Expression of ACRBP in cancer - Summary - The Human Protein Atlas

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ACRBP

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TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	ACRBP
Gene description	Acrosin binding protein
Protein class	Predicted secreted proteins
Predicted localization	Secreted
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Mixed
HPA (cell line):	Cell line enhanced (HMC-1, U-266/70, U-266/84)
HPA (normal tissue):	Tissue enriched (testis)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Highly selective expression in subsets of cells in seminiferus ducts.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Presumed off target binding observed and disregarded.
Reliability score	Supported based on 2 antibodies. HPA039081 , HPA039082
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Mixed

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA039081	HPA039082

GENE INFORMATION
Gene name	ACRBP (HGNC Symbol)
Synonyms	CT23, OY-TES-1, SP32
Description	Acrosin binding protein (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is similar to proacrosin binding protein sp32 precursor found in mouse, guinea pig, and pig. This protein is located in the sperm acrosome and is thought to function as a binding protein to proacrosin for packaging and condensation of the acrosin zymogen in the acrosomal matrix. This protein is a member of the cancer/testis family of antigens and it is found to be immunogenic. In normal tissues, this mRNA is expressed only in testis, whereas it is detected in a range of different tumor types such as bladder, breast, lung, liver, and colon. [provided by RefSeq, Jul 2008]
Chromosome	12
Cytoband	p13.31
Chromosome location (bp)	6638075 - 6647460
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000111644 (version 83.38)
Entrez gene	84519
UniProt	Q8NEB7 (UniProt - Evidence at transcript level)
neXtProt	NX_Q8NEB7
Antibodypedia	ACRBP antibodies

PROTEIN BROWSER

ACRBP-001	ACRBP-002	ACRBP-008	ACRBP-009

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ACRBP-001 ENSP00000229243 ENST00000229243	Q8NEB7 [Direct mapping] Acrosin-binding protein Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Show all	GO:0001669 [acrosomal vesicle] GO:0003674 [molecular_function] GO:0005576 [extracellular region] GO:0005634 [nucleus] GO:0008150 [biological_process] Show all	543 aa 61.4 kDa	Yes	0
ACRBP-002 ENSP00000402725 ENST00000414226	E7EP66 [Direct mapping] Acrosin-binding protein Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all		510 aa 57.6 kDa	Yes	0
ACRBP-008 ENSP00000438656 ENST00000546114	F5H2C2 [Direct mapping] Acrosin-binding protein Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all		174 aa 19.4 kDa	Yes	0
ACRBP-009 ENSP00000443153 ENST00000536350	F5H5S8 [Direct mapping] Acrosin-binding protein Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all		319 aa 36.2 kDa	Yes	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.