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FOXM1

GENERAL INFORMATION

Gene name

 FOXM1

Gene description

 Forkhead box M1

Protein class

 Cancer-related genes
Predicted intracellular proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Tissue enhanced (testis)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Mainly nuclear expression in most tissues, highest expression in testis.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Pending retesting.

Reliability score

 Uncertain based on 2 antibodies.
HPA029974 , CAB017832
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable), liver cancer (unfavourable), pancreatic cancer (unfavourable) and lung cancer (unfavourable).
Renal cancer p<0.001
Liver cancer p<0.001
Pancreatic cancer p<0.001
Lung cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA029974
CAB017832

GENE INFORMATION

Gene name

 FOXM1 (HGNC Symbol)

Synonyms

 FKHL16, HFH-11, HNF-3, INS-1, MPHOSPH2, MPP2, TGT3, trident

Description

 Forkhead box M1 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a transcriptional activator involved in cell proliferation. The encoded protein is phosphorylated in M phase and regulates the expression of several cell cycle genes, such as cyclin B1 and cyclin D1. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2011]

Chromosome

 12

Cytoband

 p13.33

Chromosome location (bp)

 2857681 - 2877155

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000111206 (version 83.38)

Entrez gene

 2305

UniProt

 Q08050 (UniProt - Evidence at protein level)

neXtProt

 NX_Q08050

Antibodypedia

 FOXM1 antibodies

PROTEIN BROWSER
FOXM1-001
FOXM1-002
FOXM1-003
FOXM1-009
FOXM1-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
FOXM1-001
ENSP00000354492
ENST00000361953
Q08050 [Direct mapping]
Forkhead box protein M1
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Predicted intracellular proteins
Transcription factors
   Helix-turn-helix domains
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000086 [G2/M transition of mitotic cell cycle]
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000278 [mitotic cell cycle]
GO:0000981 [RNA polymerase II transcription factor activity, sequence-specific DNA binding]
GO:0001558 [regulation of cell growth]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006281 [DNA repair]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0006978 [DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator]
GO:0007049 [cell cycle]
GO:0008284 [positive regulation of cell proliferation]
GO:0009653 [anatomical structure morphogenesis]
GO:0019901 [protein kinase binding]
GO:0030154 [cell differentiation]
GO:0032873 [negative regulation of stress-activated MAPK cascade]
GO:0042127 [regulation of cell proliferation]
GO:0043565 [sequence-specific DNA binding]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046578 [regulation of Ras protein signal transduction]
GO:0051726 [regulation of cell cycle]
GO:0071156 [regulation of cell cycle arrest]
GO:0090344 [negative regulation of cell aging]
GO:2000377 [regulation of reactive oxygen species metabolic process]
GO:2000781 [positive regulation of double-strand break repair]
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 748 aa
82.7 kDa 		No 0
FOXM1-002
ENSP00000352901
ENST00000359843
Q08050 [Direct mapping]
Forkhead box protein M1
Q53Y49 [Target identity:100%; Query identity:100%]
Forkhead box M1; Forkhead box M1, isoform CRA_a; PIG29
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Predicted intracellular proteins
Transcription factors
   Helix-turn-helix domains
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000086 [G2/M transition of mitotic cell cycle]
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000278 [mitotic cell cycle]
GO:0000981 [RNA polymerase II transcription factor activity, sequence-specific DNA binding]
GO:0001558 [regulation of cell growth]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006281 [DNA repair]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0006978 [DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator]
GO:0007049 [cell cycle]
GO:0008284 [positive regulation of cell proliferation]
GO:0009653 [anatomical structure morphogenesis]
GO:0019901 [protein kinase binding]
GO:0030154 [cell differentiation]
GO:0032873 [negative regulation of stress-activated MAPK cascade]
GO:0042127 [regulation of cell proliferation]
GO:0043565 [sequence-specific DNA binding]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046578 [regulation of Ras protein signal transduction]
GO:0051726 [regulation of cell cycle]
GO:0071156 [regulation of cell cycle arrest]
GO:0090344 [negative regulation of cell aging]
GO:2000377 [regulation of reactive oxygen species metabolic process]
GO:2000781 [positive regulation of double-strand break repair]
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 763 aa
84.3 kDa 		No 0
FOXM1-003
ENSP00000342307
ENST00000342628
Q08050 [Direct mapping]
Forkhead box protein M1
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   MEMSAT-SVM predicted membrane proteins
   SCAMPI predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Transcription factors
   Helix-turn-helix domains
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000086 [G2/M transition of mitotic cell cycle]
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000278 [mitotic cell cycle]
GO:0000981 [RNA polymerase II transcription factor activity, sequence-specific DNA binding]
GO:0001558 [regulation of cell growth]
GO:0001570 [vasculogenesis]
GO:0001889 [liver development]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006281 [DNA repair]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0006978 [DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator]
GO:0007049 [cell cycle]
GO:0008284 [positive regulation of cell proliferation]
GO:0009653 [anatomical structure morphogenesis]
GO:0019901 [protein kinase binding]
GO:0030154 [cell differentiation]
GO:0032873 [negative regulation of stress-activated MAPK cascade]
GO:0034698 [response to gonadotropin]
GO:0042127 [regulation of cell proliferation]
GO:0043565 [sequence-specific DNA binding]
GO:0044212 [transcription regulatory region DNA binding]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046578 [regulation of Ras protein signal transduction]
GO:0051591 [response to cAMP]
GO:0051726 [regulation of cell cycle]
GO:0071156 [regulation of cell cycle arrest]
GO:0090344 [negative regulation of cell aging]
GO:2000377 [regulation of reactive oxygen species metabolic process]
GO:2000781 [positive regulation of double-strand break repair]
Show all
 801 aa
88.6 kDa 		No 0
FOXM1-009
ENSP00000442309
ENST00000535350
H0YG99 [Direct mapping]
Forkhead box protein M1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000981 [RNA polymerase II transcription factor activity, sequence-specific DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005634 [nucleus]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0009653 [anatomical structure morphogenesis]
GO:0030154 [cell differentiation]
GO:0043565 [sequence-specific DNA binding]
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 206 aa
22.9 kDa 		No 0
FOXM1-201
ENSP00000486536
ENST00000627656
A0A0D9SFF0 [Direct mapping]
Forkhead box protein M1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000981 [RNA polymerase II transcription factor activity, sequence-specific DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005634 [nucleus]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0009653 [anatomical structure morphogenesis]
GO:0030154 [cell differentiation]
GO:0043565 [sequence-specific DNA binding]
Show all
 748 aa
82.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.