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HINT3

GENERAL INFORMATION

Gene name

 HINT3

Gene description

 Histidine triad nucleotide binding protein 3

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 General cytoplasmic expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Pending external verification.

Reliability score

 Approved based on 1 antibody.
HPA027914
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable) and breast cancer (unfavourable).
Renal cancer p<0.001
Breast cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA027914

GENE INFORMATION

Gene name

 HINT3 (HGNC Symbol)

Synonyms

 FLJ33126

Description

 Histidine triad nucleotide binding protein 3 (HGNC Symbol)

Entrez gene summary

 Histidine triad proteins, such as HINT3, are nucleotide hydrolases and transferases that act on the alpha-phosphate of ribonucleotides (Brenner, 2002 [PubMed 12119013]).[supplied by OMIM, Mar 2008]

Chromosome

 6

Cytoband

 q22.32

Chromosome location (bp)

 125956781 - 125980244

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000111911 (version 83.38)

Entrez gene

 135114

UniProt

 Q9NQE9 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9NQE9

Antibodypedia

 HINT3 antibodies

PROTEIN BROWSER
HINT3-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
HINT3-001
ENSP00000229633
ENST00000229633
Q9NQE9 [Direct mapping]
Histidine triad nucleotide-binding protein 3
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0000166 [nucleotide binding]
GO:0003824 [catalytic activity]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0008152 [metabolic process]
GO:0016787 [hydrolase activity]
GO:0070062 [extracellular exosome]
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 182 aa
20.4 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.