Tissue expression of ART4 - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	ART4
Gene description	ADP-ribosyltransferase 4 (Dombrock blood group)
Protein class	Blood group antigen proteins CD markers Enzymes Predicted membrane proteins Predicted secreted proteins
Predicted localization	Membrane,Secreted
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enhanced (liver, spleen)
GTEx:	Tissue enhanced (liver, spleen)
FANTOM5:	Tissue enhanced (liver)

Protein evidence

Evidence at protein level

DATA RELIABILITY
Reliability score	Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

Bronchus

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

Skin

N/A

Skin

N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (liver, spleen)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (liver, spleen)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (liver)

GENE INFORMATION
Gene name	ART4 (HGNC Symbol)
Synonyms	CD297, DO, DOK1
Description	ADP-ribosyltransferase 4 (Dombrock blood group) (HGNC Symbol)
Entrez gene summary	This gene encodes a protein that contains a mono-ADP-ribosylation (ART) motif. It is a member of the ADP-ribosyltransferase gene family but enzymatic activity has not been demonstrated experimentally. Antigens of the Dombrock blood group system are located on the gene product, which is glycosylphosphatidylinosotol-anchored to the erythrocyte membrane. Allelic variants, some of which lead to adverse transfusion reactions, are known. [provided by RefSeq, Jul 2008]
Chromosome	12
Cytoband	p12.3
Chromosome location (bp)	14825569 - 14843495
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000111339 (version 83.38)
Entrez gene	420
UniProt	Q93070 (UniProt - Evidence at transcript level)
neXtProt	NX_Q93070
Antibodypedia	ART4 antibodies

PROTEIN BROWSER

ART4-001	ART4-002	ART4-003	ART4-004

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ART4-001 ENSP00000228936 ENST00000228936	Q93070 [Direct mapping] Ecto-ADP-ribosyltransferase 4 Show all	Enzymes ENZYME proteins Transferases CD markers Blood group antigen proteins Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003956 [NAD(P)+-protein-arginine ADP-ribosyltransferase activity] GO:0005886 [plasma membrane] GO:0006471 [protein ADP-ribosylation] GO:0006525 [arginine metabolic process] GO:0016020 [membrane] GO:0031225 [anchored component of membrane] Show all	314 aa 35.9 kDa	Yes	1
ART4-002 ENSP00000405689 ENST00000420600	H7C2G2 [Direct mapping] NAD(P)(+)--arginine ADP-ribosyltransferase Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003956 [NAD(P)+-protein-arginine ADP-ribosyltransferase activity] GO:0006471 [protein ADP-ribosylation] Show all	273 aa 31.5 kDa	Yes	0
ART4-003 ENSP00000412735 ENST00000430129	Q3KZ30 [Direct mapping] Dombrock blood group carrier molecule splice variant II; Ecto-ADP-ribosyltransferase 4 Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003956 [NAD(P)+-protein-arginine ADP-ribosyltransferase activity] GO:0006471 [protein ADP-ribosylation] Show all	65 aa 7.1 kDa	Yes	0
ART4-004 ENSP00000442877 ENST00000544616	Q3KZ29 [Direct mapping] Dombrock blood group carrier molecule splice variant III; Ecto-ADP-ribosyltransferase 4 Show all	MEMSAT3 predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		41 aa 4.4 kDa	Yes	0