Expression of CSRNP2 in cancer - Summary - The Human Protein Atlas

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CSRNP2

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	CSRNP2
Gene description	Cysteine-serine-rich nuclear protein 2
Protein class	Predicted intracellular proteins Transcription factors
Predicted localization	Intracellular
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

General cytoplasmic expression.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 1 antibody. HPA018503
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable), urothelial cancer (favourable) and renal cancer (unfavourable).
Liver cancer p<0.001 Urothelial cancer p<0.001 Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA018503

GENE INFORMATION
Gene name	CSRNP2 (HGNC Symbol)
Synonyms	C12ORF2, C12orf22, FAM130A1, PPP1R72, TAIP-12
Description	Cysteine-serine-rich nuclear protein 2 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene belongs to the CSRNP family of nuclear proteins that share conserved regions, including cysteine- and serine- rich regions, a basic domain, a transcriptional activation domain, and bind the sequence 'AGAGTG', thus have the hallmark of transcription factors. Studies in mice suggest that these genes may have redundant functions. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Aug 2011]
Chromosome	12
Cytoband	q13.12
Chromosome location (bp)	51061205 - 51083664
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000110925 (version 83.38)
Entrez gene	81566
UniProt	Q9H175 (UniProt - Evidence at protein level)
neXtProt	NX_Q9H175
Antibodypedia	CSRNP2 antibodies

PROTEIN BROWSER

CSRNP2-001	CSRNP2-003	CSRNP2-004	CSRNP2-006	CSRNP2-007

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CSRNP2-001 ENSP00000228515 ENST00000228515	Q9H175 [Direct mapping] Cysteine/serine-rich nuclear protein 2 Show all	Predicted intracellular proteins Transcription factors Yet undefined DNA-binding domains Protein evidence (Ezkurdia et al 2014) Show all	GO:0001228 [transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0006366 [transcription from RNA polymerase II promoter] GO:0006915 [apoptotic process] GO:0010923 [negative regulation of phosphatase activity] GO:0019902 [phosphatase binding] GO:0043565 [sequence-specific DNA binding] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] Show all	543 aa 59.6 kDa	No	0
CSRNP2-003 ENSP00000447657 ENST00000548981	F8VZY2 [Direct mapping] Cysteine/serine-rich nuclear protein 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		114 aa 12.6 kDa	No	0
CSRNP2-004 ENSP00000449152 ENST00000546935	F8VVN1 [Direct mapping] Cysteine/serine-rich nuclear protein 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		58 aa 6.1 kDa	No	0
CSRNP2-006 ENSP00000447983 ENST00000548206	F8VTU0 [Direct mapping] Cysteine/serine-rich nuclear protein 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		66 aa 7.7 kDa	No	0
CSRNP2-007 ENSP00000447065 ENST00000552899	F8W1G8 [Direct mapping] Cysteine/serine-rich nuclear protein 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		86 aa 9.5 kDa	No	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.