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Breast, prostate, ovarian, skin cancer and malignant gliomas and lymphomas showed moderate to strong distinct nuclear positivity. Remaining cancer tissues were weakly stained or negative.
A majority of gliomas showed moderate cytoplasmic and nuclear staining. Several melanomas showed moderate cytoplasmic staining while remaining cancer tissues were weakly stained or negative.
This gene encodes a cyclin-dependent kinase inhibitor, which shares a limited similarity with CDK inhibitor CDKN1A/p21. The encoded protein binds to and prevents the activation of cyclin E-CDK2 or cyclin D-CDK4 complexes, and thus controls the cell cycle progression at G1. The degradation of this protein, which is triggered by its CDK dependent phosphorylation and subsequent ubiquitination by SCF complexes, is required for the cellular transition from quiescence to the proliferative state. Mutations in this gene are associated with multiple endocrine neoplasia type IV (MEN4). [provided by RefSeq, Apr 2014]
Predicted intracellular proteins Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Germline Mutations COSMIC Frameshift Mutations Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000079 [regulation of cyclin-dependent protein serine/threonine kinase activity] GO:0000082 [G1/S transition of mitotic cell cycle] GO:0000278 [mitotic cell cycle] GO:0001666 [response to hypoxia] GO:0004861 [cyclin-dependent protein serine/threonine kinase inhibitor activity] GO:0005072 [transforming growth factor beta receptor, cytoplasmic mediator activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005768 [endosome] GO:0005829 [cytosol] GO:0006813 [potassium ion transport] GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process] GO:0006977 [DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest] GO:0007050 [cell cycle arrest] GO:0007173 [epidermal growth factor receptor signaling pathway] GO:0007219 [Notch signaling pathway] GO:0007264 [small GTPase mediated signal transduction] GO:0007605 [sensory perception of sound] GO:0008219 [cell death] GO:0008284 [positive regulation of cell proliferation] GO:0008285 [negative regulation of cell proliferation] GO:0008543 [fibroblast growth factor receptor signaling pathway] GO:0008656 [cysteine-type endopeptidase activator activity involved in apoptotic process] GO:0009749 [response to glucose] GO:0010942 [positive regulation of cell death] GO:0014070 [response to organic cyclic compound] GO:0019903 [protein phosphatase binding] GO:0030308 [negative regulation of cell growth] GO:0030544 [Hsp70 protein binding] GO:0031116 [positive regulation of microtubule polymerization] GO:0031464 [Cul4A-RING E3 ubiquitin ligase complex] GO:0032355 [response to estradiol] GO:0032403 [protein complex binding] GO:0033673 [negative regulation of kinase activity] GO:0038095 [Fc-epsilon receptor signaling pathway] GO:0042326 [negative regulation of phosphorylation] GO:0042493 [response to drug] GO:0043066 [negative regulation of apoptotic process] GO:0043200 [response to amino acid] GO:0043234 [protein complex] GO:0043434 [response to peptide hormone] GO:0045087 [innate immune response] GO:0045732 [positive regulation of protein catabolic process] GO:0045736 [negative regulation of cyclin-dependent protein serine/threonine kinase activity] GO:0045737 [positive regulation of cyclin-dependent protein serine/threonine kinase activity] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0045930 [negative regulation of mitotic cell cycle] GO:0046686 [response to cadmium ion] GO:0048011 [neurotrophin TRK receptor signaling pathway] GO:0048015 [phosphatidylinositol-mediated signaling] GO:0048102 [autophagic cell death] GO:0048839 [inner ear development] GO:0050680 [negative regulation of epithelial cell proliferation] GO:0051087 [chaperone binding] GO:0051271 [negative regulation of cellular component movement] GO:0060770 [negative regulation of epithelial cell proliferation involved in prostate gland development] GO:0071236 [cellular response to antibiotic] GO:0071285 [cellular response to lithium ion] GO:0071407 [cellular response to organic cyclic compound] GO:0071850 [mitotic cell cycle arrest]
Predicted intracellular proteins Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Germline Mutations COSMIC Frameshift Mutations Protein evidence (Ezkurdia et al 2014)
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GO:0004861 [cyclin-dependent protein serine/threonine kinase inhibitor activity] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0007050 [cell cycle arrest] GO:0042127 [regulation of cell proliferation] GO:0071901 [negative regulation of protein serine/threonine kinase activity]
Predicted intracellular proteins Cancer-related genes Mutated cancer genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Germline Mutations COSMIC Frameshift Mutations Protein evidence (Ezkurdia et al 2014)
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GO:0004861 [cyclin-dependent protein serine/threonine kinase inhibitor activity] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0007050 [cell cycle arrest] GO:0042127 [regulation of cell proliferation] GO:0071901 [negative regulation of protein serine/threonine kinase activity]