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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
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CDKN1B
  • TISSUE

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PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

GENERAL INFORMATION

Gene name

CDKN1B

Gene description

Cyclin-dependent kinase inhibitor 1B (p27, Kip1)

Protein class

Cancer-related genes
Disease related genes
Predicted intracellular proteins

Predicted localization

Intracellular

Number of transcripts

3
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):Expressed in all
HPA (cell line):Mixed
HPA (normal tissue):Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic and nuclear expression in most tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

Antibody staining mainly consistent with RNA expression data.

Reliability score

Approved based on 2 antibodies.
CAB003691 , CAB021888
SHOW MORE

PROGNOSTIC SUMMARY

Prognostic marker in liver cancer (unfavourable), colorectal cancer (favourable) and renal cancer (unfavourable).
Liver cancer p<0.001
Colorectal cancer p<0.001
Renal cancer p<0.001
Show all

RNA EXPRESSION OVERVIEW

TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY

CAB003691
CAB021888

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Breast, prostate, ovarian, skin cancer and malignant gliomas and lymphomas showed moderate to strong distinct nuclear positivity. Remaining cancer tissues were weakly stained or negative.

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

A majority of gliomas showed moderate cytoplasmic and nuclear staining. Several melanomas showed moderate cytoplasmic staining while remaining cancer tissues were weakly stained or negative.

GENE INFORMATION

Gene name

CDKN1B (HGNC Symbol)

Synonyms

KIP1, P27KIP1

Description

Cyclin-dependent kinase inhibitor 1B (p27, Kip1) (HGNC Symbol)

Entrez gene summary

This gene encodes a cyclin-dependent kinase inhibitor, which shares a limited similarity with CDK inhibitor CDKN1A/p21. The encoded protein binds to and prevents the activation of cyclin E-CDK2 or cyclin D-CDK4 complexes, and thus controls the cell cycle progression at G1. The degradation of this protein, which is triggered by its CDK dependent phosphorylation and subsequent ubiquitination by SCF complexes, is required for the cellular transition from quiescence to the proliferative state. Mutations in this gene are associated with multiple endocrine neoplasia type IV (MEN4). [provided by RefSeq, Apr 2014]

Chromosome

12

Cytoband

p13.1

Chromosome location (bp)

12715058 - 12722371

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000111276 (version 83.38)

Entrez gene

1027

UniProt

P46527 (UniProt - Evidence at protein level)

neXtProt

NX_P46527

Antibodypedia

CDKN1B antibodies

PROTEIN BROWSER

CDKN1B-001
CDKN1B-002
CDKN1B-003

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CDKN1B-001
ENSP00000228872
ENST00000228872
P46527 [Direct mapping]
Cyclin-dependent kinase inhibitor 1B
Q6I9V6 [Target identity:100%; Query identity:100%]
CDKN1B protein; Cyclin-dependent kinase inhibitor 1B; Cyclin-dependent kinase inhibitor 1B (P27, Kip1), isoform CRA_a; cDNA, FLJ92816, Homo sapiens cyclin-dependent kinase inhibitor 1B (p27, Kip1)(CDKN1B), mRNA
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Germline Mutations
   COSMIC Frameshift Mutations
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000079 [regulation of cyclin-dependent protein serine/threonine kinase activity]
GO:0000082 [G1/S transition of mitotic cell cycle]
GO:0000278 [mitotic cell cycle]
GO:0001666 [response to hypoxia]
GO:0004861 [cyclin-dependent protein serine/threonine kinase inhibitor activity]
GO:0005072 [transforming growth factor beta receptor, cytoplasmic mediator activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005768 [endosome]
GO:0005829 [cytosol]
GO:0006813 [potassium ion transport]
GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0006977 [DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest]
GO:0007050 [cell cycle arrest]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007219 [Notch signaling pathway]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007605 [sensory perception of sound]
GO:0008219 [cell death]
GO:0008284 [positive regulation of cell proliferation]
GO:0008285 [negative regulation of cell proliferation]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0008656 [cysteine-type endopeptidase activator activity involved in apoptotic process]
GO:0009749 [response to glucose]
GO:0010942 [positive regulation of cell death]
GO:0014070 [response to organic cyclic compound]
GO:0019903 [protein phosphatase binding]
GO:0030308 [negative regulation of cell growth]
GO:0030544 [Hsp70 protein binding]
GO:0031116 [positive regulation of microtubule polymerization]
GO:0031464 [Cul4A-RING E3 ubiquitin ligase complex]
GO:0032355 [response to estradiol]
GO:0032403 [protein complex binding]
GO:0033673 [negative regulation of kinase activity]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0042326 [negative regulation of phosphorylation]
GO:0042493 [response to drug]
GO:0043066 [negative regulation of apoptotic process]
GO:0043200 [response to amino acid]
GO:0043234 [protein complex]
GO:0043434 [response to peptide hormone]
GO:0045087 [innate immune response]
GO:0045732 [positive regulation of protein catabolic process]
GO:0045736 [negative regulation of cyclin-dependent protein serine/threonine kinase activity]
GO:0045737 [positive regulation of cyclin-dependent protein serine/threonine kinase activity]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0045930 [negative regulation of mitotic cell cycle]
GO:0046686 [response to cadmium ion]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0048015 [phosphatidylinositol-mediated signaling]
GO:0048102 [autophagic cell death]
GO:0048839 [inner ear development]
GO:0050680 [negative regulation of epithelial cell proliferation]
GO:0051087 [chaperone binding]
GO:0051271 [negative regulation of cellular component movement]
GO:0060770 [negative regulation of epithelial cell proliferation involved in prostate gland development]
GO:0071236 [cellular response to antibiotic]
GO:0071285 [cellular response to lithium ion]
GO:0071407 [cellular response to organic cyclic compound]
GO:0071850 [mitotic cell cycle arrest]
Show all
198 aa
22.1 kDa
No 0
CDKN1B-002
ENSP00000407597
ENST00000442489
H7C2T1 [Direct mapping]
Cyclin-dependent kinase inhibitor 1B
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Germline Mutations
   COSMIC Frameshift Mutations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004861 [cyclin-dependent protein serine/threonine kinase inhibitor activity]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0007050 [cell cycle arrest]
GO:0042127 [regulation of cell proliferation]
GO:0071901 [negative regulation of protein serine/threonine kinase activity]
Show all
104 aa
11.9 kDa
No 0
CDKN1B-003
ENSP00000379629
ENST00000396340
E7ES52 [Direct mapping]
Cyclin-dependent kinase inhibitor 1B
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutated cancer genes
   Mutational cancer driver genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Germline Mutations
   COSMIC Frameshift Mutations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004861 [cyclin-dependent protein serine/threonine kinase inhibitor activity]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0007050 [cell cycle arrest]
GO:0042127 [regulation of cell proliferation]
GO:0071901 [negative regulation of protein serine/threonine kinase activity]
Show all
205 aa
23.2 kDa
No 0

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