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ALDH2

GENERAL INFORMATION

Gene name

 ALDH2

Gene description

 Aldehyde dehydrogenase 2 family (mitochondrial)

Protein class

 Cancer-related genes
Enzymes
FDA approved drug targets
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Cell line enhanced (SK-BR-3)
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in several tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
HPA051065
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (favourable), renal cancer (favourable), endometrial cancer (favourable) and urothelial cancer (unfavourable).
Liver cancer p<0.001
Renal cancer p<0.001
Endometrial cancer p<0.001
Urothelial cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA051065

GENE INFORMATION

Gene name

 ALDH2

Synonyms

Description

 Aldehyde dehydrogenase 2 family (mitochondrial) (HGNC Symbol)

Entrez gene summary

 This protein belongs to the aldehyde dehydrogenase family of proteins. Aldehyde dehydrogenase is the second enzyme of the major oxidative pathway of alcohol metabolism. Two major liver isoforms of aldehyde dehydrogenase, cytosolic and mitochondrial, can be distinguished by their electrophoretic mobilities, kinetic properties, and subcellular localizations. Most Caucasians have two major isozymes, while approximately 50% of Orientals have the cytosolic isozyme but not the mitochondrial isozyme. A remarkably higher frequency of acute alcohol intoxication among Orientals than among Caucasians could be related to the absence of a catalytically active form of the mitochondrial isozyme. The increased exposure to acetaldehyde in individuals with the catalytically inactive form may also confer greater susceptibility to many types of cancer. This gene encodes a mitochondrial isoform, which has a low Km for acetaldehydes, and is localized in mitochondrial matrix. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Mar 2011]

Chromosome

 12

Cytoband

 q24.12

Chromosome location (bp)

 111766887 - 111817529

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000111275 (version 83.38)

Entrez gene

 217

UniProt

 P05091 (UniProt - Evidence at protein level)

neXtProt

 NX_P05091

Antibodypedia

 ALDH2 antibodies

PROTEIN BROWSER
ALDH2-001
ALDH2-003

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ALDH2-001
ENSP00000261733
ENST00000261733
P05091 [Direct mapping]
Aldehyde dehydrogenase, mitochondrial
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Enzymes
   ENZYME proteins
   Oxidoreductases
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   Phobius predicted secreted proteins
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0004029 [aldehyde dehydrogenase (NAD) activity]
GO:0004030 [aldehyde dehydrogenase [NAD(P)+] activity]
GO:0005759 [mitochondrial matrix]
GO:0005975 [carbohydrate metabolic process]
GO:0006066 [alcohol metabolic process]
GO:0006068 [ethanol catabolic process]
GO:0006069 [ethanol oxidation]
GO:0006805 [xenobiotic metabolic process]
GO:0007268 [synaptic transmission]
GO:0008152 [metabolic process]
GO:0009055 [electron carrier activity]
GO:0016491 [oxidoreductase activity]
GO:0042136 [neurotransmitter biosynthetic process]
GO:0044281 [small molecule metabolic process]
GO:0055114 [oxidation-reduction process]
GO:0070062 [extracellular exosome]
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 517 aa
56.4 kDa 		No 0
ALDH2-003
ENSP00000403349
ENST00000416293
P05091 [Direct mapping]
Aldehyde dehydrogenase, mitochondrial
Show all
Enzymes
   ENZYME proteins
   Oxidoreductases
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   Phobius predicted secreted proteins
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
FDA approved drug targets
   Small molecule drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004029 [aldehyde dehydrogenase (NAD) activity]
GO:0004030 [aldehyde dehydrogenase [NAD(P)+] activity]
GO:0005759 [mitochondrial matrix]
GO:0005975 [carbohydrate metabolic process]
GO:0006066 [alcohol metabolic process]
GO:0006068 [ethanol catabolic process]
GO:0006069 [ethanol oxidation]
GO:0006805 [xenobiotic metabolic process]
GO:0007268 [synaptic transmission]
GO:0008152 [metabolic process]
GO:0009055 [electron carrier activity]
GO:0016491 [oxidoreductase activity]
GO:0042136 [neurotransmitter biosynthetic process]
GO:0044281 [small molecule metabolic process]
GO:0055114 [oxidation-reduction process]
GO:0070062 [extracellular exosome]
Show all
 470 aa
51 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.