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CREBL2

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GENERAL INFORMATION

Gene name

 CREBL2

Gene description

 CAMP responsive element binding protein-like 2

Protein class

 Predicted intracellular proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Mainly localized to the mitochondria. In addition localized to the cytosol & nucleoplasm.

RNA cell category

 Expressed in all

Protein evidence

 Evidence at protein level

Main location

 Localized to the Mitochondria (approved)

Additional location

 In addition localized to the Nucleoplasm (approved), Cytosol (approved)

DATA RELIABILITY

Reliability score

 Approved based on 1 antibody.
HPA043738
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Mainly localized to the mitochondria. In addition localized to the cytosol & nucleoplasm.

Main location

 Mitochondria (approved)

Additional location

 Nucleoplasm (approved), Cytosol (approved)

 

 

 
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Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA043738 A-431 Mitochondria
HPA043738 U-2 OS Mitochondria
HPA043738 U-251 MG Nucleoplasm
Cytosol

GENE INFORMATION

Gene name

 CREBL2

Synonyms

Description

 CAMP responsive element binding protein-like 2 (HGNC Symbol)

Entrez gene summary

 cAMP response element (CRE)-binding protein-like-2 (CREBL2) was identified in a search to find genes in a commonly deleted region on chromosome 12p13 flanked by ETV6 and CDKN1B genes, frequently associated with hematopoietic malignancies, as well as breast, non-small-cell lung and ovarian cancers. CREBL2 shares a 41% identity with CRE-binding protein (CREB) over a 48-base long region which encodes the bZip domain of CREB. The bZip domain consists of about 30 amino acids rich in basic residues involved in DNA binding, followed by a leucine zipper motif involved in protein dimerization. This suggests that CREBL2 encodes a protein with DNA binding capabilities. The occurance of CREBL2 deletion in malignancy suggests that CREBL2 may act as a tumor suppressor gene. [provided by RefSeq, Jul 2008]

Chromosome

 12

Cytoband

 p13.1

Chromosome location (bp)

 12611827 - 12645108

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000111269 (version 83.38)

Entrez gene

 1389

UniProt

 O60519 (UniProt - Evidence at protein level)

neXtProt

 NX_O60519

Antibodypedia

 CREBL2 antibodies

PROTEIN BROWSER
CREBL2-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CREBL2-001
ENSP00000228865
ENST00000228865
O60519 [Direct mapping]
cAMP-responsive element-binding protein-like 2
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Predicted intracellular proteins
Transcription factors
   Basic domains
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GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005634 [nucleus]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0007049 [cell cycle]
GO:0007165 [signal transduction]
GO:0030154 [cell differentiation]
GO:0033138 [positive regulation of peptidyl-serine phosphorylation]
GO:0043565 [sequence-specific DNA binding]
GO:0045600 [positive regulation of fat cell differentiation]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0046326 [positive regulation of glucose import]
GO:0046889 [positive regulation of lipid biosynthetic process]
GO:0050821 [protein stabilization]
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 120 aa
13.8 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.