Expression of DSE in cancer - Summary - The Human Protein Atlas

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DSE

TISSUE

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CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	DSE
Gene description	Dermatan sulfate epimerase
Protein class	Disease related genes Enzymes Potential drug targets Predicted membrane proteins Predicted secreted proteins
Predicted localization	Membrane,Secreted
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Mixed
HPA (cell line):	Mixed
HPA (normal tissue):	Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic and nuclear expression in several tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data.
Reliability score	Uncertain based on 1 antibody. HPA014764
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable), cervical cancer (unfavourable) and ovarian cancer (unfavourable).
Renal cancer p<0.001 Cervical cancer p<0.001 Ovarian cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Mixed

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA014764

GENE INFORMATION
Gene name	DSE (HGNC Symbol)
Synonyms	DSEPI, SART2
Description	Dermatan sulfate epimerase (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a tumor-rejection antigen. This antigen possesses tumor epitopes capable of inducing HLA-A24-restricted and tumor-specific cytotoxic T lymphocytes in cancer patients and may be useful for specific immunotherapy. This gene product is localized to the endoplasmic reticulum. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
Chromosome	6
Cytoband	q22.1
Chromosome location (bp)	116254173 - 116444860
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000111817 (version 83.38)
Entrez gene	29940
UniProt	Q9UL01 (UniProt - Evidence at protein level)
neXtProt	NX_Q9UL01
Antibodypedia	DSE antibodies

PROTEIN BROWSER

DSE-002	DSE-003	DSE-005	DSE-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
DSE-002 ENSP00000332151 ENST00000331677	Q9UL01 [Direct mapping] Dermatan-sulfate epimerase Show all	Enzymes ENZYME proteins Isomerase Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014) Show all	GO:0000139 [Golgi membrane] GO:0005783 [endoplasmic reticulum] GO:0005794 [Golgi apparatus] GO:0005975 [carbohydrate metabolic process] GO:0015012 [heparan sulfate proteoglycan biosynthetic process] GO:0016021 [integral component of membrane] GO:0030203 [glycosaminoglycan metabolic process] GO:0030204 [chondroitin sulfate metabolic process] GO:0030206 [chondroitin sulfate biosynthetic process] GO:0030208 [dermatan sulfate biosynthetic process] GO:0044281 [small molecule metabolic process] GO:0047757 [chondroitin-glucuronate 5-epimerase activity] Show all	958 aa 109.8 kDa	Yes	2
DSE-003 ENSP00000404049 ENST00000452085	Q9UL01 [Direct mapping] Dermatan-sulfate epimerase Show all	Enzymes ENZYME proteins Isomerase Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000139 [Golgi membrane] GO:0005783 [endoplasmic reticulum] GO:0005794 [Golgi apparatus] GO:0005975 [carbohydrate metabolic process] GO:0015012 [heparan sulfate proteoglycan biosynthetic process] GO:0016021 [integral component of membrane] GO:0030203 [glycosaminoglycan metabolic process] GO:0030204 [chondroitin sulfate metabolic process] GO:0030206 [chondroitin sulfate biosynthetic process] GO:0030208 [dermatan sulfate biosynthetic process] GO:0044281 [small molecule metabolic process] GO:0047757 [chondroitin-glucuronate 5-epimerase activity] Show all	958 aa 109.8 kDa	Yes	2
DSE-005 ENSP00000397597 ENST00000430252	X6REM1 [Direct mapping] Dermatan-sulfate epimerase Show all	MEMSAT3 predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		144 aa 16.5 kDa	Yes	0
DSE-201 ENSP00000352567 ENST00000359564	Q9UL01 [Direct mapping] Dermatan-sulfate epimerase Show all	Enzymes ENZYME proteins Isomerase Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000139 [Golgi membrane] GO:0005783 [endoplasmic reticulum] GO:0005794 [Golgi apparatus] GO:0005975 [carbohydrate metabolic process] GO:0015012 [heparan sulfate proteoglycan biosynthetic process] GO:0016021 [integral component of membrane] GO:0030203 [glycosaminoglycan metabolic process] GO:0030204 [chondroitin sulfate metabolic process] GO:0030206 [chondroitin sulfate biosynthetic process] GO:0030208 [dermatan sulfate biosynthetic process] GO:0044281 [small molecule metabolic process] GO:0047757 [chondroitin-glucuronate 5-epimerase activity] Show all	958 aa 109.8 kDa	Yes	2

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.