Expression of LTBR in cancer - Summary - The Human Protein Atlas

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LTBR

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	LTBR
Gene description	Lymphotoxin beta receptor (TNFR superfamily, member 3)
Protein class	Cancer-related genes Plasma proteins Predicted intracellular proteins Predicted membrane proteins Predicted secreted proteins
Predicted localization	Intracellular,Membrane,Secreted
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Mixed
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression of immune cells in several tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Staining of some immune cells are not annotated, view images.
Reliability score	Uncertain based on 1 antibody. CAB026202
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable) and renal cancer (unfavourable).
Liver cancer p<0.001 Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

CAB026202

GENE INFORMATION
Gene name	LTBR (HGNC Symbol)
Synonyms	D12S370, TNF-R-III, TNFCR, TNFR-RP, TNFR2-RP, TNFRSF3
Description	Lymphotoxin beta receptor (TNFR superfamily, member 3) (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the tumor necrosis factor receptor superfamily. The major ligands of this receptor include lymphotoxin alpha/beta and tumor necrosis factor ligand superfamily member 14. The encoded protein plays a role in signalling during the development of lymphoid and other organs, lipid metabolism, immune response, and programmed cell death. Activity of this receptor has also been linked to carcinogenesis. Alternatively spliced transcript variants encoding multiple isoforms have been observed. [provided by RefSeq, Aug 2012]
Chromosome	12
Cytoband	p13.31
Chromosome location (bp)	6375045 - 6391571
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000111321 (version 83.38)
Entrez gene	4055
UniProt	P36941 (UniProt - Evidence at protein level)
neXtProt	NX_P36941
Antibodypedia	LTBR antibodies

PROTEIN BROWSER

LTBR-001	LTBR-003	LTBR-010	LTBR-012	LTBR-014

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
LTBR-001 ENSP00000228918 ENST00000228918	P36941 [Direct mapping] Tumor necrosis factor receptor superfamily member 3 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Ezkurdia et al 2014) Show all	GO:0005031 [tumor necrosis factor-activated receptor activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006915 [apoptotic process] GO:0006954 [inflammatory response] GO:0006955 [immune response] GO:0007165 [signal transduction] GO:0007275 [multicellular organismal development] GO:0016032 [viral process] GO:0031625 [ubiquitin protein ligase binding] GO:0032496 [response to lipopolysaccharide] GO:0033209 [tumor necrosis factor-mediated signaling pathway] GO:0042127 [regulation of cell proliferation] GO:0042802 [identical protein binding] GO:0043011 [myeloid dendritic cell differentiation] GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling] GO:0046330 [positive regulation of JNK cascade] GO:0071260 [cellular response to mechanical stimulus] GO:2001238 [positive regulation of extrinsic apoptotic signaling pathway] Show all	435 aa 46.7 kDa	Yes	1
LTBR-003 ENSP00000440875 ENST00000539925	P36941 [Direct mapping] Tumor necrosis factor receptor superfamily member 3 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Ezkurdia et al 2014) Show all	GO:0005031 [tumor necrosis factor-activated receptor activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006915 [apoptotic process] GO:0006954 [inflammatory response] GO:0006955 [immune response] GO:0007165 [signal transduction] GO:0007275 [multicellular organismal development] GO:0016032 [viral process] GO:0031625 [ubiquitin protein ligase binding] GO:0032496 [response to lipopolysaccharide] GO:0033209 [tumor necrosis factor-mediated signaling pathway] GO:0042127 [regulation of cell proliferation] GO:0042802 [identical protein binding] GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling] GO:0046330 [positive regulation of JNK cascade] GO:0071260 [cellular response to mechanical stimulus] GO:2001238 [positive regulation of extrinsic apoptotic signaling pathway] Show all	416 aa 44.8 kDa	No	1
LTBR-010 ENSP00000438605 ENST00000541102	F5H2E7 [Direct mapping] Tumor necrosis factor receptor superfamily member 3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	292 aa 30.8 kDa	No	0
LTBR-012 ENSP00000438955 ENST00000543190	F5H1S5 [Direct mapping] Tumor necrosis factor receptor superfamily member 3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		74 aa 8.3 kDa	No	0
LTBR-014 ENSP00000437647 ENST00000536876	F5H6F8 [Direct mapping] Tumor necrosis factor receptor superfamily member 3 Show all	THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	218 aa 23.8 kDa	Yes	0

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