Expression of CLEC4A in cancer - Summary - The Human Protein Atlas

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CLEC4A

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	CLEC4A
Gene description	C-type lectin domain family 4, member A
Protein class	Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Mixed
HPA (normal tissue):	Tissue enhanced (appendix)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Expression in lymphoid cells.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining not consistent with RNA expression data. Presumed off target binding observed and disregarded. External characterization data supports antibody staining.
Reliability score	Uncertain based on 1 antibody. HPA007842
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

Pancreatic cancer

STAINING SUMMARY

HPA007842

GENE INFORMATION
Gene name	CLEC4A (HGNC Symbol)
Synonyms	CD367, CLECSF6, DCIR, DDB27
Description	C-type lectin domain family 4, member A (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response. The encoded type 2 transmembrane protein may play a role in inflammatory and immune response. Multiple transcript variants encoding distinct isoforms have been identified for this gene. This gene is closely linked to other CTL/CTLD superfamily members on chromosome 12p13 in the natural killer gene complex region. [provided by RefSeq, Jul 2008]
Chromosome	12
Cytoband	p13.31
Chromosome location (bp)	8123632 - 8138607
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000111729 (version 83.38)
Entrez gene	50856
UniProt	Q9UMR7 (UniProt - Evidence at protein level)
neXtProt	NX_Q9UMR7
Antibodypedia	CLEC4A antibodies

PROTEIN BROWSER

CLEC4A-001	CLEC4A-002	CLEC4A-003	CLEC4A-004	CLEC4A-005

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CLEC4A-001 ENSP00000229332 ENST00000229332	Q9UMR7 [Direct mapping] C-type lectin domain family 4 member A Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Show all	GO:0002223 [stimulatory C-type lectin receptor signaling pathway] GO:0002250 [adaptive immune response] GO:0004888 [transmembrane signaling receptor activity] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0007155 [cell adhesion] GO:0007166 [cell surface receptor signaling pathway] GO:0030246 [carbohydrate binding] GO:0045087 [innate immune response] Show all	237 aa 27.5 kDa	No	1
CLEC4A-002 ENSP00000247243 ENST00000352620	Q9UMR7 [Direct mapping] C-type lectin domain family 4 member A Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Show all	GO:0002223 [stimulatory C-type lectin receptor signaling pathway] GO:0002250 [adaptive immune response] GO:0004888 [transmembrane signaling receptor activity] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0007155 [cell adhesion] GO:0007166 [cell surface receptor signaling pathway] GO:0030246 [carbohydrate binding] GO:0045087 [innate immune response] Show all	204 aa 23.6 kDa	No	1
CLEC4A-003 ENSP00000443082 ENST00000546339	H0YGF9 [Direct mapping] C-type lectin domain family 4 member A Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0016021 [integral component of membrane] Show all	84 aa 9.2 kDa	No	1
CLEC4A-004 ENSP00000344646 ENST00000345999	Q9UMR7 [Direct mapping] C-type lectin domain family 4 member A Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Show all	GO:0002223 [stimulatory C-type lectin receptor signaling pathway] GO:0002250 [adaptive immune response] GO:0004888 [transmembrane signaling receptor activity] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0007155 [cell adhesion] GO:0007166 [cell surface receptor signaling pathway] GO:0030246 [carbohydrate binding] GO:0045087 [innate immune response] Show all	165 aa 19.3 kDa	No	0
CLEC4A-005 ENSP00000353690 ENST00000360500	Q9UMR7 [Direct mapping] C-type lectin domain family 4 member A Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Show all	GO:0002223 [stimulatory C-type lectin receptor signaling pathway] GO:0002250 [adaptive immune response] GO:0004888 [transmembrane signaling receptor activity] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0007155 [cell adhesion] GO:0007166 [cell surface receptor signaling pathway] GO:0030246 [carbohydrate binding] GO:0045087 [innate immune response] Show all	198 aa 23.2 kDa	No	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.