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LTA4H

GENERAL INFORMATION

Gene name

 LTA4H

Gene description

 Leukotriene A4 hydrolase

Protein class

 Cancer-related genes
Enzymes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Nuclear and cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 3 antibodies.
HPA008399 , HPA017017 , CAB015221
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PROGNOSTIC SUMMARY
Prognostic marker in lung cancer (favourable) and breast cancer (favourable).
Lung cancer p<0.001
Breast cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA008399
HPA017017
CAB015221

GENE INFORMATION

Gene name

 LTA4H

Synonyms

Description

 Leukotriene A4 hydrolase (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is an enzyme that contains both hydrolase and aminopeptidase activities. The hydrolase activity is used in the final step of the biosynthesis of leukotriene B4, a proinflammatory mediator. The aminopeptidase activity has been shown to degrade proline-glycine-proline (PGP), a neutrophil chemoattractant and biomarker for chronic obstructive pulmonary disease (COPD). Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2015]

Chromosome

 12

Cytoband

 q23.1

Chromosome location (bp)

 96000828 - 96043520

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000111144 (version 83.38)

Entrez gene

 4048

UniProt

 P09960 (UniProt - Evidence at protein level)

neXtProt

 NX_P09960

Antibodypedia

 LTA4H antibodies

PROTEIN BROWSER
LTA4H-001
LTA4H-002
LTA4H-003

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
LTA4H-001
ENSP00000228740
ENST00000228740
P09960 [Direct mapping]
Leukotriene A-4 hydrolase
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Enzymes
   ENZYME proteins
   Hydrolases
   Peptidases
   Metallopeptidases
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004177 [aminopeptidase activity]
GO:0004301 [epoxide hydrolase activity]
GO:0004463 [leukotriene-A4 hydrolase activity]
GO:0005488 [binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006508 [proteolysis]
GO:0006691 [leukotriene metabolic process]
GO:0006954 [inflammatory response]
GO:0008233 [peptidase activity]
GO:0008237 [metallopeptidase activity]
GO:0008270 [zinc ion binding]
GO:0010043 [response to zinc ion]
GO:0019369 [arachidonic acid metabolic process]
GO:0019370 [leukotriene biosynthetic process]
GO:0042277 [peptide binding]
GO:0043171 [peptide catabolic process]
GO:0043434 [response to peptide hormone]
GO:0044281 [small molecule metabolic process]
GO:0044822 [poly(A) RNA binding]
GO:0060509 [Type I pneumocyte differentiation]
GO:0070006 [metalloaminopeptidase activity]
GO:0070062 [extracellular exosome]
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 611 aa
69.3 kDa 		No 0
LTA4H-002
ENSP00000395051
ENST00000413268
P09960 [Direct mapping]
Leukotriene A-4 hydrolase
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Enzymes
   ENZYME proteins
   Hydrolases
   Peptidases
   Metallopeptidases
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004177 [aminopeptidase activity]
GO:0004301 [epoxide hydrolase activity]
GO:0004463 [leukotriene-A4 hydrolase activity]
GO:0005488 [binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006508 [proteolysis]
GO:0006691 [leukotriene metabolic process]
GO:0006954 [inflammatory response]
GO:0008233 [peptidase activity]
GO:0008237 [metallopeptidase activity]
GO:0008270 [zinc ion binding]
GO:0019369 [arachidonic acid metabolic process]
GO:0019370 [leukotriene biosynthetic process]
GO:0042277 [peptide binding]
GO:0043171 [peptide catabolic process]
GO:0044281 [small molecule metabolic process]
GO:0044822 [poly(A) RNA binding]
GO:0070006 [metalloaminopeptidase activity]
GO:0070062 [extracellular exosome]
Show all
 508 aa
57.3 kDa 		No 0
LTA4H-003
ENSP00000449958
ENST00000552789
P09960 [Direct mapping]
Leukotriene A-4 hydrolase
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   Peptidases
   Metallopeptidases
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004177 [aminopeptidase activity]
GO:0004301 [epoxide hydrolase activity]
GO:0004463 [leukotriene-A4 hydrolase activity]
GO:0005488 [binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006508 [proteolysis]
GO:0006691 [leukotriene metabolic process]
GO:0006954 [inflammatory response]
GO:0008233 [peptidase activity]
GO:0008237 [metallopeptidase activity]
GO:0008270 [zinc ion binding]
GO:0019369 [arachidonic acid metabolic process]
GO:0019370 [leukotriene biosynthetic process]
GO:0042277 [peptide binding]
GO:0043171 [peptide catabolic process]
GO:0044281 [small molecule metabolic process]
GO:0044822 [poly(A) RNA binding]
GO:0070006 [metalloaminopeptidase activity]
GO:0070062 [extracellular exosome]
Show all
 587 aa
66.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.