Tissue expression of GABRR2 - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	GABRR2
Gene description	Gamma-aminobutyric acid (GABA) A receptor, rho 2
Protein class	FDA approved drug targets Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Not detected
GTEx:	Mixed
FANTOM5:	Tissue enriched (retina)

Protein evidence

Evidence at transcript level

DATA RELIABILITY
Reliability score	Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

Bronchus

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

Skin

N/A

Skin

N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Not detected
GTEx dataset Organ Expression Alphabetical RNA tissue category: Mixed
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Tissue enriched (retina)

GENE INFORMATION
Gene name	GABRR2
Synonyms
Description	Gamma-aminobutyric acid (GABA) A receptor, rho 2 (HGNC Symbol)
Entrez gene summary	GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA receptors, which are ligand-gated chloride channels. The protein encoded by this gene is a member of the rho subunit family and is a component of the GABA receptor complex. [provided by RefSeq, Jul 2008]
Chromosome	6
Cytoband	q15
Chromosome location (bp)	89257208 - 89315299
Protein evidence	Evidence at transcript level (all genes)
Ensembl	ENSG00000111886 (version 83.38)
Entrez gene	2570
UniProt	P28476 (UniProt - Evidence at transcript level)
neXtProt	NX_P28476
Antibodypedia	GABRR2 antibodies

PROTEIN BROWSER

GABRR2-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
GABRR2-001 ENSP00000386029 ENST00000402938	P28476 [Direct mapping] Gamma-aminobutyric acid receptor subunit rho-2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM FDA approved drug targets Small molecule drugs Show all	GO:0004890 [GABA-A receptor activity] GO:0005230 [extracellular ligand-gated ion channel activity] GO:0005254 [chloride channel activity] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006810 [transport] GO:0006811 [ion transport] GO:0007165 [signal transduction] GO:0007214 [gamma-aminobutyric acid signaling pathway] GO:0007268 [synaptic transmission] GO:0007601 [visual perception] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0019904 [protein domain specific binding] GO:0030054 [cell junction] GO:0034220 [ion transmembrane transport] GO:0034707 [chloride channel complex] GO:0042391 [regulation of membrane potential] GO:0043005 [neuron projection] GO:0045202 [synapse] GO:0045211 [postsynaptic membrane] GO:0050877 [neurological system process] GO:0055085 [transmembrane transport] GO:1902476 [chloride transmembrane transport] GO:1902711 [GABA-A receptor complex] Show all	465 aa 54.2 kDa	Yes	4