Expression of PRR4 in cancer - Summary - The Human Protein Atlas

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PRR4

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TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	PRR4
Gene description	Proline rich 4 (lacrimal)
Protein class	Plasma proteins Predicted intracellular proteins Predicted secreted proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Mixed
HPA (cell line):	Cell line enhanced (HDLM-2)
HPA (normal tissue):	Tissue enriched (salivary gland)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Distinct cytoplasmic expression in salivary gland

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining consistent with RNA expression data.
Reliability score	Supported based on 1 antibody. HPA042133
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Mixed

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA042133

GENE INFORMATION
Gene name	PRR4 (HGNC Symbol)
Synonyms	LPRP, PROL4
Description	Proline rich 4 (lacrimal) (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the proline-rich protein family that lacks a conserved repetitive domain. This protein may play a role in protective functions in the eye. Alternative splicing result in multiple transcript variants. Read-through transcription also exists between this gene and the upstream PRH1 (proline-rich protein HaeIII subfamily 1) gene. [provided by RefSeq, Feb 2011]
Chromosome	12
Cytoband	p13.2
Chromosome location (bp)	10845849 - 11171613
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000111215 (version 83.38)
Entrez gene	11272
UniProt	Q16378 (UniProt - Evidence at protein level)
neXtProt	NX_Q16378
Antibodypedia	PRR4 antibodies

PROTEIN BROWSER

PRR4-001	PRR4-005	PRR4-006	PRR4-017

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PRR4-001 ENSP00000228811 ENST00000228811	Q16378 [Direct mapping] Proline-rich protein 4 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0001895 [retina homeostasis] GO:0005615 [extracellular space] GO:0007601 [visual perception] Show all	134 aa 15.1 kDa	Yes	0
PRR4-005 ENSP00000438046 ENST00000544994	Q16378 [Direct mapping] Proline-rich protein 4 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0001895 [retina homeostasis] GO:0005615 [extracellular space] GO:0007601 [visual perception] Show all	65 aa 7.3 kDa	Yes	0
PRR4-006 ENSP00000443939 ENST00000540107	F5H178 [Direct mapping] Proline-rich protein 4 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		78 aa 8.2 kDa	Yes	0
PRR4-017 ENSP00000481571 ENST00000535024	A0A087WY73 [Direct mapping] Proline-rich protein 4 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		147 aa 16.9 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.