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LDHB

GENERAL INFORMATION

Gene name

 LDHB

Gene description

 Lactate dehydrogenase B

Protein class

 Disease related genes
Enzymes
Plasma proteins
Potential drug targets
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 2 antibodies.
HPA019007 , CAB004641
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable).
Renal cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA019007
CAB004641

GENE INFORMATION

Gene name

 LDHB

Synonyms

Description

 Lactate dehydrogenase B (HGNC Symbol)

Entrez gene summary

 This gene encodes the B subunit of lactate dehydrogenase enzyme, which catalyzes the interconversion of pyruvate and lactate with concomitant interconversion of NADH and NAD+ in a post-glycolysis process. Recent studies have shown that two protein isoforms are produced from the same mRNA by use of alternative in-frame translation termination codons via a stop codon readthrough mechanism, and that these C-terminally distinct isoforms have different subcellular localization. Alternatively spliced transcript variants have also been found for this gene. Mutations in this gene are associated with lactate dehydrogenase B deficiency. Pseudogenes have been identified on chromosomes X, 5 and 13. [provided by RefSeq, Oct 2015]

Chromosome

 12

Cytoband

 p12.1

Chromosome location (bp)

 21635342 - 21757857

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000111716 (version 83.38)

Entrez gene

 3945

UniProt

 P07195 (UniProt - Evidence at protein level)

neXtProt

 NX_P07195

Antibodypedia

 LDHB antibodies

PROTEIN BROWSER
LDHB-001
LDHB-002
LDHB-003
LDHB-004
LDHB-010

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
LDHB-001
ENSP00000229319
ENST00000350669
P07195 [Direct mapping]
L-lactate dehydrogenase B chain
Q5U077 [Target identity:100%; Query identity:100%]
L-lactate dehydrogenase
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Enzymes
   ENZYME proteins
   Oxidoreductases
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0003824 [catalytic activity]
GO:0004459 [L-lactate dehydrogenase activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005975 [carbohydrate metabolic process]
GO:0006090 [pyruvate metabolic process]
GO:0016020 [membrane]
GO:0016491 [oxidoreductase activity]
GO:0016616 [oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor]
GO:0019752 [carboxylic acid metabolic process]
GO:0044237 [cellular metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0045121 [membrane raft]
GO:0055114 [oxidation-reduction process]
GO:0070062 [extracellular exosome]
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 334 aa
36.6 kDa 		No 0
LDHB-002
ENSP00000379386
ENST00000396076
P07195 [Direct mapping]
L-lactate dehydrogenase B chain
Q5U077 [Target identity:100%; Query identity:100%]
L-lactate dehydrogenase
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Enzymes
   ENZYME proteins
   Oxidoreductases
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003824 [catalytic activity]
GO:0004457 [lactate dehydrogenase activity]
GO:0004459 [L-lactate dehydrogenase activity]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005829 [cytosol]
GO:0005975 [carbohydrate metabolic process]
GO:0006089 [lactate metabolic process]
GO:0006090 [pyruvate metabolic process]
GO:0016020 [membrane]
GO:0016491 [oxidoreductase activity]
GO:0016616 [oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor]
GO:0019674 [NAD metabolic process]
GO:0019752 [carboxylic acid metabolic process]
GO:0019900 [kinase binding]
GO:0042802 [identical protein binding]
GO:0043209 [myelin sheath]
GO:0044237 [cellular metabolic process]
GO:0044281 [small molecule metabolic process]
GO:0045121 [membrane raft]
GO:0051287 [NAD binding]
GO:0055114 [oxidation-reduction process]
GO:0070062 [extracellular exosome]
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 334 aa
36.6 kDa 		No 0
LDHB-003
ENSP00000398015
ENST00000450584
C9J7H8 [Direct mapping]
L-lactate dehydrogenase B chain
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   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0016491 [oxidoreductase activity]
GO:0016616 [oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor]
GO:0019752 [carboxylic acid metabolic process]
GO:0055114 [oxidation-reduction process]
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 137 aa
14.8 kDa 		No 0
LDHB-004
ENSP00000379385
ENST00000396075
A8MW50 [Direct mapping]
L-lactate dehydrogenase
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   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003824 [catalytic activity]
GO:0004459 [L-lactate dehydrogenase activity]
GO:0005975 [carbohydrate metabolic process]
GO:0016491 [oxidoreductase activity]
GO:0016616 [oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor]
GO:0019752 [carboxylic acid metabolic process]
GO:0055114 [oxidation-reduction process]
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 232 aa
25.2 kDa 		No 0
LDHB-010
ENSP00000442680
ENST00000539782
F5H793 [Direct mapping]
L-lactate dehydrogenase B chain
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   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0016491 [oxidoreductase activity]
GO:0016616 [oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor]
GO:0019752 [carboxylic acid metabolic process]
GO:0055114 [oxidation-reduction process]
Show all
 102 aa
10.8 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.