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OAS3

GENERAL INFORMATION

Gene name

 OAS3

Gene description

 2'-5'-oligoadenylate synthetase 3, 100kDa

Protein class

 Enzymes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Cell line enhanced (BJ hTERT+ SV40 Large T+, BJ hTERT+ SV40 Large T+ RasG12V)
HPA (normal tissue):Mixed

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data.

Reliability score

 Uncertain based on 2 antibodies.
HPA041253 , HPA041372
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable).
Renal cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA041253
HPA041372

GENE INFORMATION

Gene name

 OAS3

Synonyms

Description

 2'-5'-oligoadenylate synthetase 3, 100kDa (HGNC Symbol)

Entrez gene summary

 This gene encodes an enzyme included in the 2', 5' oligoadenylate synthase family. This enzyme is induced by interferons and catalyzes the 2', 5' oligomers of adenosine in order to bind and activate RNase L. This enzyme family plays a significant role in the inhibition of cellular protein synthesis and viral infection resistance. [provided by RefSeq, Jul 2008]

Chromosome

 12

Cytoband

 q24.13

Chromosome location (bp)

 112938352 - 112973249

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000111331 (version 83.38)

Entrez gene

 4940

UniProt

 Q9Y6K5 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9Y6K5

Antibodypedia

 OAS3 antibodies

PROTEIN BROWSER
OAS3-001
OAS3-002
OAS3-003
OAS3-006

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
OAS3-001
ENSP00000228928
ENST00000228928
Q9Y6K5 [Direct mapping]
2'-5'-oligoadenylate synthase 3
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Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0001730 [2'-5'-oligoadenylate synthetase activity]
GO:0003723 [RNA binding]
GO:0003725 [double-stranded RNA binding]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005615 [extracellular space]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006139 [nucleobase-containing compound metabolic process]
GO:0006955 [immune response]
GO:0009615 [response to virus]
GO:0016740 [transferase activity]
GO:0016779 [nucleotidyltransferase activity]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0045071 [negative regulation of viral genome replication]
GO:0046872 [metal ion binding]
GO:0051607 [defense response to virus]
GO:0060333 [interferon-gamma-mediated signaling pathway]
GO:0060337 [type I interferon signaling pathway]
GO:0060700 [regulation of ribonuclease activity]
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 1087 aa
121.2 kDa 		No 0
OAS3-002
ENSP00000449299
ENST00000551007
F8VWK9 [Direct mapping]
2'-5'-oligoadenylate synthase 3
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0003723 [RNA binding]
GO:0003725 [double-stranded RNA binding]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0006955 [immune response]
GO:0008152 [metabolic process]
GO:0016740 [transferase activity]
GO:0051607 [defense response to virus]
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 177 aa
19.5 kDa 		No 0
OAS3-003
ENSP00000448388
ENST00000548514
F8VS35 [Direct mapping]
2'-5'-oligoadenylate synthase 3
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003723 [RNA binding]
GO:0003725 [double-stranded RNA binding]
GO:0005524 [ATP binding]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0006955 [immune response]
GO:0008152 [metabolic process]
GO:0016740 [transferase activity]
GO:0051607 [defense response to virus]
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 223 aa
24.6 kDa 		No 0
OAS3-006
ENSP00000447323
ENST00000546973
H0YHL3 [Direct mapping]
2'-5'-oligoadenylate synthase 3
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003725 [double-stranded RNA binding]
GO:0051607 [defense response to virus]
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 166 aa
18.8 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.