Cell atlas - NOP2 - The Human Protein Atlas

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NOP2

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TISSUE

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CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS CUSTOM DATA

GENE/PROTEIN

Antibody validation

Dictionary
	Nucleoli

Human cell
	Nucleoli

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GENERAL INFORMATION
Gene name	NOP2
Gene description	NOP2 nucleolar protein
Protein class	Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	15
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the nucleoli.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoli (supported)
Single-cell variation	Single-cell variation in protein expression observed.
Cell cycle dependency	Cell cycle dependent expression determined by custom assay

DATA RELIABILITY
Reliability score	Supported based on 1 antibody. HPA040119
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the nucleoli.

Main location

Nucleoli (supported)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA040119	A-431	Nucleoli
	HPA040119	U-2 OS	Nucleoli	Intensity	Intensity
	HPA040119	U-251 MG	Nucleoli

CUSTOM DATA


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Thumbnail	Antibody	Cell line	Assay	Description
	HPA040119	U-2 OS	Image	Staining of U-2 OS FUCCI cells, to characterize the cell cycle dependency of the protein expression pattern. The FUCCI cells, Fluorescence Ubiquitination Cell Cycle Indicator, are cells tagged with different fluorescent proteins fused to two different cell cycle regulators Cdt1 (expressed in G1 phase) and Geminin (expressed in S and G2 phases) that allows cell cycle monitoring. When both proteins are present, the overlay of the images appear in yellow marking the G1/S transition. NOP2 is mostly expressed during G1, and during S and/or G2.

CELL CYCLE
Summary	Expression has cell cycle dependency according to custom assay
Intensity variation	Nucleoli

GENE INFORMATION
Gene name	NOP2 (HGNC Symbol)
Synonyms	NOL1, NOP120, NSUN1, p120
Description	NOP2 nucleolar protein (HGNC Symbol)
Entrez gene summary
Chromosome	12
Cytoband	p13.31
Chromosome location (bp)	6556863 - 6568691
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000111641 (version 83.38)
Entrez gene	4839
UniProt	P46087 (UniProt - Evidence at protein level)
neXtProt	NX_P46087
Antibodypedia	NOP2 antibodies

PROTEIN BROWSER

NOP2-001	NOP2-002	NOP2-003	NOP2-004	NOP2-005	NOP2-007	NOP2-015	NOP2-016	NOP2-018	NOP2-019	NOP2-021	NOP2-022	NOP2-201	NOP2-202	NOP2-203

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
NOP2-001 ENSP00000371858 ENST00000382421	P46087 [Direct mapping] Probable 28S rRNA (cytosine(4447)-C(5))-methyltransferase Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003723 [RNA binding] GO:0005515 [protein binding] GO:0005730 [nucleolus] GO:0006364 [rRNA processing] GO:0008168 [methyltransferase activity] GO:0008284 [positive regulation of cell proliferation] GO:0008757 [S-adenosylmethionine-dependent methyltransferase activity] GO:0032259 [methylation] GO:0044822 [poly(A) RNA binding] Show all	845 aa 92.9 kDa	No	0
NOP2-002 ENSP00000382392 ENST00000399466	P46087 [Direct mapping] Probable 28S rRNA (cytosine(4447)-C(5))-methyltransferase Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003723 [RNA binding] GO:0005515 [protein binding] GO:0005730 [nucleolus] GO:0006364 [rRNA processing] GO:0008168 [methyltransferase activity] GO:0008284 [positive regulation of cell proliferation] GO:0008757 [S-adenosylmethionine-dependent methyltransferase activity] GO:0032259 [methylation] GO:0044822 [poly(A) RNA binding] Show all	808 aa 89 kDa	No	0
NOP2-003 ENSP00000444437 ENST00000537442	P46087 [Direct mapping] Probable 28S rRNA (cytosine(4447)-C(5))-methyltransferase Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003723 [RNA binding] GO:0005515 [protein binding] GO:0005730 [nucleolus] GO:0006364 [rRNA processing] GO:0008168 [methyltransferase activity] GO:0008284 [positive regulation of cell proliferation] GO:0008757 [S-adenosylmethionine-dependent methyltransferase activity] GO:0032259 [methylation] GO:0044822 [poly(A) RNA binding] Show all	812 aa 89.3 kDa	No	0
NOP2-004 ENSP00000439422 ENST00000545200	P46087 [Direct mapping] Probable 28S rRNA (cytosine(4447)-C(5))-methyltransferase Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003723 [RNA binding] GO:0005515 [protein binding] GO:0005730 [nucleolus] GO:0006364 [rRNA processing] GO:0008168 [methyltransferase activity] GO:0008284 [positive regulation of cell proliferation] GO:0008757 [S-adenosylmethionine-dependent methyltransferase activity] GO:0032259 [methylation] GO:0044822 [poly(A) RNA binding] Show all	628 aa 69.6 kDa	No	0
NOP2-005 ENSP00000443150 ENST00000541778	P46087 [Direct mapping] Probable 28S rRNA (cytosine(4447)-C(5))-methyltransferase Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003723 [RNA binding] GO:0005515 [protein binding] GO:0005730 [nucleolus] GO:0006364 [rRNA processing] GO:0008168 [methyltransferase activity] GO:0008284 [positive regulation of cell proliferation] GO:0008757 [S-adenosylmethionine-dependent methyltransferase activity] GO:0032259 [methylation] GO:0044822 [poly(A) RNA binding] Show all	808 aa 89 kDa	No	0
NOP2-007 ENSP00000313272 ENST00000322166	P46087 [Direct mapping] Probable 28S rRNA (cytosine(4447)-C(5))-methyltransferase Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003723 [RNA binding] GO:0005515 [protein binding] GO:0005730 [nucleolus] GO:0006364 [rRNA processing] GO:0008168 [methyltransferase activity] GO:0008284 [positive regulation of cell proliferation] GO:0008757 [S-adenosylmethionine-dependent methyltransferase activity] GO:0032259 [methylation] GO:0044822 [poly(A) RNA binding] Show all	812 aa 89.3 kDa	No	0
NOP2-015 ENSP00000442742 ENST00000545915	F5H359 [Direct mapping] Probable 28S rRNA (cytosine(4447)-C(5))-methyltransferase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		81 aa 8.9 kDa	No	0
NOP2-016 ENSP00000445402 ENST00000540228	F5H359 [Direct mapping] Probable 28S rRNA (cytosine(4447)-C(5))-methyltransferase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		81 aa 8.9 kDa	No	0
NOP2-018 ENSP00000442895 ENST00000536124	F5H709 [Direct mapping] Probable 28S rRNA (cytosine(4447)-C(5))-methyltransferase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		177 aa 19.1 kDa	No	0
NOP2-019 ENSP00000443035 ENST00000542867	F5H5X6 [Direct mapping] Probable 28S rRNA (cytosine(4447)-C(5))-methyltransferase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		250 aa 27.4 kDa	No	0
NOP2-021 ENSP00000440754 ENST00000542944	F5GYR3 [Direct mapping] Probable 28S rRNA (cytosine(4447)-C(5))-methyltransferase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005730 [nucleolus] GO:0008168 [methyltransferase activity] GO:0032259 [methylation] Show all	275 aa 30.6 kDa	No	0
NOP2-022 ENSP00000441923 ENST00000545492	F5GWB7 [Direct mapping] Probable 28S rRNA (cytosine(4447)-C(5))-methyltransferase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		159 aa 17.2 kDa	No	0
NOP2-201 ENSP00000479236 ENST00000616948	A0A087WV73 [Direct mapping] Probable 28S rRNA (cytosine(4447)-C(5))-methyltransferase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003723 [RNA binding] GO:0006364 [rRNA processing] GO:0008168 [methyltransferase activity] GO:0008757 [S-adenosylmethionine-dependent methyltransferase activity] GO:0032259 [methylation] Show all	855 aa 94.1 kDa	No	0
NOP2-202 ENSP00000484384 ENST00000617555	P46087 [Direct mapping] Probable 28S rRNA (cytosine(4447)-C(5))-methyltransferase Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003723 [RNA binding] GO:0005515 [protein binding] GO:0005730 [nucleolus] GO:0006364 [rRNA processing] GO:0008168 [methyltransferase activity] GO:0008284 [positive regulation of cell proliferation] GO:0008757 [S-adenosylmethionine-dependent methyltransferase activity] GO:0032259 [methylation] GO:0044822 [poly(A) RNA binding] Show all	628 aa 69.6 kDa	No	0
NOP2-203 ENSP00000479320 ENST00000620535	P46087 [Direct mapping] Probable 28S rRNA (cytosine(4447)-C(5))-methyltransferase Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003723 [RNA binding] GO:0005515 [protein binding] GO:0005730 [nucleolus] GO:0006364 [rRNA processing] GO:0008168 [methyltransferase activity] GO:0008284 [positive regulation of cell proliferation] GO:0008757 [S-adenosylmethionine-dependent methyltransferase activity] GO:0032259 [methylation] GO:0044822 [poly(A) RNA binding] Show all	845 aa 92.9 kDa	No	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.