Expression of BIN2 in cancer - Summary - The Human Protein Atlas

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BIN2

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TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	BIN2
Gene description	Bridging integrator 2
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Cell line enhanced (HEL, HMC-1, NB-4, THP-1, U-937)
HPA (normal tissue):	Tissue enhanced (bone marrow)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in subsets of immune cells.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Presumed off target binding observed and disregarded.
Reliability score	Supported based on 2 antibodies. HPA038666 , HPA038667
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PROGNOSTIC SUMMARY
Prognostic marker in cervical cancer (favourable) and endometrial cancer (favourable).
Cervical cancer p<0.001 Endometrial cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA038666	HPA038667

GENE INFORMATION
Gene name	BIN2 (HGNC Symbol)
Synonyms	BRAP-1
Description	Bridging integrator 2 (HGNC Symbol)
Entrez gene summary
Chromosome	12
Cytoband	q13.13
Chromosome location (bp)	51281038 - 51324668
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000110934 (version 83.38)
Entrez gene	51411
UniProt
neXtProt
Antibodypedia	BIN2 antibodies

PROTEIN BROWSER

BIN2-001	BIN2-002	BIN2-004	BIN2-005

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
BIN2-001 ENSP00000483983 ENST00000615107	A0A087X188 [Direct mapping] Bridging integrator 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005737 [cytoplasm] Show all	597 aa 65 kDa	No	0
BIN2-002 ENSP00000445874 ENST00000544402	F5H0W4 [Direct mapping] Bridging integrator 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005737 [cytoplasm] Show all	539 aa 59.2 kDa	No	0
BIN2-004 ENSP00000410217 ENST00000452142	A0A0A0MT10 [Direct mapping] Bridging integrator 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005737 [cytoplasm] Show all	551 aa 59.7 kDa	No	0
BIN2-005 ENSP00000474972 ENST00000604560	S4R418 [Direct mapping] Bridging integrator 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005737 [cytoplasm] Show all	536 aa 58.9 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.