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SLC6A12

GENERAL INFORMATION

Gene name

 SLC6A12

Gene description

 Solute carrier family 6 (neurotransmitter transporter), member 12

Protein class

 Predicted intracellular proteins
Predicted membrane proteins
Transporters

Predicted localization

 Intracellular,Membrane

Number of transcripts

 6
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Tissue enhanced (renal cancer)
HPA (cell line):Group enriched (Hep G2, RPTEC TERT1)
HPA (normal tissue):Tissue enhanced (kidney, liver)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic and membranous expression in several tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
HPA034973
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable) and endometrial cancer (unfavourable).
Renal cancer p<0.001
Endometrial cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Tissue enhanced (renal cancer)

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer

STAINING SUMMARY
HPA034973

GENE INFORMATION

Gene name

 SLC6A12 (HGNC Symbol)

Synonyms

 BGT-1

Description

 Solute carrier family 6 (neurotransmitter transporter), member 12 (HGNC Symbol)

Entrez gene summary

Chromosome

 12

Cytoband

 p13.33

Chromosome location (bp)

 190077 - 214570

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000111181 (version 83.38)

Entrez gene

 6539

UniProt

 P48065 (UniProt - Evidence at protein level)

neXtProt

 NX_P48065

Antibodypedia

 SLC6A12 antibodies

PROTEIN BROWSER
SLC6A12-001
SLC6A12-002
SLC6A12-004
SLC6A12-005
SLC6A12-008
SLC6A12-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SLC6A12-001
ENSP00000352702
ENST00000359674
P48065 [Direct mapping]
Sodium- and chloride-dependent betaine transporter
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Transporters
   Electrochemical Potential-driven transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Show all
GO:0005328 [neurotransmitter:sodium symporter activity]
GO:0005332 [gamma-aminobutyric acid:sodium symporter activity]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006810 [transport]
GO:0006811 [ion transport]
GO:0006836 [neurotransmitter transport]
GO:0006865 [amino acid transport]
GO:0007268 [synaptic transmission]
GO:0007269 [neurotransmitter secretion]
GO:0015812 [gamma-aminobutyric acid transport]
GO:0016021 [integral component of membrane]
GO:0043005 [neuron projection]
GO:0055085 [transmembrane transport]
Show all
 614 aa
69.4 kDa 		No >9
SLC6A12-002
ENSP00000399136
ENST00000424061
P48065 [Direct mapping]
Sodium- and chloride-dependent betaine transporter
Show all
Transporters
   Electrochemical Potential-driven transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Show all
GO:0005328 [neurotransmitter:sodium symporter activity]
GO:0005332 [gamma-aminobutyric acid:sodium symporter activity]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006810 [transport]
GO:0006811 [ion transport]
GO:0006836 [neurotransmitter transport]
GO:0006865 [amino acid transport]
GO:0007268 [synaptic transmission]
GO:0007269 [neurotransmitter secretion]
GO:0009992 [cellular water homeostasis]
GO:0010033 [response to organic substance]
GO:0015812 [gamma-aminobutyric acid transport]
GO:0016021 [integral component of membrane]
GO:0043005 [neuron projection]
GO:0055085 [transmembrane transport]
GO:0071474 [cellular hyperosmotic response]
Show all
 614 aa
69.4 kDa 		No >9
SLC6A12-004
ENSP00000444268
ENST00000536824
P48065 [Direct mapping]
Sodium- and chloride-dependent betaine transporter
Show all
Transporters
   Electrochemical Potential-driven transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Show all
GO:0005328 [neurotransmitter:sodium symporter activity]
GO:0005332 [gamma-aminobutyric acid:sodium symporter activity]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006810 [transport]
GO:0006811 [ion transport]
GO:0006836 [neurotransmitter transport]
GO:0006865 [amino acid transport]
GO:0007268 [synaptic transmission]
GO:0007269 [neurotransmitter secretion]
GO:0015812 [gamma-aminobutyric acid transport]
GO:0016021 [integral component of membrane]
GO:0043005 [neuron projection]
GO:0055085 [transmembrane transport]
Show all
 614 aa
69.4 kDa 		No >9
SLC6A12-005
ENSP00000439351
ENST00000537793
F5H2T6 [Direct mapping]
Transporter
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   3TM proteins predicted by MDM
Show all
GO:0005328 [neurotransmitter:sodium symporter activity]
GO:0006836 [neurotransmitter transport]
GO:0016021 [integral component of membrane]
GO:0055085 [transmembrane transport]
Show all
 146 aa
16.5 kDa 		No 3
SLC6A12-008
ENSP00000446082
ENST00000535347
F5H4L6 [Direct mapping]
Sodium- and chloride-dependent betaine transporter
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Predicted intracellular proteins
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 81 aa
8.7 kDa 		No 0
SLC6A12-201
ENSP00000380464
ENST00000397296
P48065 [Direct mapping]
Sodium- and chloride-dependent betaine transporter
Show all
Transporters
   Electrochemical Potential-driven transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Show all
GO:0005328 [neurotransmitter:sodium symporter activity]
GO:0005332 [gamma-aminobutyric acid:sodium symporter activity]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006810 [transport]
GO:0006811 [ion transport]
GO:0006836 [neurotransmitter transport]
GO:0006865 [amino acid transport]
GO:0007268 [synaptic transmission]
GO:0007269 [neurotransmitter secretion]
GO:0015812 [gamma-aminobutyric acid transport]
GO:0016021 [integral component of membrane]
GO:0043005 [neuron projection]
GO:0055085 [transmembrane transport]
Show all
 614 aa
69.4 kDa 		No >9

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.