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TRPV4

GENERAL INFORMATION

Gene name

 TRPV4

Gene description

 Transient receptor potential cation channel, subfamily V, member 4

Protein class

 Disease related genes
Potential drug targets
Predicted membrane proteins
Voltage-gated ion channels

Predicted localization

 Membrane

Number of transcripts

 6
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Mixed
GTEx:Tissue enhanced (salivary gland)
FANTOM5:Tissue enhanced (salivary gland)

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic and membranous expression in several tissues.

DATA RELIABILITY

Data reliability
description

 Antibody staining not consistent with RNA expression data. Pending external verification.

Reliability score

 Uncertain based on 1 antibody.
HPA007150
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Pancreas

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (salivary gland)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (salivary gland)

GENE INFORMATION

Gene name

 TRPV4 (HGNC Symbol)

Synonyms

 CMT2C, OTRPC4, TRP12, VR-OAC, VRL-2, VROAC

Description

 Transient receptor potential cation channel, subfamily V, member 4 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the OSM9-like transient receptor potential channel (OTRPC) subfamily in the transient receptor potential (TRP) superfamily of ion channels. The encoded protein is a Ca2+-permeable, nonselective cation channel that is thought to be involved in the regulation of systemic osmotic pressure. Mutations in this gene are the cause of spondylometaphyseal and metatropic dysplasia and hereditary motor and sensory neuropathy type IIC. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2010]

Chromosome

 12

Cytoband

 q24.11

Chromosome location (bp)

 109783085 - 109833401

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000111199 (version 83.38)

Entrez gene

 59341

UniProt

 Q9HBA0 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9HBA0

Antibodypedia

 TRPV4 antibodies

PROTEIN BROWSER
TRPV4-001
TRPV4-002
TRPV4-003
TRPV4-004
TRPV4-005
TRPV4-006

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
TRPV4-001
ENSP00000261740
ENST00000261740
Q9HBA0 [Direct mapping]
Transient receptor potential cation channel subfamily V member 4
Show all
Voltage-gated ion channels
   Transient Receptor Potential Channels
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   6TM proteins predicted by MDM
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0005080 [protein kinase C binding]
GO:0005216 [ion channel activity]
GO:0005261 [cation channel activity]
GO:0005262 [calcium channel activity]
GO:0005515 [protein binding]
GO:0005516 [calmodulin binding]
GO:0005524 [ATP binding]
GO:0005829 [cytosol]
GO:0005881 [cytoplasmic microtubule]
GO:0005886 [plasma membrane]
GO:0005912 [adherens junction]
GO:0005925 [focal adhesion]
GO:0005929 [cilium]
GO:0006811 [ion transport]
GO:0006816 [calcium ion transport]
GO:0006874 [cellular calcium ion homeostasis]
GO:0006884 [cell volume homeostasis]
GO:0007015 [actin filament organization]
GO:0007043 [cell-cell junction assembly]
GO:0007204 [positive regulation of cytosolic calcium ion concentration]
GO:0007231 [osmosensory signaling pathway]
GO:0008017 [microtubule binding]
GO:0009612 [response to mechanical stimulus]
GO:0010977 [negative regulation of neuron projection development]
GO:0015275 [stretch-activated, cation-selective, calcium channel activity]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016324 [apical plasma membrane]
GO:0019901 [protein kinase binding]
GO:0030027 [lamellipodium]
GO:0030175 [filopodium]
GO:0030426 [growth cone]
GO:0030864 [cortical actin cytoskeleton]
GO:0031117 [positive regulation of microtubule depolymerization]
GO:0031532 [actin cytoskeleton reorganization]
GO:0032587 [ruffle membrane]
GO:0034220 [ion transmembrane transport]
GO:0034605 [cellular response to heat]
GO:0042169 [SH2 domain binding]
GO:0043014 [alpha-tubulin binding]
GO:0043117 [positive regulation of vascular permeability]
GO:0043622 [cortical microtubule organization]
GO:0046785 [microtubule polymerization]
GO:0048487 [beta-tubulin binding]
GO:0050891 [multicellular organismal water homeostasis]
GO:0051015 [actin filament binding]
GO:0055085 [transmembrane transport]
GO:0070509 [calcium ion import]
GO:0070588 [calcium ion transmembrane transport]
GO:0071470 [cellular response to osmotic stress]
GO:0071476 [cellular hypotonic response]
GO:0097497 [blood vessel endothelial cell delamination]
Show all
 871 aa
98.3 kDa 		No 6
TRPV4-002
ENSP00000443611
ENST00000544971
Q9HBA0 [Direct mapping]
Transient receptor potential cation channel subfamily V member 4
Show all
Voltage-gated ion channels
   Transient Receptor Potential Channels
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   6TM proteins predicted by MDM
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0005080 [protein kinase C binding]
GO:0005216 [ion channel activity]
GO:0005261 [cation channel activity]
GO:0005262 [calcium channel activity]
GO:0005515 [protein binding]
GO:0005516 [calmodulin binding]
GO:0005524 [ATP binding]
GO:0005829 [cytosol]
GO:0005881 [cytoplasmic microtubule]
GO:0005886 [plasma membrane]
GO:0005912 [adherens junction]
GO:0005925 [focal adhesion]
GO:0005929 [cilium]
GO:0006811 [ion transport]
GO:0006816 [calcium ion transport]
GO:0006874 [cellular calcium ion homeostasis]
GO:0006884 [cell volume homeostasis]
GO:0007015 [actin filament organization]
GO:0007043 [cell-cell junction assembly]
GO:0007204 [positive regulation of cytosolic calcium ion concentration]
GO:0007231 [osmosensory signaling pathway]
GO:0008017 [microtubule binding]
GO:0009612 [response to mechanical stimulus]
GO:0010977 [negative regulation of neuron projection development]
GO:0015275 [stretch-activated, cation-selective, calcium channel activity]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016324 [apical plasma membrane]
GO:0019901 [protein kinase binding]
GO:0030027 [lamellipodium]
GO:0030175 [filopodium]
GO:0030426 [growth cone]
GO:0030864 [cortical actin cytoskeleton]
GO:0031117 [positive regulation of microtubule depolymerization]
GO:0031532 [actin cytoskeleton reorganization]
GO:0032587 [ruffle membrane]
GO:0034220 [ion transmembrane transport]
GO:0034605 [cellular response to heat]
GO:0042169 [SH2 domain binding]
GO:0043014 [alpha-tubulin binding]
GO:0043117 [positive regulation of vascular permeability]
GO:0043622 [cortical microtubule organization]
GO:0046785 [microtubule polymerization]
GO:0048487 [beta-tubulin binding]
GO:0050891 [multicellular organismal water homeostasis]
GO:0051015 [actin filament binding]
GO:0055085 [transmembrane transport]
GO:0070509 [calcium ion import]
GO:0070588 [calcium ion transmembrane transport]
GO:0071470 [cellular response to osmotic stress]
GO:0071476 [cellular hypotonic response]
GO:0097497 [blood vessel endothelial cell delamination]
Show all
 764 aa
85.9 kDa 		No 6
TRPV4-003
ENSP00000442738
ENST00000537083
Q9HBA0 [Direct mapping]
Transient receptor potential cation channel subfamily V member 4
Show all
Voltage-gated ion channels
   Transient Receptor Potential Channels
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   6TM proteins predicted by MDM
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0005080 [protein kinase C binding]
GO:0005216 [ion channel activity]
GO:0005261 [cation channel activity]
GO:0005262 [calcium channel activity]
GO:0005515 [protein binding]
GO:0005516 [calmodulin binding]
GO:0005524 [ATP binding]
GO:0005829 [cytosol]
GO:0005881 [cytoplasmic microtubule]
GO:0005886 [plasma membrane]
GO:0005912 [adherens junction]
GO:0005925 [focal adhesion]
GO:0005929 [cilium]
GO:0006811 [ion transport]
GO:0006816 [calcium ion transport]
GO:0006874 [cellular calcium ion homeostasis]
GO:0006884 [cell volume homeostasis]
GO:0007015 [actin filament organization]
GO:0007043 [cell-cell junction assembly]
GO:0007204 [positive regulation of cytosolic calcium ion concentration]
GO:0007231 [osmosensory signaling pathway]
GO:0008017 [microtubule binding]
GO:0009612 [response to mechanical stimulus]
GO:0010977 [negative regulation of neuron projection development]
GO:0015275 [stretch-activated, cation-selective, calcium channel activity]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016324 [apical plasma membrane]
GO:0019901 [protein kinase binding]
GO:0030027 [lamellipodium]
GO:0030175 [filopodium]
GO:0030426 [growth cone]
GO:0030864 [cortical actin cytoskeleton]
GO:0031117 [positive regulation of microtubule depolymerization]
GO:0031532 [actin cytoskeleton reorganization]
GO:0032587 [ruffle membrane]
GO:0034220 [ion transmembrane transport]
GO:0034605 [cellular response to heat]
GO:0042169 [SH2 domain binding]
GO:0043014 [alpha-tubulin binding]
GO:0043117 [positive regulation of vascular permeability]
GO:0043622 [cortical microtubule organization]
GO:0046785 [microtubule polymerization]
GO:0048487 [beta-tubulin binding]
GO:0050891 [multicellular organismal water homeostasis]
GO:0051015 [actin filament binding]
GO:0055085 [transmembrane transport]
GO:0070509 [calcium ion import]
GO:0070588 [calcium ion transmembrane transport]
GO:0071470 [cellular response to osmotic stress]
GO:0071476 [cellular hypotonic response]
GO:0097497 [blood vessel endothelial cell delamination]
Show all
 811 aa
91.3 kDa 		No 6
TRPV4-004
ENSP00000442167
ENST00000541794
Q9HBA0 [Direct mapping]
Transient receptor potential cation channel subfamily V member 4
Show all
Voltage-gated ion channels
   Transient Receptor Potential Channels
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   6TM proteins predicted by MDM
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0005080 [protein kinase C binding]
GO:0005216 [ion channel activity]
GO:0005261 [cation channel activity]
GO:0005262 [calcium channel activity]
GO:0005515 [protein binding]
GO:0005516 [calmodulin binding]
GO:0005524 [ATP binding]
GO:0005829 [cytosol]
GO:0005881 [cytoplasmic microtubule]
GO:0005886 [plasma membrane]
GO:0005912 [adherens junction]
GO:0005925 [focal adhesion]
GO:0005929 [cilium]
GO:0006811 [ion transport]
GO:0006816 [calcium ion transport]
GO:0006874 [cellular calcium ion homeostasis]
GO:0006884 [cell volume homeostasis]
GO:0007015 [actin filament organization]
GO:0007043 [cell-cell junction assembly]
GO:0007204 [positive regulation of cytosolic calcium ion concentration]
GO:0007231 [osmosensory signaling pathway]
GO:0008017 [microtubule binding]
GO:0009612 [response to mechanical stimulus]
GO:0010977 [negative regulation of neuron projection development]
GO:0015275 [stretch-activated, cation-selective, calcium channel activity]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016324 [apical plasma membrane]
GO:0019901 [protein kinase binding]
GO:0030027 [lamellipodium]
GO:0030175 [filopodium]
GO:0030426 [growth cone]
GO:0030864 [cortical actin cytoskeleton]
GO:0031117 [positive regulation of microtubule depolymerization]
GO:0031532 [actin cytoskeleton reorganization]
GO:0032587 [ruffle membrane]
GO:0034220 [ion transmembrane transport]
GO:0034605 [cellular response to heat]
GO:0042169 [SH2 domain binding]
GO:0043014 [alpha-tubulin binding]
GO:0043117 [positive regulation of vascular permeability]
GO:0043622 [cortical microtubule organization]
GO:0046785 [microtubule polymerization]
GO:0048487 [beta-tubulin binding]
GO:0050891 [multicellular organismal water homeostasis]
GO:0051015 [actin filament binding]
GO:0055085 [transmembrane transport]
GO:0070509 [calcium ion import]
GO:0070588 [calcium ion transmembrane transport]
GO:0071470 [cellular response to osmotic stress]
GO:0071476 [cellular hypotonic response]
GO:0097497 [blood vessel endothelial cell delamination]
Show all
 824 aa
92.9 kDa 		No 6
TRPV4-005
ENSP00000444336
ENST00000536838
Q9HBA0 [Direct mapping]
Transient receptor potential cation channel subfamily V member 4
Show all
Voltage-gated ion channels
   Transient Receptor Potential Channels
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   6TM proteins predicted by MDM
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0005080 [protein kinase C binding]
GO:0005216 [ion channel activity]
GO:0005261 [cation channel activity]
GO:0005262 [calcium channel activity]
GO:0005515 [protein binding]
GO:0005516 [calmodulin binding]
GO:0005524 [ATP binding]
GO:0005829 [cytosol]
GO:0005881 [cytoplasmic microtubule]
GO:0005886 [plasma membrane]
GO:0005912 [adherens junction]
GO:0005925 [focal adhesion]
GO:0005929 [cilium]
GO:0006811 [ion transport]
GO:0006816 [calcium ion transport]
GO:0006874 [cellular calcium ion homeostasis]
GO:0006884 [cell volume homeostasis]
GO:0007015 [actin filament organization]
GO:0007043 [cell-cell junction assembly]
GO:0007204 [positive regulation of cytosolic calcium ion concentration]
GO:0007231 [osmosensory signaling pathway]
GO:0008017 [microtubule binding]
GO:0009612 [response to mechanical stimulus]
GO:0010977 [negative regulation of neuron projection development]
GO:0015275 [stretch-activated, cation-selective, calcium channel activity]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016324 [apical plasma membrane]
GO:0019901 [protein kinase binding]
GO:0030027 [lamellipodium]
GO:0030175 [filopodium]
GO:0030426 [growth cone]
GO:0030864 [cortical actin cytoskeleton]
GO:0031117 [positive regulation of microtubule depolymerization]
GO:0031532 [actin cytoskeleton reorganization]
GO:0032587 [ruffle membrane]
GO:0034220 [ion transmembrane transport]
GO:0034605 [cellular response to heat]
GO:0042169 [SH2 domain binding]
GO:0043014 [alpha-tubulin binding]
GO:0043117 [positive regulation of vascular permeability]
GO:0043622 [cortical microtubule organization]
GO:0046785 [microtubule polymerization]
GO:0048487 [beta-tubulin binding]
GO:0050891 [multicellular organismal water homeostasis]
GO:0051015 [actin filament binding]
GO:0055085 [transmembrane transport]
GO:0070509 [calcium ion import]
GO:0070588 [calcium ion transmembrane transport]
GO:0071470 [cellular response to osmotic stress]
GO:0071476 [cellular hypotonic response]
GO:0097497 [blood vessel endothelial cell delamination]
Show all
 837 aa
95 kDa 		No 6
TRPV4-006
ENSP00000406191
ENST00000418703
Q9HBA0 [Direct mapping]
Transient receptor potential cation channel subfamily V member 4
Show all
Voltage-gated ion channels
   Transient Receptor Potential Channels
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   6TM proteins predicted by MDM
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0005034 [osmosensor activity]
GO:0005080 [protein kinase C binding]
GO:0005216 [ion channel activity]
GO:0005261 [cation channel activity]
GO:0005262 [calcium channel activity]
GO:0005515 [protein binding]
GO:0005516 [calmodulin binding]
GO:0005524 [ATP binding]
GO:0005829 [cytosol]
GO:0005881 [cytoplasmic microtubule]
GO:0005886 [plasma membrane]
GO:0005912 [adherens junction]
GO:0005925 [focal adhesion]
GO:0005929 [cilium]
GO:0006811 [ion transport]
GO:0006816 [calcium ion transport]
GO:0006874 [cellular calcium ion homeostasis]
GO:0006884 [cell volume homeostasis]
GO:0006970 [response to osmotic stress]
GO:0006971 [hypotonic response]
GO:0007015 [actin filament organization]
GO:0007043 [cell-cell junction assembly]
GO:0007204 [positive regulation of cytosolic calcium ion concentration]
GO:0007231 [osmosensory signaling pathway]
GO:0008017 [microtubule binding]
GO:0009612 [response to mechanical stimulus]
GO:0009986 [cell surface]
GO:0010977 [negative regulation of neuron projection development]
GO:0015275 [stretch-activated, cation-selective, calcium channel activity]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0016324 [apical plasma membrane]
GO:0019901 [protein kinase binding]
GO:0030027 [lamellipodium]
GO:0030103 [vasopressin secretion]
GO:0030175 [filopodium]
GO:0030426 [growth cone]
GO:0030864 [cortical actin cytoskeleton]
GO:0031117 [positive regulation of microtubule depolymerization]
GO:0031410 [cytoplasmic vesicle]
GO:0031532 [actin cytoskeleton reorganization]
GO:0032587 [ruffle membrane]
GO:0034220 [ion transmembrane transport]
GO:0034605 [cellular response to heat]
GO:0042169 [SH2 domain binding]
GO:0042538 [hyperosmotic salinity response]
GO:0043014 [alpha-tubulin binding]
GO:0043117 [positive regulation of vascular permeability]
GO:0043622 [cortical microtubule organization]
GO:0046785 [microtubule polymerization]
GO:0047484 [regulation of response to osmotic stress]
GO:0048487 [beta-tubulin binding]
GO:0050891 [multicellular organismal water homeostasis]
GO:0051015 [actin filament binding]
GO:0055085 [transmembrane transport]
GO:0070509 [calcium ion import]
GO:0070588 [calcium ion transmembrane transport]
GO:0071470 [cellular response to osmotic stress]
GO:0071476 [cellular hypotonic response]
GO:0097497 [blood vessel endothelial cell delamination]
Show all
 871 aa
98.3 kDa 		No 6

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.