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ENO2

GENERAL INFORMATION

Gene name

 ENO2

Gene description

 Enolase 2 (gamma, neuronal)

Protein class

 Cancer-related genes
Candidate cardiovascular disease genes
Enzymes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 7
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Cell line enhanced (U-87 MG)
HPA (normal tissue):Tissue enriched (cerebral cortex)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Distinct cytoplasmic expression in CNS, peripheral nerves and pancreatic islets.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data.

Reliability score

 Supported based on 2 antibodies.
CAB000063 , CAB073539
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable), liver cancer (unfavourable) and colorectal cancer (unfavourable).
Renal cancer p<0.001
Liver cancer p<0.001
Colorectal cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Testis cancer

STAINING SUMMARY
CAB000063
CAB073539

GENE INFORMATION

Gene name

 ENO2

Synonyms

Description

 Enolase 2 (gamma, neuronal) (HGNC Symbol)

Entrez gene summary

 This gene encodes one of the three enolase isoenzymes found in mammals. This isoenzyme, a homodimer, is found in mature neurons and cells of neuronal origin. A switch from alpha enolase to gamma enolase occurs in neural tissue during development in rats and primates. [provided by RefSeq, Jul 2008]

Chromosome

 12

Cytoband

 p13.31

Chromosome location (bp)

 6913745 - 6923698

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000111674 (version 83.38)

Entrez gene

 2026

UniProt

 P09104 (UniProt - Evidence at protein level)

neXtProt

 NX_P09104

Antibodypedia

 ENO2 antibodies

PROTEIN BROWSER
ENO2-001
ENO2-002
ENO2-003
ENO2-004
ENO2-010
ENO2-013
ENO2-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ENO2-001
ENSP00000438873
ENST00000541477
P09104 [Direct mapping]
Gamma-enolase
Q6FHV6 [Target identity:100%; Query identity:100%]
ENO2 protein; Enolase 2 (Gamma, neuronal), isoform CRA_a; Epididymis secretory protein Li 279; cDNA FLJ42665 fis, clone BRAMY2019989, highly similar to Gamma-enolase (EC 4.2.1.11); cDNA, FLJ92734, Homo sapiens enolase 2, (gamma, neuronal) (ENO2), mRNA
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Enzymes
   ENZYME proteins
   Lyases
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Candidate cardiovascular disease genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000015 [phosphopyruvate hydratase complex]
GO:0000287 [magnesium ion binding]
GO:0004634 [phosphopyruvate hydratase activity]
GO:0005615 [extracellular space]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005975 [carbohydrate metabolic process]
GO:0006006 [glucose metabolic process]
GO:0006094 [gluconeogenesis]
GO:0006096 [glycolytic process]
GO:0044281 [small molecule metabolic process]
GO:0061621 [canonical glycolysis]
GO:0070062 [extracellular exosome]
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 434 aa
47.3 kDa 		No 0
ENO2-002
ENSP00000437402
ENST00000535366
P09104 [Direct mapping]
Gamma-enolase
Q6FHV6 [Target identity:100%; Query identity:100%]
ENO2 protein; Enolase 2 (Gamma, neuronal), isoform CRA_a; Epididymis secretory protein Li 279; cDNA FLJ42665 fis, clone BRAMY2019989, highly similar to Gamma-enolase (EC 4.2.1.11); cDNA, FLJ92734, Homo sapiens enolase 2, (gamma, neuronal) (ENO2), mRNA
Show all
Enzymes
   ENZYME proteins
   Lyases
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Candidate cardiovascular disease genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000015 [phosphopyruvate hydratase complex]
GO:0000287 [magnesium ion binding]
GO:0001917 [photoreceptor inner segment]
GO:0004634 [phosphopyruvate hydratase activity]
GO:0005615 [extracellular space]
GO:0005622 [intracellular]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005975 [carbohydrate metabolic process]
GO:0006006 [glucose metabolic process]
GO:0006094 [gluconeogenesis]
GO:0006096 [glycolytic process]
GO:0043025 [neuronal cell body]
GO:0043204 [perikaryon]
GO:0043209 [myelin sheath]
GO:0044281 [small molecule metabolic process]
GO:0061621 [canonical glycolysis]
GO:0070062 [extracellular exosome]
Show all
 434 aa
47.3 kDa 		No 0
ENO2-003
ENSP00000441490
ENST00000538763
P09104 [Direct mapping]
Gamma-enolase
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Enzymes
   ENZYME proteins
   Lyases
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Candidate cardiovascular disease genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000015 [phosphopyruvate hydratase complex]
GO:0000287 [magnesium ion binding]
GO:0004634 [phosphopyruvate hydratase activity]
GO:0005615 [extracellular space]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005975 [carbohydrate metabolic process]
GO:0006006 [glucose metabolic process]
GO:0006094 [gluconeogenesis]
GO:0006096 [glycolytic process]
GO:0044281 [small molecule metabolic process]
GO:0061621 [canonical glycolysis]
GO:0070062 [extracellular exosome]
Show all
 391 aa
42.7 kDa 		No 0
ENO2-004
ENSP00000438062
ENST00000545045
F5H0C8 [Direct mapping]
Enolase
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000015 [phosphopyruvate hydratase complex]
GO:0000287 [magnesium ion binding]
GO:0004634 [phosphopyruvate hydratase activity]
GO:0006096 [glycolytic process]
Show all
 315 aa
34.8 kDa 		No 0
ENO2-010
ENSP00000476112
ENST00000543975
U3KQQ1 [Direct mapping]
Enolase
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000015 [phosphopyruvate hydratase complex]
GO:0000287 [magnesium ion binding]
GO:0004634 [phosphopyruvate hydratase activity]
GO:0006096 [glycolytic process]
Show all
 86 aa
9.4 kDa 		No 0
ENO2-013
ENSP00000445788
ENST00000537688
F5H1C3 [Direct mapping]
Gamma-enolase
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000015 [phosphopyruvate hydratase complex]
GO:0000287 [magnesium ion binding]
GO:0004634 [phosphopyruvate hydratase activity]
GO:0006096 [glycolytic process]
Show all
 103 aa
11.2 kDa 		No 0
ENO2-201
ENSP00000229277
ENST00000229277
P09104 [Direct mapping]
Gamma-enolase
Q6FHV6 [Target identity:100%; Query identity:100%]
ENO2 protein; Enolase 2 (Gamma, neuronal), isoform CRA_a; Epididymis secretory protein Li 279; cDNA FLJ42665 fis, clone BRAMY2019989, highly similar to Gamma-enolase (EC 4.2.1.11); cDNA, FLJ92734, Homo sapiens enolase 2, (gamma, neuronal) (ENO2), mRNA
Show all
Enzymes
   ENZYME proteins
   Lyases
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Candidate cardiovascular disease genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000015 [phosphopyruvate hydratase complex]
GO:0000287 [magnesium ion binding]
GO:0004634 [phosphopyruvate hydratase activity]
GO:0005615 [extracellular space]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005975 [carbohydrate metabolic process]
GO:0006006 [glucose metabolic process]
GO:0006094 [gluconeogenesis]
GO:0006096 [glycolytic process]
GO:0044281 [small molecule metabolic process]
GO:0061621 [canonical glycolysis]
GO:0070062 [extracellular exosome]
Show all
 434 aa
47.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.