Fields »
ABOUT
HELP
BLOG
CMAS

GENERAL INFORMATION

Gene name

 CMAS

Gene description

 Cytidine monophosphate N-acetylneuraminic acid synthetase

Protein class

 Enzymes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Ubiquitous nuclear expression.

DATA RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data.

Reliability score

 Supported based on 1 antibody.
HPA039905
SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Placenta

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 CMAS

Synonyms

Description

 Cytidine monophosphate N-acetylneuraminic acid synthetase (HGNC Symbol)

Entrez gene summary

 Sialic acids are a family of nine-carbon sugars on cell surface glycoproteins and glycolipids that play a pivotal role in determining the structure and function of many animal tissues. The pattern of cell surface sialylation is highly regulated during embryonic development and N-glycosylation is a common post-translational modification during cellular differentiation. Sialic acids play important roles in cell-cell communications and immune responses. Sialylated glycoprotein and glycolipid formation requires the activation of a sialic acid to a cytidine monophosphate (CMP) diester by the enzyme encoded by this gene: CMP-N-acetylneuraminic acid synthetase. [provided by RefSeq, Jul 2012]

Chromosome

 12

Cytoband

 p12.1

Chromosome location (bp)

 22046174 - 22065674

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000111726 (version 83.38)

Entrez gene

 55907

UniProt

 Q8NFW8 (UniProt - Evidence at protein level)

neXtProt

 NX_Q8NFW8

Antibodypedia

 CMAS antibodies

PROTEIN BROWSER
CMAS-001
CMAS-003

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CMAS-001
ENSP00000229329
ENST00000229329
Q8NFW8 [Direct mapping]
N-acylneuraminate cytidylyltransferase
Show all
Enzymes
   ENZYME proteins
   Transferases
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005829 [cytosol]
GO:0006054 [N-acetylneuraminate metabolic process]
GO:0006488 [dolichol-linked oligosaccharide biosynthetic process]
GO:0008781 [N-acylneuraminate cytidylyltransferase activity]
GO:0016020 [membrane]
GO:0018279 [protein N-linked glycosylation via asparagine]
GO:0043687 [post-translational protein modification]
GO:0044267 [cellular protein metabolic process]
Show all
 434 aa
48.4 kDa 		No 0
CMAS-003
ENSP00000440605
ENST00000538498
F5GYM0 [Direct mapping]
N-acylneuraminate cytidylyltransferase
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 97 aa
11.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.