Fields »
ABOUT
HELP
BLOG
TDP2

GENERAL INFORMATION

Gene name

 TDP2

Gene description

 Tyrosyl-DNA phosphodiesterase 2

Protein class

 Predicted intracellular proteins
Predicted secreted proteins

Predicted localization

 Intracellular,Secreted

Number of transcripts

 2
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic and nuclear staining in glandular cells of gastrointestinal tract.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 1 antibody.
CAB073398
SHOW MORE

PROGNOSTIC SUMMARY
Prognostic marker in ovarian cancer (favourable), urothelial cancer (favourable) and prostate cancer (unfavourable).
Ovarian cancer p<0.001
Urothelial cancer p<0.001
Prostate cancer p<0.001
Show all

RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer

STAINING SUMMARY
CAB073398

GENE INFORMATION

Gene name

 TDP2 (HGNC Symbol)

Synonyms

 TTRAP

Description

 Tyrosyl-DNA phosphodiesterase 2 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of a superfamily of divalent cation-dependent phosphodiesterases. The encoded protein associates with CD40, tumor necrosis factor (TNF) receptor-75 and TNF receptor associated factors (TRAFs), and inhibits nuclear factor-kappa-B activation. This protein has sequence and structural similarities with APE1 endonuclease, which is involved in both DNA repair and the activation of transcription factors. [provided by RefSeq, Jul 2008]

Chromosome

 6

Cytoband

 p22.3

Chromosome location (bp)

 24649977 - 24667033

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000111802 (version 83.38)

Entrez gene

 51567

UniProt

 O95551 (UniProt - Evidence at protein level)

neXtProt

 NX_O95551

Antibodypedia

 TDP2 antibodies

PROTEIN BROWSER
TDP2-001
TDP2-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
TDP2-001
ENSP00000367440
ENST00000378198
O95551 [Direct mapping]
Tyrosyl-DNA phosphodiesterase 2
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000287 [magnesium ion binding]
GO:0003697 [single-stranded DNA binding]
GO:0003714 [transcription corepressor activity]
GO:0004518 [nuclease activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0006302 [double-strand break repair]
GO:0007166 [cell surface receptor signaling pathway]
GO:0016605 [PML body]
GO:0030145 [manganese ion binding]
GO:0036317 [tyrosyl-RNA phosphodiesterase activity]
GO:0045171 [intercellular bridge]
GO:0070260 [5'-tyrosyl-DNA phosphodiesterase activity]
GO:0090305 [nucleic acid phosphodiester bond hydrolysis]
GO:1903507 [negative regulation of nucleic acid-templated transcription]
Show all
 362 aa
40.9 kDa 		No 0
TDP2-002
ENSP00000345345
ENST00000341060
X6R5A3 [Direct mapping]
TRAF and TNF receptor associated protein, isoform CRA_b; Tyrosyl-DNA phosphodiesterase 2
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 304 aa
34.5 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.