Expression of C12orf49 in cancer - Summary - The Human Protein Atlas

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C12orf49

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	C12orf49
Gene description	Chromosome 12 open reading frame 49
Protein class	Predicted intracellular proteins Predicted secreted proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Tissue enhanced (thyroid gland)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in several different tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Pending external verification.
Reliability score	Uncertain based on 1 antibody. HPA026905
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable) and liver cancer (unfavourable).
Renal cancer p<0.001 Liver cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA026905

GENE INFORMATION
Gene name	C12orf49 (HGNC Symbol)
Synonyms	FLJ21415
Description	Chromosome 12 open reading frame 49 (HGNC Symbol)
Entrez gene summary
Chromosome	12
Cytoband	q24.22
Chromosome location (bp)	116710185 - 116738070
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000111412 (version 83.38)
Entrez gene	79794
UniProt	Q9H741 (UniProt - Evidence at protein level)
neXtProt	NX_Q9H741
Antibodypedia	C12orf49 antibodies

PROTEIN BROWSER

C12orf49-001	C12orf49-003	C12orf49-004

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
C12orf49-001 ENSP00000261318 ENST00000261318	Q9H741 [Direct mapping] UPF0454 protein C12orf49 A0A024RBQ8 [Target identity:100%; Query identity:100%] Chromosome 12 open reading frame 49, isoform CRA_a Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005576 [extracellular region] Show all	205 aa 23.6 kDa	Yes	0
C12orf49-003 ENSP00000449151 ENST00000548356	F8VVN2 [Direct mapping] UPF0454 protein C12orf49 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		46 aa 5.3 kDa	No	0
C12orf49-004 ENSP00000447722 ENST00000547606	H0YHS8 [Direct mapping] UPF0454 protein C12orf49 Show all	SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		43 aa 4.8 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.