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DUSP16

GENERAL INFORMATION

Gene name

 DUSP16

Gene description

 Dual specificity phosphatase 16

Protein class

 Enzymes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Cell line enhanced (NTERA-2)
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 General cytoplasmic expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Presumed off target binding observed and disregarded.

Reliability score

 Approved based on 1 antibody.
HPA020326
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PROGNOSTIC SUMMARY
Prognostic marker in head and neck cancer (favourable).
Head and neck cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Testis cancer

STAINING SUMMARY
HPA020326

GENE INFORMATION

Gene name

 DUSP16 (HGNC Symbol)

Synonyms

 KIAA1700, MKP-7, MKP7

Description

 Dual specificity phosphatase 16 (HGNC Symbol)

Entrez gene summary

 This gene encodes a mitogen-activated protein kinase phosphatase that is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. The encoded protein specifically regulates the c-Jun amino-terminal kinase (JNK) and extracellular signal-regulated kinase (ERK) pathways.[provided by RefSeq, May 2010]

Chromosome

 12

Cytoband

 p13.2

Chromosome location (bp)

 12474210 - 12562383

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000111266 (version 83.38)

Entrez gene

 80824

UniProt

 Q9BY84 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9BY84

Antibodypedia

 DUSP16 antibodies

PROTEIN BROWSER
DUSP16-001
DUSP16-002
DUSP16-003
DUSP16-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
DUSP16-001
ENSP00000298573
ENST00000298573
Q9BY84 [Direct mapping]
Dual specificity protein phosphatase 16
A0A024RAR2 [Target identity:100%; Query identity:100%]
Dual specificity phosphatase 16, isoform CRA_a
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Enzymes
   ENZYME proteins
   Hydrolases
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
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GO:0000188 [inactivation of MAPK activity]
GO:0004721 [phosphoprotein phosphatase activity]
GO:0004725 [protein tyrosine phosphatase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006470 [protein dephosphorylation]
GO:0008138 [protein tyrosine/serine/threonine phosphatase activity]
GO:0016023 [cytoplasmic membrane-bounded vesicle]
GO:0016311 [dephosphorylation]
GO:0016791 [phosphatase activity]
GO:0017017 [MAP kinase tyrosine/serine/threonine phosphatase activity]
GO:0035335 [peptidyl-tyrosine dephosphorylation]
GO:0043409 [negative regulation of MAPK cascade]
GO:0045204 [MAPK export from nucleus]
GO:0045209 [MAPK phosphatase export from nucleus, leptomycin B sensitive]
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 665 aa
73.1 kDa 		No 0
DUSP16-002
ENSP00000441250
ENST00000541207
Predicted intracellular proteins
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 6 aa
0.7 kDa 		No 0
DUSP16-003
ENSP00000443039
ENST00000539940
F5H5X4 [Direct mapping]
Dual-specificity protein phosphatase 16
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Predicted intracellular proteins
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GO:0006470 [protein dephosphorylation]
GO:0008138 [protein tyrosine/serine/threonine phosphatase activity]
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 25 aa
2.8 kDa 		No 0
DUSP16-201
ENSP00000228862
ENST00000228862
Q9BY84 [Direct mapping]
Dual specificity protein phosphatase 16
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Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Show all
GO:0000188 [inactivation of MAPK activity]
GO:0004721 [phosphoprotein phosphatase activity]
GO:0004725 [protein tyrosine phosphatase activity]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006470 [protein dephosphorylation]
GO:0008138 [protein tyrosine/serine/threonine phosphatase activity]
GO:0016023 [cytoplasmic membrane-bounded vesicle]
GO:0016311 [dephosphorylation]
GO:0017017 [MAP kinase tyrosine/serine/threonine phosphatase activity]
GO:0035335 [peptidyl-tyrosine dephosphorylation]
GO:0045204 [MAPK export from nucleus]
GO:0045209 [MAPK phosphatase export from nucleus, leptomycin B sensitive]
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 143 aa
16.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.