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PTPN6

GENERAL INFORMATION

Gene name

 PTPN6

Gene description

 Protein tyrosine phosphatase, non-receptor type 6

Protein class

 Enzymes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 7
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Cell line enhanced (HEL, HMC-1, THP-1)
HPA (normal tissue):Mixed

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Distinct cytoplasmic expression in immune tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 3 antibodies.
HPA001466 , CAB004572 , CAB072845
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PROGNOSTIC SUMMARY
Prognostic marker in urothelial cancer (favourable), cervical cancer (favourable), colorectal cancer (unfavourable) and endometrial cancer (favourable).
Urothelial cancer p<0.001
Cervical cancer p<0.001
Colorectal cancer p<0.001
Endometrial cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA001466
CAB004572
CAB072845

GENE INFORMATION

Gene name

 PTPN6 (HGNC Symbol)

Synonyms

 HCP, HCPH, PTP-1C, SHP-1, SHP1

Description

 Protein tyrosine phosphatase, non-receptor type 6 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. N-terminal part of this PTP contains two tandem Src homolog (SH2) domains, which act as protein phospho-tyrosine binding domains, and mediate the interaction of this PTP with its substrates. This PTP is expressed primarily in hematopoietic cells, and functions as an important regulator of multiple signaling pathways in hematopoietic cells. This PTP has been shown to interact with, and dephosphorylate a wide spectrum of phospho-proteins involved in hematopoietic cell signaling. Multiple alternatively spliced variants of this gene, which encode distinct isoforms, have been reported. [provided by RefSeq, Jul 2008]

Chromosome

 12

Cytoband

 p13.31

Chromosome location (bp)

 6946468 - 6961316

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000111679 (version 83.38)

Entrez gene

 5777

UniProt

 P29350 (UniProt - Evidence at protein level)

neXtProt

 NX_P29350

Antibodypedia

 PTPN6 antibodies

PROTEIN BROWSER
PTPN6-001
PTPN6-008
PTPN6-014
PTPN6-018
PTPN6-021
PTPN6-023
PTPN6-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PTPN6-001
ENSP00000382376
ENST00000399448
P29350 [Direct mapping]
Tyrosine-protein phosphatase non-receptor type 6
Q53XS4 [Target identity:100%; Query identity:100%]
Tyrosine-protein phosphatase non-receptor type
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Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0004725 [protein tyrosine phosphatase activity]
GO:0005001 [transmembrane receptor protein tyrosine phosphatase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006470 [protein dephosphorylation]
GO:0006915 [apoptotic process]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007596 [blood coagulation]
GO:0008283 [cell proliferation]
GO:0008284 [positive regulation of cell proliferation]
GO:0008285 [negative regulation of cell proliferation]
GO:0014068 [positive regulation of phosphatidylinositol 3-kinase signaling]
GO:0016020 [membrane]
GO:0016311 [dephosphorylation]
GO:0016791 [phosphatase activity]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0019901 [protein kinase binding]
GO:0030154 [cell differentiation]
GO:0031295 [T cell costimulation]
GO:0035335 [peptidyl-tyrosine dephosphorylation]
GO:0050732 [negative regulation of peptidyl-tyrosine phosphorylation]
GO:0050900 [leukocyte migration]
GO:0060333 [interferon-gamma-mediated signaling pathway]
GO:0060334 [regulation of interferon-gamma-mediated signaling pathway]
GO:0060337 [type I interferon signaling pathway]
GO:0060338 [regulation of type I interferon-mediated signaling pathway]
GO:0060397 [JAK-STAT cascade involved in growth hormone signaling pathway]
GO:0070062 [extracellular exosome]
GO:0070372 [regulation of ERK1 and ERK2 cascade]
GO:2000045 [regulation of G1/S transition of mitotic cell cycle]
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 597 aa
67.7 kDa 		No 0
PTPN6-008
ENSP00000326010
ENST00000318974
P29350 [Direct mapping]
Tyrosine-protein phosphatase non-receptor type 6
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Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004725 [protein tyrosine phosphatase activity]
GO:0005001 [transmembrane receptor protein tyrosine phosphatase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006470 [protein dephosphorylation]
GO:0006915 [apoptotic process]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007596 [blood coagulation]
GO:0008283 [cell proliferation]
GO:0008284 [positive regulation of cell proliferation]
GO:0008285 [negative regulation of cell proliferation]
GO:0014068 [positive regulation of phosphatidylinositol 3-kinase signaling]
GO:0016020 [membrane]
GO:0016311 [dephosphorylation]
GO:0016791 [phosphatase activity]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0019901 [protein kinase binding]
GO:0030154 [cell differentiation]
GO:0031295 [T cell costimulation]
GO:0035335 [peptidyl-tyrosine dephosphorylation]
GO:0050732 [negative regulation of peptidyl-tyrosine phosphorylation]
GO:0050900 [leukocyte migration]
GO:0060333 [interferon-gamma-mediated signaling pathway]
GO:0060334 [regulation of interferon-gamma-mediated signaling pathway]
GO:0060337 [type I interferon signaling pathway]
GO:0060338 [regulation of type I interferon-mediated signaling pathway]
GO:0060397 [JAK-STAT cascade involved in growth hormone signaling pathway]
GO:0070062 [extracellular exosome]
GO:0070372 [regulation of ERK1 and ERK2 cascade]
GO:2000045 [regulation of G1/S transition of mitotic cell cycle]
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 595 aa
67.6 kDa 		No 0
PTPN6-014
ENSP00000438740
ENST00000538715
F5H0N8 [Direct mapping]
Tyrosine-protein phosphatase non-receptor type 6
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 165 aa
18.5 kDa 		No 0
PTPN6-018
ENSP00000443393
ENST00000543115
F5H5H9 [Direct mapping]
Tyrosine-protein phosphatase non-receptor type 6
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 130 aa
14.6 kDa 		No 0
PTPN6-021
ENSP00000440114
ENST00000542462
F5GY79 [Direct mapping]
Tyrosine-protein phosphatase non-receptor type 6
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 144 aa
16.1 kDa 		No 0
PTPN6-023
ENSP00000445646
ENST00000541698
F5H1Z8 [Direct mapping]
Tyrosine-protein phosphatase non-receptor type 6
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 151 aa
17.1 kDa 		No 0
PTPN6-201
ENSP00000391592
ENST00000456013
P29350 [Direct mapping]
Tyrosine-protein phosphatase non-receptor type 6
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Enzymes
   ENZYME proteins
   Hydrolases
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001784 [phosphotyrosine binding]
GO:0002244 [hematopoietic progenitor cell differentiation]
GO:0002924 [negative regulation of humoral immune response mediated by circulating immunoglobulin]
GO:0004725 [protein tyrosine phosphatase activity]
GO:0005001 [transmembrane receptor protein tyrosine phosphatase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005911 [cell-cell junction]
GO:0006470 [protein dephosphorylation]
GO:0006915 [apoptotic process]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007596 [blood coagulation]
GO:0008283 [cell proliferation]
GO:0008284 [positive regulation of cell proliferation]
GO:0008285 [negative regulation of cell proliferation]
GO:0014068 [positive regulation of phosphatidylinositol 3-kinase signaling]
GO:0016020 [membrane]
GO:0016311 [dephosphorylation]
GO:0016791 [phosphatase activity]
GO:0017124 [SH3 domain binding]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0019901 [protein kinase binding]
GO:0030154 [cell differentiation]
GO:0030220 [platelet formation]
GO:0031295 [T cell costimulation]
GO:0033277 [abortive mitotic cell cycle]
GO:0033630 [positive regulation of cell adhesion mediated by integrin]
GO:0035335 [peptidyl-tyrosine dephosphorylation]
GO:0035556 [intracellular signal transduction]
GO:0035855 [megakaryocyte development]
GO:0042105 [alpha-beta T cell receptor complex]
GO:0042130 [negative regulation of T cell proliferation]
GO:0042169 [SH2 domain binding]
GO:0042267 [natural killer cell mediated cytotoxicity]
GO:0043407 [negative regulation of MAP kinase activity]
GO:0043409 [negative regulation of MAPK cascade]
GO:0045577 [regulation of B cell differentiation]
GO:0050732 [negative regulation of peptidyl-tyrosine phosphorylation]
GO:0050853 [B cell receptor signaling pathway]
GO:0050859 [negative regulation of B cell receptor signaling pathway]
GO:0050860 [negative regulation of T cell receptor signaling pathway]
GO:0050900 [leukocyte migration]
GO:0051279 [regulation of release of sequestered calcium ion into cytosol]
GO:0060333 [interferon-gamma-mediated signaling pathway]
GO:0060334 [regulation of interferon-gamma-mediated signaling pathway]
GO:0060337 [type I interferon signaling pathway]
GO:0060338 [regulation of type I interferon-mediated signaling pathway]
GO:0060397 [JAK-STAT cascade involved in growth hormone signaling pathway]
GO:0070062 [extracellular exosome]
GO:0070372 [regulation of ERK1 and ERK2 cascade]
GO:0070527 [platelet aggregation]
GO:2000045 [regulation of G1/S transition of mitotic cell cycle]
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 624 aa
70.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.