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RSPH4A

GENERAL INFORMATION

Gene name

 RSPH4A

Gene description

 Radial spoke head 4 homolog A (Chlamydomonas)

Protein class

 Disease related genes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enriched (fallopian tube)
GTEx:Tissue enhanced (fallopian tube)
FANTOM5:Group enriched (caudate, epididymis, lung, ovary, pituitary gland, testis)

Protein evidence

 Evidence at protein level

Protein expression

 Selective expression in ciliated cells.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Presumed off target binding observed and disregarded.

Reliability score

 Supported based on 3 antibodies.
HPA031196 , HPA031197 , HPA031198
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Fallopian tube

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (fallopian tube)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (fallopian tube)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (caudate, epididymis, lung, ovary, pituitary gland, testis)

GENE INFORMATION

Gene name

 RSPH4A (HGNC Symbol)

Synonyms

 CILD11, dJ412I7.1, FLJ37974, RSHL3, RSPH6B

Description

 Radial spoke head 4 homolog A (Chlamydomonas) (HGNC Symbol)

Entrez gene summary

 This gene encodes a protein that appears to be a component the radial spoke head, as determined by homology to similar proteins in the biflagellate alga Chlamydomonas reinhardtii and other ciliates. Radial spokes, which are regularly spaced along cilia, sperm, and flagella axonemes, consist of a thin 'stalk' and a bulbous 'head' that form a signal transduction scaffold between the central pair of microtubules and dynein. Mutations in this gene cause primary ciliary dyskinesia 1, a disease arising from dysmotility of motile cilia and sperm. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2009]

Chromosome

 6

Cytoband

 q22.1

Chromosome location (bp)

 116616479 - 116632985

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000111834 (version 83.38)

Entrez gene

 345895

UniProt

 Q5TD94 (UniProt - Evidence at protein level)

neXtProt

 NX_Q5TD94

Antibodypedia

 RSPH4A antibodies

PROTEIN BROWSER
RSPH4A-001
RSPH4A-002
RSPH4A-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
RSPH4A-001
ENSP00000357569
ENST00000368580
Q5TD94 [Direct mapping]
Radial spoke head protein 4 homolog A
Show all
Predicted intracellular proteins
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001534 [radial spoke]
GO:0003341 [cilium movement]
GO:0003674 [molecular_function]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005856 [cytoskeleton]
GO:0005930 [axoneme]
GO:0031514 [motile cilium]
GO:0035082 [axoneme assembly]
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 469 aa
52.6 kDa 		No 0
RSPH4A-002
ENSP00000229554
ENST00000229554
Q5TD94 [Direct mapping]
Radial spoke head protein 4 homolog A
Show all
Predicted intracellular proteins
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001534 [radial spoke]
GO:0003341 [cilium movement]
GO:0003674 [molecular_function]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005856 [cytoskeleton]
GO:0005930 [axoneme]
GO:0031514 [motile cilium]
GO:0035082 [axoneme assembly]
Show all
 716 aa
80.7 kDa 		No 0
RSPH4A-201
ENSP00000357570
ENST00000368581
Q5TD94 [Direct mapping]
Radial spoke head protein 4 homolog A
Show all
Predicted intracellular proteins
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001534 [radial spoke]
GO:0003341 [cilium movement]
GO:0003674 [molecular_function]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005856 [cytoskeleton]
GO:0005930 [axoneme]
GO:0031514 [motile cilium]
GO:0035082 [axoneme assembly]
Show all
 600 aa
67.4 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.