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FZD10

GENERAL INFORMATION

Gene name

 FZD10

Gene description

 Frizzled class receptor 10

Protein class

 CD markers
G-protein coupled receptors
Predicted intracellular proteins
Predicted membrane proteins

Predicted localization

 Intracellular,Membrane

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Mixed
HPA (cell line):Group enriched (AF22, BEWO, hTCEpi, RPTEC TERT1, RT4)
HPA (normal tissue):Tissue enhanced (cervix, uterine, esophagus)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Estimation of protein expression could not be performed. View primary data.

ANTIBODY IHC RELIABILITY

Data reliability
description

 RNA-based expert annotation gave inconclusive results. Pending external verification.

Reliability score

 Uncertain based on 2 antibodies.
HPA014484 , HPA014485
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PROGNOSTIC SUMMARY
Prognostic marker in endometrial cancer (favourable).
Endometrial cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Mixed

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA014484
HPA014485

GENE INFORMATION

Gene name

 FZD10 (HGNC Symbol)

Synonyms

 CD350

Description

 Frizzled class receptor 10 (HGNC Symbol)

Entrez gene summary

 This gene is a member of the frizzled gene family. Members of this family encode 7-transmembrane domain proteins that are receptors for the Wingless type MMTV integration site family of signaling proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway. Using array analysis, expression of this intronless gene is significantly up-regulated in two cases of primary colon cancer. [provided by RefSeq, Jul 2008]

Chromosome

 12

Cytoband

 q24.33

Chromosome location (bp)

 130162459 - 130165740

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000111432 (version 83.38)

Entrez gene

 11211

UniProt

 Q9ULW2 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9ULW2

Antibodypedia

 FZD10 antibodies

PROTEIN BROWSER
FZD10-001
FZD10-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
FZD10-001
ENSP00000438460
ENST00000539839
F5H450 [Direct mapping]
Frizzled-10
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Predicted intracellular proteins
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GO:0004930 [G-protein coupled receptor activity]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0017147 [Wnt-protein binding]
GO:0060070 [canonical Wnt signaling pathway]
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 454 aa
48.8 kDa 		No 0
FZD10-201
ENSP00000229030
ENST00000229030
Q9ULW2 [Direct mapping]
Frizzled-10
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CD markers
G-protein coupled receptors
   GPCRs excl olfactory receptors
   Family fz/smo receptors
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   GPCRHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
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GO:0004888 [transmembrane signaling receptor activity]
GO:0004930 [G-protein coupled receptor activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005887 [integral component of plasma membrane]
GO:0007166 [cell surface receptor signaling pathway]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0009986 [cell surface]
GO:0016020 [membrane]
GO:0016055 [Wnt signaling pathway]
GO:0017147 [Wnt-protein binding]
GO:0030182 [neuron differentiation]
GO:0032956 [regulation of actin cytoskeleton organization]
GO:0034260 [negative regulation of GTPase activity]
GO:0038031 [non-canonical Wnt signaling pathway via JNK cascade]
GO:0042813 [Wnt-activated receptor activity]
GO:0043507 [positive regulation of JUN kinase activity]
GO:0043547 [positive regulation of GTPase activity]
GO:0060070 [canonical Wnt signaling pathway]
GO:0071300 [cellular response to retinoic acid]
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 581 aa
65.3 kDa 		Yes 7

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.