Fields »
ABOUT
HELP
BLOG
TIMELESS

GENERAL INFORMATION

Gene name

 TIMELESS

Gene description

 Timeless circadian clock

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Mixed

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Nuclear expression in several tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 1 antibody.
HPA060655
SHOW MORE

PROGNOSTIC SUMMARY
Prognostic marker in melanoma (unfavourable), renal cancer (unfavourable) and liver cancer (unfavourable).
Melanoma p<0.001
Renal cancer p<0.001
Liver cancer p<0.001
Show all

RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA060655

GENE INFORMATION

Gene name

 TIMELESS (HGNC Symbol)

Synonyms

 hTIM, TIM, TIM1

Description

 Timeless circadian clock (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is highly conserved and is involved in cell survival after damage or stress, increase in DNA polymerase epsilon activity, maintenance of telomere length, and epithelial cell morphogenesis. The encoded protein also plays a role in the circadian rhythm autoregulatory loop, interacting with the PERIOD genes (PER1, PER2, and PER3) and others to downregulate activation of PER1 by CLOCK/ARNTL. Changes in this gene or its expression may promote prostate cancer, lung cancer, breast cancer, and mental disorders. [provided by RefSeq, Feb 2014]

Chromosome

 12

Cytoband

 q13.3

Chromosome location (bp)

 56416373 - 56449403

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000111602 (version 83.38)

Entrez gene

 8914

UniProt

 Q9UNS1 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9UNS1

Antibodypedia

 TIMELESS antibodies

PROTEIN BROWSER
TIMELESS-001
TIMELESS-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
TIMELESS-001
ENSP00000450607
ENST00000553532
Q9UNS1 [Direct mapping]
Protein timeless homolog
Show all
   Phobius predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000724 [double-strand break repair via homologous recombination]
GO:0000790 [nuclear chromatin]
GO:0002009 [morphogenesis of an epithelium]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0006281 [DNA repair]
GO:0006302 [double-strand break repair]
GO:0006351 [transcription, DNA-templated]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0007067 [mitotic nuclear division]
GO:0007623 [circadian rhythm]
GO:0009582 [detection of abiotic stimulus]
GO:0009628 [response to abiotic stimulus]
GO:0015630 [microtubule cytoskeleton]
GO:0030324 [lung development]
GO:0042752 [regulation of circadian rhythm]
GO:0042803 [protein homodimerization activity]
GO:0044770 [cell cycle phase transition]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0046982 [protein heterodimerization activity]
GO:0048754 [branching morphogenesis of an epithelial tube]
GO:0051301 [cell division]
Show all
 1208 aa
138.7 kDa 		No 0
TIMELESS-002
ENSP00000229201
ENST00000229201
Q9UNS1 [Direct mapping]
Protein timeless homolog
Show all
   Phobius predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000724 [double-strand break repair via homologous recombination]
GO:0000790 [nuclear chromatin]
GO:0002009 [morphogenesis of an epithelium]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0006281 [DNA repair]
GO:0006302 [double-strand break repair]
GO:0006351 [transcription, DNA-templated]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0007067 [mitotic nuclear division]
GO:0007623 [circadian rhythm]
GO:0009582 [detection of abiotic stimulus]
GO:0009628 [response to abiotic stimulus]
GO:0015630 [microtubule cytoskeleton]
GO:0042752 [regulation of circadian rhythm]
GO:0044770 [cell cycle phase transition]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0051301 [cell division]
Show all
 1207 aa
138.5 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.