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NEDD9

GENERAL INFORMATION

Gene name

 NEDD9

Gene description

 Neural precursor cell expressed, developmentally down-regulated 9

Protein class

 Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 7
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Cell line enhanced (EFO-21)
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic and nuclear expression in most tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data.

Reliability score

 Uncertain based on 2 antibodies.
HPA038768 , CAB009720
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA038768
CAB009720

GENE INFORMATION

Gene name

 NEDD9 (HGNC Symbol)

Synonyms

 CAS-L, CASS2, HEF1

Description

 Neural precursor cell expressed, developmentally down-regulated 9 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a member of the CRK-associated substrates family. Members of this family are adhesion docking molecules that mediate protein-protein interactions for signal transduction pathways. This protein is a focal adhesion protein that acts as a scaffold to regulate signaling complexes important in cell attachment, migration and invasion as well as apoptosis and the cell cycle. This protein has also been reported to have a role in cancer metastasis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]

Chromosome

 6

Cytoband

 p24.2

Chromosome location (bp)

 11183298 - 11382348

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000111859 (version 83.38)

Entrez gene

 4739

UniProt

 Q14511 (UniProt - Evidence at protein level)

neXtProt

 NX_Q14511

Antibodypedia

 NEDD9 antibodies

PROTEIN BROWSER
NEDD9-001
NEDD9-002
NEDD9-003
NEDD9-007
NEDD9-010
NEDD9-014
NEDD9-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
NEDD9-001
ENSP00000368759
ENST00000379446
Q14511 [Direct mapping]
Enhancer of filamentation 1 Enhancer of filamentation 1 p55
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Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0000922 [spindle pole]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005794 [Golgi apparatus]
GO:0005819 [spindle]
GO:0005925 [focal adhesion]
GO:0005938 [cell cortex]
GO:0007010 [cytoskeleton organization]
GO:0007067 [mitotic nuclear division]
GO:0007155 [cell adhesion]
GO:0007165 [signal transduction]
GO:0007229 [integrin-mediated signaling pathway]
GO:0030027 [lamellipodium]
GO:0040008 [regulation of growth]
GO:0051017 [actin filament bundle assembly]
GO:0051301 [cell division]
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 834 aa
92.9 kDa 		No 0
NEDD9-002
ENSP00000422871
ENST00000504387
Q14511 [Direct mapping]
Enhancer of filamentation 1 Enhancer of filamentation 1 p55
A0A024QZV9 [Target identity:100%; Query identity:100%]
Neural cell expressed, developmentally down-regulated 9, isoform CRA_a
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Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005794 [Golgi apparatus]
GO:0005819 [spindle]
GO:0005925 [focal adhesion]
GO:0005938 [cell cortex]
GO:0007010 [cytoskeleton organization]
GO:0007067 [mitotic nuclear division]
GO:0007155 [cell adhesion]
GO:0007165 [signal transduction]
GO:0007229 [integrin-mediated signaling pathway]
GO:0030027 [lamellipodium]
GO:0040008 [regulation of growth]
GO:0051017 [actin filament bundle assembly]
GO:0051301 [cell division]
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 834 aa
92.9 kDa 		No 0
NEDD9-003
ENSP00000368745
ENST00000379433
Q14511 [Direct mapping]
Enhancer of filamentation 1 Enhancer of filamentation 1 p55
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Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005794 [Golgi apparatus]
GO:0005819 [spindle]
GO:0005925 [focal adhesion]
GO:0005938 [cell cortex]
GO:0007010 [cytoskeleton organization]
GO:0007067 [mitotic nuclear division]
GO:0007155 [cell adhesion]
GO:0007165 [signal transduction]
GO:0007229 [integrin-mediated signaling pathway]
GO:0030027 [lamellipodium]
GO:0040008 [regulation of growth]
GO:0051017 [actin filament bundle assembly]
GO:0051301 [cell division]
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 174 aa
19.3 kDa 		No 0
NEDD9-007
ENSP00000424975
ENST00000508546
D6REP7 [Direct mapping]
Enhancer of filamentation 1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 22 aa
2.5 kDa 		No 0
NEDD9-010
ENSP00000380534
ENST00000397378
D6RBQ2 [Direct mapping]
Enhancer of filamentation 1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005515 [protein binding]
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 32 aa
3.7 kDa 		No 0
NEDD9-014
ENSP00000421282
ENST00000513989
D6RGD7 [Direct mapping]
Enhancer of filamentation 1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005515 [protein binding]
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 29 aa
3.3 kDa 		No 0
NEDD9-201
ENSP00000478563
ENST00000620854
A0A087WUD2 [Direct mapping]
Enhancer of filamentation 1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 685 aa
76.6 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.