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RASAL1

GENERAL INFORMATION

Gene name

 RASAL1

Gene description

 RAS protein activator like 1 (GAP1 like)

Protein class

 Plasma proteins
Predicted intracellular proteins
RAS pathway related proteins

Predicted localization

 Intracellular

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enriched (parathyroid gland)
GTEx:Mixed
FANTOM5:Tissue enhanced (salivary gland)

Protein evidence

 Evidence at protein level

Protein expression

 Mainly cytoplasmic expression in most tissues.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data. Pending external verification.

Reliability score

 Uncertain based on 1 antibody.
HPA041650
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Salivary gland

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (parathyroid gland)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (salivary gland)

GENE INFORMATION

Gene name

 RASAL1 (HGNC Symbol)

Synonyms

 RASAL

Description

 RAS protein activator like 1 (GAP1 like) (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is member of the GAP1 family of GTPase-activating proteins. These proteins stimulate the GTPase activity of normal RAS p21 but not its oncogenic counterpart. Acting as a suppressor of RAS function, the protein enhances the weak intrinsic GTPase activity of RAS proteins resulting in the inactive GDP-bound form of RAS, thereby allowing control of cellular proliferation and differentiation. This particular family member contains domains which are characteristic of the GAP1 subfamily of RasGAP proteins but, in contrast to the other GAP1 family members, this protein is strongly and selectively expressed in endocrine tissues. Alternatively spliced transcript variants that encode different isoforms have been described [provided by RefSeq, Jul 2010]

Chromosome

 12

Cytoband

 q24.13

Chromosome location (bp)

 113098819 - 113136239

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000111344 (version 83.38)

Entrez gene

 8437

UniProt

 O95294 (UniProt - Evidence at protein level)

neXtProt

 NX_O95294

Antibodypedia

 RASAL1 antibodies

PROTEIN BROWSER
RASAL1-001
RASAL1-004
RASAL1-007
RASAL1-008

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
RASAL1-001
ENSP00000261729
ENST00000261729
O95294 [Direct mapping]
RasGAP-activating-like protein 1
Show all
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
RAS pathway related proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000165 [MAPK cascade]
GO:0000186 [activation of MAPKK activity]
GO:0005096 [GTPase activator activity]
GO:0005515 [protein binding]
GO:0005543 [phospholipid binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0007165 [signal transduction]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007265 [Ras protein signal transduction]
GO:0007411 [axon guidance]
GO:0008286 [insulin receptor signaling pathway]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0031235 [intrinsic component of the cytoplasmic side of the plasma membrane]
GO:0035556 [intracellular signal transduction]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0043087 [regulation of GTPase activity]
GO:0043547 [positive regulation of GTPase activity]
GO:0045087 [innate immune response]
GO:0046580 [negative regulation of Ras protein signal transduction]
GO:0046872 [metal ion binding]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:1903861 [positive regulation of dendrite extension]
Show all
 804 aa
90 kDa 		No 0
RASAL1-004
ENSP00000395920
ENST00000446861
O95294 [Direct mapping]
RasGAP-activating-like protein 1
Show all
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
RAS pathway related proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000165 [MAPK cascade]
GO:0000186 [activation of MAPKK activity]
GO:0005096 [GTPase activator activity]
GO:0005515 [protein binding]
GO:0005543 [phospholipid binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0007165 [signal transduction]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007265 [Ras protein signal transduction]
GO:0007411 [axon guidance]
GO:0008286 [insulin receptor signaling pathway]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0031235 [intrinsic component of the cytoplasmic side of the plasma membrane]
GO:0035556 [intracellular signal transduction]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0043087 [regulation of GTPase activity]
GO:0043547 [positive regulation of GTPase activity]
GO:0045087 [innate immune response]
GO:0046580 [negative regulation of Ras protein signal transduction]
GO:0046872 [metal ion binding]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:1903861 [positive regulation of dendrite extension]
Show all
 776 aa
86.8 kDa 		No 0
RASAL1-007
ENSP00000448510
ENST00000548055
O95294 [Direct mapping]
RasGAP-activating-like protein 1
Show all
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
RAS pathway related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000165 [MAPK cascade]
GO:0000186 [activation of MAPKK activity]
GO:0005096 [GTPase activator activity]
GO:0005515 [protein binding]
GO:0005543 [phospholipid binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0007165 [signal transduction]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007265 [Ras protein signal transduction]
GO:0007411 [axon guidance]
GO:0008286 [insulin receptor signaling pathway]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0031235 [intrinsic component of the cytoplasmic side of the plasma membrane]
GO:0035556 [intracellular signal transduction]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0043087 [regulation of GTPase activity]
GO:0043547 [positive regulation of GTPase activity]
GO:0045087 [innate immune response]
GO:0046580 [negative regulation of Ras protein signal transduction]
GO:0046872 [metal ion binding]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:1903861 [positive regulation of dendrite extension]
Show all
 805 aa
90.1 kDa 		No 0
RASAL1-008
ENSP00000450244
ENST00000546530
O95294 [Direct mapping]
RasGAP-activating-like protein 1
Show all
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
RAS pathway related proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000165 [MAPK cascade]
GO:0000186 [activation of MAPKK activity]
GO:0005096 [GTPase activator activity]
GO:0005515 [protein binding]
GO:0005543 [phospholipid binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0007165 [signal transduction]
GO:0007173 [epidermal growth factor receptor signaling pathway]
GO:0007264 [small GTPase mediated signal transduction]
GO:0007265 [Ras protein signal transduction]
GO:0007411 [axon guidance]
GO:0008286 [insulin receptor signaling pathway]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0031235 [intrinsic component of the cytoplasmic side of the plasma membrane]
GO:0035556 [intracellular signal transduction]
GO:0038095 [Fc-epsilon receptor signaling pathway]
GO:0043087 [regulation of GTPase activity]
GO:0043547 [positive regulation of GTPase activity]
GO:0045087 [innate immune response]
GO:0046580 [negative regulation of Ras protein signal transduction]
GO:0046872 [metal ion binding]
GO:0048010 [vascular endothelial growth factor receptor signaling pathway]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:1903861 [positive regulation of dendrite extension]
Show all
 806 aa
90.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.