ENSP00000447334
ENST00000549110
F8VZL6 [Direct mapping]
Natural resistance-associated macrophage protein 2
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   2TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005215 [transporter activity]
GO:0006810 [transport]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
Show all
 87 aa
9.5 kDa 		No 2
SLC11A2-020
ENSP00000449209
ENST00000548193
F8VWB0 [Direct mapping]
Natural resistance-associated macrophage protein 2
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   2TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005215 [transporter activity]
GO:0006810 [transport]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
Show all
 149 aa
16.3 kDa 		No 2
SLC11A2-025
ENSP00000448273
ENST00000548150
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 3 aa
0.4 kDa 		No 0
SLC11A2-201
ENSP00000378364
ENST00000394904
P49281 [Direct mapping]
Natural resistance-associated macrophage protein 2
Show all
Transporters
   Electrochemical Potential-driven transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001666 [response to hypoxia]
GO:0003032 [detection of oxygen]
GO:0005215 [transporter activity]
GO:0005375 [copper ion transmembrane transporter activity]
GO:0005381 [iron ion transmembrane transporter activity]
GO:0005384 [manganese ion transmembrane transporter activity]
GO:0005385 [zinc ion transmembrane transporter activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005741 [mitochondrial outer membrane]
GO:0005764 [lysosome]
GO:0005765 [lysosomal membrane]
GO:0005768 [endosome]
GO:0005769 [early endosome]
GO:0005770 [late endosome]
GO:0005773 [vacuole]
GO:0005802 [trans-Golgi network]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0005903 [brush border]
GO:0006778 [porphyrin-containing compound metabolic process]
GO:0006779 [porphyrin-containing compound biosynthetic process]
GO:0006783 [heme biosynthetic process]
GO:0006810 [transport]
GO:0006824 [cobalt ion transport]
GO:0006825 [copper ion transport]
GO:0006826 [iron ion transport]
GO:0006828 [manganese ion transport]
GO:0006879 [cellular iron ion homeostasis]
GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0007611 [learning or memory]
GO:0009986 [cell surface]
GO:0010039 [response to iron ion]
GO:0012505 [endomembrane system]
GO:0015078 [hydrogen ion transmembrane transporter activity]
GO:0015086 [cadmium ion transmembrane transporter activity]
GO:0015087 [cobalt ion transmembrane transporter activity]
GO:0015093 [ferrous iron transmembrane transporter activity]
GO:0015094 [lead ion transmembrane transporter activity]
GO:0015099 [nickel cation transmembrane transporter activity]
GO:0015100 [vanadium ion transmembrane transporter activity]
GO:0015295 [solute:proton symporter activity]
GO:0015639 [ferrous iron uptake transmembrane transporter activity]
GO:0015675 [nickel cation transport]
GO:0015676 [vanadium ion transport]
GO:0015684 [ferrous iron transport]
GO:0015692 [lead ion transport]
GO:0015992 [proton transport]
GO:0016020 [membrane]
GO:0016324 [apical plasma membrane]
GO:0022890 [inorganic cation transmembrane transporter activity]
GO:0030904 [retromer complex]
GO:0031410 [cytoplasmic vesicle]
GO:0031526 [brush border membrane]
GO:0031902 [late endosome membrane]
GO:0033570 [transferrin transmembrane transporter activity]
GO:0033572 [transferrin transport]
GO:0034599 [cellular response to oxidative stress]
GO:0035434 [copper ion transmembrane transport]
GO:0035444 [nickel cation transmembrane transport]
GO:0045177 [apical part of cell]
GO:0045178 [basal part of cell]
GO:0046870 [cadmium ion binding]
GO:0046915 [transition metal ion transmembrane transporter activity]
GO:0048471 [perinuclear region of cytoplasm]
GO:0048813 [dendrite morphogenesis]
GO:0048821 [erythrocyte development]
GO:0055037 [recycling endosome]
GO:0055085 [transmembrane transport]
GO:0060586 [multicellular organismal iron ion homeostasis]
GO:0070574 [cadmium ion transmembrane transport]
GO:0070627 [ferrous iron import]
GO:0070826 [paraferritin complex]
GO:0071421 [manganese ion transmembrane transport]
GO:0071577 [zinc II ion transmembrane transport]
GO:0098655 [cation transmembrane transport]
GO:1902600 [hydrogen ion transmembrane transport]
GO:1903874 [ferrous iron transmembrane transport]
Show all
 590 aa
64.7 kDa 		No >9

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.