Expression of GCNT2 in cancer - Summary - The Human Protein Atlas

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GCNT2

TISSUE

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CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	GCNT2
Gene description	Glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group)
Protein class	Disease related genes Enzymes Plasma proteins Potential drug targets Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Mixed
HPA (cell line):	Cell line enhanced (CACO-2, EFO-21)
HPA (normal tissue):	Tissue enhanced (prostate)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Granular cytoplasmic expression in all tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 1 antibody. HPA026776
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Mixed

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA026776

Cancer	Cancer staining	Protein expression of normal tissue
Breast cancer
Carcinoid
Cervical cancer
Colorectal cancer
Endometrial cancer
Glioma
Head and neck cancer
Liver cancer
Lung cancer
Lymphoma

Cancer	Cancer staining	Protein expression of normal tissue
Melanoma
Ovarian cancer
Pancreatic cancer
Prostate cancer
Renal cancer
Skin cancer
Stomach cancer
Testis cancer
Thyroid cancer
Urothelial cancer

Staining summary	Most malignancies showed moderate to strong cytoplasmic positivity with a granular pattern.

GENE INFORMATION
Gene name	GCNT2 (HGNC Symbol)
Synonyms	bA360O19.2, bA421M1.1, CCAT, GCNT5, IGNT, II, NACGT1, NAGCT1, ULG3
Description	Glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group) (HGNC Symbol)
Entrez gene summary	This gene encodes the enzyme responsible for formation of the blood group I antigen. The i and I antigens are distinguished by linear and branched poly-N-acetyllactosaminoglycans, respectively. The encoded protein is the I-branching enzyme, a beta-1,6-N-acetylglucosaminyltransferase responsible for the conversion of fetal i antigen to adult I antigen in erythrocytes during embryonic development. Mutations in this gene have been associated with adult i blood group phenotype. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
Chromosome	6
Cytoband
Chromosome location (bp)	10492223 - 10629368
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000111846 (version 83.38)
Entrez gene	2651
UniProt	Q06430 (UniProt - Evidence at transcript level), Q8N0V5 (UniProt - Evidence at protein level), Q8NFS9 (UniProt - Evidence at transcript level)
neXtProt	NX_Q06430, NX_Q8N0V5, NX_Q8NFS9
Antibodypedia	GCNT2 antibodies

PROTEIN BROWSER

GCNT2-001	GCNT2-003	GCNT2-004	GCNT2-006	GCNT2-010

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
GCNT2-001 ENSP00000314844 ENST00000316170	Q06430 [Direct mapping] N-acetyllactosaminide beta-1,6-N-acetylglucosaminyl-transferase, isoform B Show all	Enzymes ENZYME proteins Transferases MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014) Show all	GO:0000139 [Golgi membrane] GO:0006024 [glycosaminoglycan biosynthetic process] GO:0006486 [protein glycosylation] GO:0007275 [multicellular organismal development] GO:0008109 [N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity] GO:0008375 [acetylglucosaminyltransferase activity] GO:0016020 [membrane] GO:0016021 [integral component of membrane] Show all	400 aa 45.9 kDa	No	0
GCNT2-003 ENSP00000368917 ENST00000379597	Q8N0V5 [Direct mapping] N-acetyllactosaminide beta-1,6-N-acetylglucosaminyl-transferase, isoform A Show all	Enzymes ENZYME proteins Transferases MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Phobius predicted secreted proteins Predicted intracellular proteins Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014) Show all	GO:0000139 [Golgi membrane] GO:0005575 [cellular_component] GO:0006486 [protein glycosylation] GO:0007179 [transforming growth factor beta receptor signaling pathway] GO:0008109 [N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity] GO:0008284 [positive regulation of cell proliferation] GO:0008375 [acetylglucosaminyltransferase activity] GO:0010608 [posttranscriptional regulation of gene expression] GO:0010718 [positive regulation of epithelial to mesenchymal transition] GO:0010812 [negative regulation of cell-substrate adhesion] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0030335 [positive regulation of cell migration] GO:0034116 [positive regulation of heterotypic cell-cell adhesion] GO:0036438 [maintenance of lens transparency] GO:0051897 [positive regulation of protein kinase B signaling] GO:0070374 [positive regulation of ERK1 and ERK2 cascade] Show all	402 aa 45.9 kDa	No	0
GCNT2-004 ENSP00000265012 ENST00000265012	Q8NFS9 [Direct mapping] N-acetyllactosaminide beta-1,6-N-acetylglucosaminyl-transferase, isoform C Show all	Enzymes ENZYME proteins Transferases MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins TMHMM predicted membrane proteins Phobius predicted secreted proteins Predicted intracellular proteins Plasma proteins Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014) Show all	GO:0000139 [Golgi membrane] GO:0005575 [cellular_component] GO:0006486 [protein glycosylation] GO:0007179 [transforming growth factor beta receptor signaling pathway] GO:0008109 [N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity] GO:0008284 [positive regulation of cell proliferation] GO:0008375 [acetylglucosaminyltransferase activity] GO:0010608 [posttranscriptional regulation of gene expression] GO:0010718 [positive regulation of epithelial to mesenchymal transition] GO:0010812 [negative regulation of cell-substrate adhesion] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0030335 [positive regulation of cell migration] GO:0034116 [positive regulation of heterotypic cell-cell adhesion] GO:0036438 [maintenance of lens transparency] GO:0051897 [positive regulation of protein kinase B signaling] GO:0070374 [positive regulation of ERK1 and ERK2 cascade] Show all	402 aa 46.5 kDa	No	0
GCNT2-006 ENSP00000419411 ENST00000495262	Q8N0V5 [Direct mapping] N-acetyllactosaminide beta-1,6-N-acetylglucosaminyl-transferase, isoform A Show all	Enzymes ENZYME proteins Transferases MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Phobius predicted secreted proteins Predicted intracellular proteins Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014) Show all	GO:0000139 [Golgi membrane] GO:0005575 [cellular_component] GO:0006486 [protein glycosylation] GO:0007179 [transforming growth factor beta receptor signaling pathway] GO:0008109 [N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity] GO:0008284 [positive regulation of cell proliferation] GO:0008375 [acetylglucosaminyltransferase activity] GO:0010608 [posttranscriptional regulation of gene expression] GO:0010718 [positive regulation of epithelial to mesenchymal transition] GO:0010812 [negative regulation of cell-substrate adhesion] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0030335 [positive regulation of cell migration] GO:0034116 [positive regulation of heterotypic cell-cell adhesion] GO:0036438 [maintenance of lens transparency] GO:0051897 [positive regulation of protein kinase B signaling] GO:0070374 [positive regulation of ERK1 and ERK2 cascade] Show all	402 aa 45.9 kDa	No	0
GCNT2-010 ENSP00000386321 ENST00000410107	B7ZBL3 [Direct mapping] N-acetyllactosaminide beta-1,6-N-acetylglucosaminyl-transferase, isoform A Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		116 aa 13.2 kDa	No	0

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