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GLI1

GENERAL INFORMATION

Gene name

 GLI1

Gene description

 GLI family zinc finger 1

Protein class

 Predicted intracellular proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 6
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Tissue enhanced (testis cancer)
HPA (cell line):Cell line enhanced (AN3-CA, RH-30)
HPA (normal tissue):Tissue enhanced (cervix, uterine, endometrium)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in several tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining not consistent with RNA expression data. External characterization data supports antibody staining.

Reliability score

 Uncertain based on 1 antibody.
CAB009460
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Tissue enhanced (testis cancer)

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
CAB009460

GENE INFORMATION

Gene name

 GLI1 (HGNC Symbol)

Synonyms

 GLI

Description

 GLI family zinc finger 1 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the Kruppel family of zinc finger proteins. The encoded transcription factor is activated by the sonic hedgehog signal transduction cascade and regulates stem cell proliferation. The activity and nuclear localization of this protein is negatively regulated by p53 in an inhibitory loop. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009]

Chromosome

 12

Cytoband

 q13.3

Chromosome location (bp)

 57460135 - 57472262

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000111087 (version 83.38)

Entrez gene

 2735

UniProt

 P08151 (UniProt - Evidence at protein level)

neXtProt

 NX_P08151

Antibodypedia

 GLI1 antibodies

PROTEIN BROWSER
GLI1-001
GLI1-003
GLI1-004
GLI1-005
GLI1-201
GLI1-202

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
GLI1-001
ENSP00000228682
ENST00000228682
P08151 [Direct mapping]
Zinc finger protein GLI1
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Predicted intracellular proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Protein evidence (Kim et al 2014)
Show all
GO:0001649 [osteoblast differentiation]
GO:0003677 [DNA binding]
GO:0003682 [chromatin binding]
GO:0003705 [transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005929 [cilium]
GO:0005930 [axoneme]
GO:0006351 [transcription, DNA-templated]
GO:0007224 [smoothened signaling pathway]
GO:0007283 [spermatogenesis]
GO:0007418 [ventral midline development]
GO:0008017 [microtubule binding]
GO:0008284 [positive regulation of cell proliferation]
GO:0008589 [regulation of smoothened signaling pathway]
GO:0009913 [epidermal cell differentiation]
GO:0009953 [dorsal/ventral pattern formation]
GO:0009954 [proximal/distal pattern formation]
GO:0021696 [cerebellar cortex morphogenesis]
GO:0021938 [smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation]
GO:0021983 [pituitary gland development]
GO:0030324 [lung development]
GO:0030335 [positive regulation of cell migration]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0043565 [sequence-specific DNA binding]
GO:0044212 [transcription regulatory region DNA binding]
GO:0045667 [regulation of osteoblast differentiation]
GO:0045740 [positive regulation of DNA replication]
GO:0045880 [positive regulation of smoothened signaling pathway]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046872 [metal ion binding]
GO:0048546 [digestive tract morphogenesis]
GO:0060032 [notochord regression]
GO:0072372 [primary cilium]
GO:0090090 [negative regulation of canonical Wnt signaling pathway]
GO:0097542 [ciliary tip]
GO:0097546 [ciliary base]
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 1106 aa
117.9 kDa 		No 0
GLI1-003
ENSP00000434408
ENST00000528467
P08151 [Direct mapping]
Zinc finger protein GLI1
Show all
Predicted intracellular proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Show all
GO:0001649 [osteoblast differentiation]
GO:0003677 [DNA binding]
GO:0003682 [chromatin binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006351 [transcription, DNA-templated]
GO:0007224 [smoothened signaling pathway]
GO:0008284 [positive regulation of cell proliferation]
GO:0008589 [regulation of smoothened signaling pathway]
GO:0009913 [epidermal cell differentiation]
GO:0030335 [positive regulation of cell migration]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0043565 [sequence-specific DNA binding]
GO:0044212 [transcription regulatory region DNA binding]
GO:0045740 [positive regulation of DNA replication]
GO:0045880 [positive regulation of smoothened signaling pathway]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046872 [metal ion binding]
GO:0048546 [digestive tract morphogenesis]
GO:0090090 [negative regulation of canonical Wnt signaling pathway]
GO:0097542 [ciliary tip]
GO:0097546 [ciliary base]
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 1065 aa
113.7 kDa 		No 0
GLI1-004
ENSP00000436671
ENST00000532291
E9PIB9 [Direct mapping]
Zinc finger protein GLI1
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Predicted intracellular proteins
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GO:0003676 [nucleic acid binding]
GO:0046872 [metal ion binding]
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 175 aa
19.8 kDa 		No 0
GLI1-005
ENSP00000434421
ENST00000528432
E9PQQ1 [Direct mapping]
Zinc finger protein GLI1
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Predicted intracellular proteins
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 129 aa
13.4 kDa 		No 0
GLI1-201
ENSP00000437607
ENST00000543426
P08151 [Direct mapping]
Zinc finger protein GLI1
Show all
Predicted intracellular proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Protein evidence (Kim et al 2014)
Show all
GO:0001649 [osteoblast differentiation]
GO:0003677 [DNA binding]
GO:0003682 [chromatin binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006351 [transcription, DNA-templated]
GO:0007224 [smoothened signaling pathway]
GO:0008284 [positive regulation of cell proliferation]
GO:0008589 [regulation of smoothened signaling pathway]
GO:0009913 [epidermal cell differentiation]
GO:0030335 [positive regulation of cell migration]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0043565 [sequence-specific DNA binding]
GO:0044212 [transcription regulatory region DNA binding]
GO:0045740 [positive regulation of DNA replication]
GO:0045880 [positive regulation of smoothened signaling pathway]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046872 [metal ion binding]
GO:0048546 [digestive tract morphogenesis]
GO:0090090 [negative regulation of canonical Wnt signaling pathway]
GO:0097542 [ciliary tip]
GO:0097546 [ciliary base]
Show all
 978 aa
104.6 kDa 		No 0
GLI1-202
ENSP00000441006
ENST00000546141
P08151 [Direct mapping]
Zinc finger protein GLI1
Show all
Predicted intracellular proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Protein evidence (Kim et al 2014)
Show all
GO:0001649 [osteoblast differentiation]
GO:0003677 [DNA binding]
GO:0003682 [chromatin binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006351 [transcription, DNA-templated]
GO:0007224 [smoothened signaling pathway]
GO:0008284 [positive regulation of cell proliferation]
GO:0008589 [regulation of smoothened signaling pathway]
GO:0009913 [epidermal cell differentiation]
GO:0030335 [positive regulation of cell migration]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0043565 [sequence-specific DNA binding]
GO:0044212 [transcription regulatory region DNA binding]
GO:0045740 [positive regulation of DNA replication]
GO:0045880 [positive regulation of smoothened signaling pathway]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046872 [metal ion binding]
GO:0048546 [digestive tract morphogenesis]
GO:0090090 [negative regulation of canonical Wnt signaling pathway]
GO:0097542 [ciliary tip]
GO:0097546 [ciliary base]
Show all
 1065 aa
113.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.