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HCFC2

GENERAL INFORMATION

Gene name

 HCFC2

Gene description

 Host cell factor C2

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Mixed
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic and nuclear expression in several tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data. Pending external verification.

Reliability score

 Approved based on 1 antibody.
HPA006227
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA006227

GENE INFORMATION

Gene name

 HCFC2 (HGNC Symbol)

Synonyms

 HCF-2

Description

 Host cell factor C2 (HGNC Symbol)

Entrez gene summary

 This gene encodes one of two proteins which interact with VP16, a herpes simplex virus protein that initiates virus infection. Both the encoded protein and the original Herpes host cell factor interact with VP16 through a beta-propeller domain. The original Herpes host cell factor, however, is effective at initiating viral infection while the encoded protein is not. Transcripts of varying length due to alternative polyadenylation signals have been described. [provided by RefSeq, Jul 2008]

Chromosome

 12

Cytoband

 q23.3

Chromosome location (bp)

 104064457 - 104106524

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000111727 (version 83.38)

Entrez gene

 29915

UniProt

 Q9Y5Z7 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9Y5Z7

Antibodypedia

 HCFC2 antibodies

PROTEIN BROWSER
HCFC2-001
HCFC2-004

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
HCFC2-001
ENSP00000229330
ENST00000229330
Q9Y5Z7 [Direct mapping]
Host cell factor 2
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0003713 [transcription coactivator activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005886 [plasma membrane]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0016032 [viral process]
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 792 aa
86.8 kDa 		No 0
HCFC2-004
ENSP00000447952
ENST00000550444
F8VU09 [Direct mapping]
Host cell factor 2
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 78 aa
9.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.