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RAB5B

GENERAL INFORMATION

Gene name

 RAB5B

Gene description

 RAB5B, member RAS oncogene family

Protein class

 Predicted intracellular proteins
RAS pathway related proteins

Predicted localization

 Intracellular

Number of transcripts

 7
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Ubiquitous cytoplasmic expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Pending external verification.

Reliability score

 Approved based on 1 antibody.
CAB010224
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PROGNOSTIC SUMMARY
Prognostic marker in breast cancer (unfavourable).
Breast cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
CAB010224

GENE INFORMATION

Gene name

 RAB5B

Synonyms

Description

 RAB5B, member RAS oncogene family (HGNC Symbol)

Entrez gene summary

Chromosome

 12

Cytoband

 q13.2

Chromosome location (bp)

 55973913 - 55996683

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000111540 (version 83.38)

Entrez gene

 5869

UniProt

 P61020 (UniProt - Evidence at protein level)

neXtProt

 NX_P61020

Antibodypedia

 RAB5B antibodies

PROTEIN BROWSER
RAB5B-001
RAB5B-003
RAB5B-004
RAB5B-005
RAB5B-006
RAB5B-007
RAB5B-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
RAB5B-001
ENSP00000353444
ENST00000360299
P61020 [Direct mapping]
Ras-related protein Rab-5B
A0A024RB09 [Target identity:100%; Query identity:100%]
RAB5B, member RAS oncogene family, isoform CRA_a
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Predicted intracellular proteins
RAS pathway related proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003924 [GTPase activity]
GO:0005515 [protein binding]
GO:0005525 [GTP binding]
GO:0005622 [intracellular]
GO:0005768 [endosome]
GO:0005769 [early endosome]
GO:0005886 [plasma membrane]
GO:0006886 [intracellular protein transport]
GO:0006913 [nucleocytoplasmic transport]
GO:0007032 [endosome organization]
GO:0007165 [signal transduction]
GO:0007264 [small GTPase mediated signal transduction]
GO:0015031 [protein transport]
GO:0016020 [membrane]
GO:0019003 [GDP binding]
GO:0019882 [antigen processing and presentation]
GO:0030100 [regulation of endocytosis]
GO:0030139 [endocytic vesicle]
GO:0030742 [GTP-dependent protein binding]
GO:0031901 [early endosome membrane]
GO:0032482 [Rab protein signal transduction]
GO:0042470 [melanosome]
GO:0048227 [plasma membrane to endosome transport]
GO:0070062 [extracellular exosome]
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 215 aa
23.7 kDa 		No 0
RAB5B-003
ENSP00000391319
ENST00000448789
P61020 [Direct mapping]
Ras-related protein Rab-5B
Show all
Predicted intracellular proteins
RAS pathway related proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003924 [GTPase activity]
GO:0005515 [protein binding]
GO:0005525 [GTP binding]
GO:0005622 [intracellular]
GO:0005768 [endosome]
GO:0005769 [early endosome]
GO:0005886 [plasma membrane]
GO:0006886 [intracellular protein transport]
GO:0007165 [signal transduction]
GO:0007264 [small GTPase mediated signal transduction]
GO:0015031 [protein transport]
GO:0016020 [membrane]
GO:0019003 [GDP binding]
GO:0019882 [antigen processing and presentation]
GO:0030100 [regulation of endocytosis]
GO:0030139 [endocytic vesicle]
GO:0030742 [GTP-dependent protein binding]
GO:0031901 [early endosome membrane]
GO:0032482 [Rab protein signal transduction]
GO:0042470 [melanosome]
GO:0048227 [plasma membrane to endosome transport]
GO:0070062 [extracellular exosome]
Show all
 174 aa
19.1 kDa 		No 0
RAB5B-004
ENSP00000450168
ENST00000553116
P61020 [Direct mapping]
Ras-related protein Rab-5B
A0A024RB09 [Target identity:100%; Query identity:100%]
RAB5B, member RAS oncogene family, isoform CRA_a
Show all
Predicted intracellular proteins
RAS pathway related proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003924 [GTPase activity]
GO:0005515 [protein binding]
GO:0005525 [GTP binding]
GO:0005622 [intracellular]
GO:0005768 [endosome]
GO:0005769 [early endosome]
GO:0005886 [plasma membrane]
GO:0006886 [intracellular protein transport]
GO:0006913 [nucleocytoplasmic transport]
GO:0007165 [signal transduction]
GO:0007264 [small GTPase mediated signal transduction]
GO:0015031 [protein transport]
GO:0016020 [membrane]
GO:0019003 [GDP binding]
GO:0019882 [antigen processing and presentation]
GO:0030100 [regulation of endocytosis]
GO:0030139 [endocytic vesicle]
GO:0030742 [GTP-dependent protein binding]
GO:0031901 [early endosome membrane]
GO:0032482 [Rab protein signal transduction]
GO:0042470 [melanosome]
GO:0048227 [plasma membrane to endosome transport]
GO:0070062 [extracellular exosome]
Show all
 215 aa
23.7 kDa 		No 0
RAB5B-005
ENSP00000447895
ENST00000548068
F8VUA5 [Direct mapping]
Ras-related protein Rab-5B
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Predicted intracellular proteins
RAS pathway related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005525 [GTP binding]
GO:0005769 [early endosome]
GO:0006886 [intracellular protein transport]
GO:0007165 [signal transduction]
GO:0007264 [small GTPase mediated signal transduction]
GO:0015031 [protein transport]
GO:0016020 [membrane]
GO:0030100 [regulation of endocytosis]
GO:0030139 [endocytic vesicle]
GO:0032482 [Rab protein signal transduction]
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 115 aa
12.9 kDa 		No 0
RAB5B-006
ENSP00000449762
ENST00000549915
F8VWZ7 [Direct mapping]
Ras-related protein Rab-5B
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Predicted intracellular proteins
RAS pathway related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005525 [GTP binding]
GO:0005769 [early endosome]
GO:0006886 [intracellular protein transport]
GO:0007264 [small GTPase mediated signal transduction]
GO:0030100 [regulation of endocytosis]
GO:0030139 [endocytic vesicle]
GO:0032482 [Rab protein signal transduction]
Show all
 79 aa
8.4 kDa 		No 0
RAB5B-007
ENSP00000449554
ENST00000551459
F8VVZ0 [Direct mapping]
Ras-related protein Rab-5B
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   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
RAS pathway related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005525 [GTP binding]
GO:0005769 [early endosome]
GO:0006886 [intracellular protein transport]
GO:0007264 [small GTPase mediated signal transduction]
GO:0015031 [protein transport]
GO:0030100 [regulation of endocytosis]
GO:0030139 [endocytic vesicle]
GO:0032482 [Rab protein signal transduction]
Show all
 100 aa
11.1 kDa 		No 0
RAB5B-201
ENSP00000487368
ENST00000628569
F8VPW9 [Direct mapping]
Ras-related protein Rab-5B
Show all
Predicted intracellular proteins
RAS pathway related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005525 [GTP binding]
GO:0005769 [early endosome]
GO:0006886 [intracellular protein transport]
GO:0007264 [small GTPase mediated signal transduction]
GO:0030100 [regulation of endocytosis]
GO:0030139 [endocytic vesicle]
GO:0032482 [Rab protein signal transduction]
Show all
 73 aa
7.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.