Expression of BCL7A in cancer - Summary - The Human Protein Atlas

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BCL7A

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	BCL7A
Gene description	B-cell CLL/lymphoma 7A
Protein class	Cancer-related genes Disease related genes Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Cell line enhanced (Daudi, U-698)
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Nuclear expression in most tissues, most abundant in lymphoid germinal centra.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 1 antibody. HPA019762
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable), liver cancer (unfavourable) and colorectal cancer (unfavourable).
Renal cancer p<0.001 Liver cancer p<0.001 Colorectal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA019762

GENE INFORMATION
Gene name	BCL7A (HGNC Symbol)
Synonyms	BCL7
Description	B-cell CLL/lymphoma 7A (HGNC Symbol)
Entrez gene summary	This gene is directly involved, with Myc and IgH, in a three-way gene translocation in a Burkitt lymphoma cell line. As a result of the gene translocation, the N-terminal region of the gene product is disrupted, which is thought to be related to the pathogenesis of a subset of high-grade B cell non-Hodgkin lymphoma. The N-terminal segment involved in the translocation includes the region that shares a strong sequence similarity with those of BCL7B and BCL7C. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Chromosome	12
Cytoband	q24.31
Chromosome location (bp)	122019422 - 122062044
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000110987 (version 83.38)
Entrez gene	605
UniProt	Q4VC05 (UniProt - Evidence at protein level)
neXtProt	NX_Q4VC05
Antibodypedia	BCL7A antibodies

PROTEIN BROWSER

BCL7A-001	BCL7A-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
BCL7A-001 ENSP00000445868 ENST00000538010	Q4VC05 [Direct mapping] B-cell CLL/lymphoma 7 protein family member A Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003674 [molecular_function] GO:0005515 [protein binding] GO:0005575 [cellular_component] GO:0045892 [negative regulation of transcription, DNA-templated] Show all	231 aa 25 kDa	No	0
BCL7A-002 ENSP00000261822 ENST00000261822	Q4VC05 [Direct mapping] B-cell CLL/lymphoma 7 protein family member A Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003674 [molecular_function] GO:0005515 [protein binding] GO:0005575 [cellular_component] GO:0045892 [negative regulation of transcription, DNA-templated] Show all	210 aa 22.8 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.