Expression of HDDC2 in cancer - Summary - The Human Protein Atlas

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HDDC2

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	HDDC2
Gene description	HD domain containing 2
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic and membrane expression in most tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 1 antibody. HPA035677
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA035677

GENE INFORMATION
Gene name	HDDC2 (HGNC Symbol)
Synonyms	C6orf74, CGI-130, dJ167O5.2
Description	HD domain containing 2 (HGNC Symbol)
Entrez gene summary
Chromosome	6
Cytoband	q22.31
Chromosome location (bp)	125219962 - 125302078
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000111906 (version 83.38)
Entrez gene	51020
UniProt	Q7Z4H3 (UniProt - Evidence at protein level)
neXtProt	NX_Q7Z4H3
Antibodypedia	HDDC2 antibodies

PROTEIN BROWSER

HDDC2-002	HDDC2-004	HDDC2-005

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
HDDC2-002 ENSP00000381220 ENST00000398153	Q7Z4H3 [Direct mapping] HD domain-containing protein 2 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005739 [mitochondrion] GO:0070062 [extracellular exosome] Show all	204 aa 23.4 kDa	No	0
HDDC2-004 ENSP00000477277 ENST00000608295	V9GZ04 [Direct mapping] HD domain-containing protein 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		108 aa 12.3 kDa	No	0
HDDC2-005 ENSP00000477042 ENST00000608284	V9GYS5 [Direct mapping] HD domain-containing protein 2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		107 aa 12.3 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.